Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FFTRF
57317
FFTLI
57318
TRYPA
32283
Gold JW, Wittner M, et al: Transfusion-associated acute Chagas' disease acquired in the United States.
Ann Intern Med 1989;111:849-851
Trypsin, Fecal
Reference Values:
Greater than or equal to 1:96
A fecal trypsin titer greater than or equal to 1:96 is considered normal.
Fecal trypsin is measured by serially diluting stool in buffer and
identifying the greatest titer at which x-ray film is cleared of its gelatin
emulsion.
Test Performed by: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Trypsin-Like Immunoreactivity
Reference Values:
Reference Range:
10.0-57.0 ng/mL
Expected Cathodic Trypsinogen Concentration Values for the
Varied Disease States:
10.0 - 57.0 ng/mL . . . . . . . . . Healthy Individuals
46.0 ng/mL or less . . . . . . . . Chronic Pancreatitis
92.0 - 850.0 ng/mL . . . . . . . . Acute Pancreatitis
1.4 ng/mL or less . . . . . . . . . Total Pancreatectomy
Results should be correlated with clinical presentation and other
diagnostic data for the diagnosis of pancreatitis.
Test Performed by: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Tryptase, Autopsy
Clinical Information: Tryptase, a neutral protease, is present within the secretory granules of human
mast cells. There are 2 forms of tryptase, designated as alpha and beta, which are encoded by 2 separate
genes. Both are expressed as inactive proenzymes. Alpha-protryptase and beta-protryptase are
spontaneously released from resting mast cells. The levels of the protrypases reflect the total number of
mass cells within the body, but are not an indication of mast cell activation. Beta-protryptase is processed
to a mature form, which is stored in granules and released as an active tetramer that is bound to heparin or
chondroitin sulfate proteoglycans. In contrast, an amino acid change in alpha-protryptase prevents
processing to a mature form. Upon mast cell activation, degranulation releases mature tryptase, which is
almost exclusively in the form of beta-tryptase. After anaphylaxis, mast cell granules release tryptase;
measurable amounts are found in blood, generally within 30 to 60 minutes. The levels decline under
first-order kinetics with a half-life of approximately 2 hours. By comparison, histamine (another
immunologic mediator released by activated mast cells) is cleared from blood within minutes. Increased
serum levels may also occur after allergen challenge or in patients with systemic mastocytosis or mast cell
activation syndrome.
Useful For: Assessing mast cell activation, which may occur as a result of anaphylaxis or allergen
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