Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SHSTO
26692
CHIST
8230
HISTO
83853
Histoplasma Antibody, Serum
Clinical Information: Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched
with bird droppings. The usual disease is self-limited, affects the lungs, and is asymptomatic. Chronic
cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially
in young children and in immunosuppressed patients.
Useful For: Aiding in the diagnosis of active histoplasmosis
Interpretation: Complement fixation (CF) titers > or =1:32 indicate active disease. A rising CF titer is
associated with progressive infection. Positive immunodiffusion test results supplement findings of the
CF test. The simultaneous appearance of both H and M precipitin bands indicates active histoplasmosis.
The M precipitin band alone indicates early or chronic disease or a recent histoplasmosis skin test.
Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6
weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a
few weeks to a year, regardless of clinical improvement.
Reference Values:
Mycelial by CF: negative (positives reported as titer)
Yeast by CF: negative (positives reported as titer)
Antibody by immunodiffusion: negative (positives reported as band present)
Clinical References: Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of
Clinical and Laboratory Immunology. Fifth edition. Washington DC, ASP Press, 1997
Histoplasma Antibody, Spinal Fluid
Clinical Information: Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched
with bird droppings. The usual disease is self-limited, affects the lungs, and is asymptomatic. Chronic
cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially
in young children and immunosuppressed patients.
Useful For: Aiding in the diagnosis of Histoplasma meningitis
Interpretation: Any positive serologic result in spinal fluid is significant. Simultaneous appearance of
the H and M precipitin bands indicates active histoplasmosis. The M band alone indicates active or
chronic disease or a recent skin test for histoplasmosis.
Reference Values:
Mycelial by CF: negative (positives reported as titer)
Yeast by CF: negative (positives reported as titer)
Antibody by immunodiffusion: negative (positives reported as band present)
Clinical References: Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of
Clinical and Laboratory Immunology, Washington, DC, ASM Press.1997
Histoplasma capsulatum Antibody Screen, Serum
Clinical Information: Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched
with bird droppings. The usual disease is self-limited, affects the lungs, and is asymptomatic. Chronic
cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially
in young children and in immunosuppressed patients.
Useful For: Evaluating persons with symptoms of respiratory disease, as an aid in the presumptive
laboratory diagnosis of Histoplasma infection
Interpretation: Negative: Indicates antibodies to Histoplasma were not detected. The absence of
antibodies is presumptive evidence that the patient was not infected with Histoplasma. However, the
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