Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FFTAP
57299
TARR
82486
immunosuppression while minimizing toxicity Evaluating patient compliance
Interpretation: Most individuals display optimal response to tacrolimus with trough whole blood
levels of 5.0 ng/mL to 15.0 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol,
and comedications. Therapeutic ranges are based on samples drawn at trough (ie, immediately before a
scheduled dose). Blood drawn at other times will yield higher results. The assay is specific for tacrolimus;
it does not cross-react with cyclosporine, cyclosporine metabolites, sirolimus, sirolimus metabolites, or
tacrolimus metabolites. Results by liquid chromatography with detection by tandem mass spectrometry
are approximately 30% less than by immunoassay.
Reference Values:
5.0-15.0 ng/mL
Clinical References: 1. Kahan BD, Keown P, Levy GA, et al: Therapeutic drug monitoring of
immunosuppressant drugs in clinical practice. Clin Ther 2002 March;24(3):330-350 2. Scott LJ, McKeage
K, Keam SJ, et al: Tacrolimus: a further update of its use in the management of organ transplantation.
Drugs 2003;63(12):1247-1297
Tapentadol, Urine
Reference Values:
Not established
Test Performed By: Medtox Laboratories
402 W. County Road D
St. Paul, MN 55112
Tarragon, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
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