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Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

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MTDNS<br />

83131<br />

Useful For: Monitoring of methadone treatment for analgesia or drug rehabilitation Urine<br />

measurement of 2-ethylidene-1,5-dimethyl1-3,3-diphenylpyrrolidine is particularly useful for assessing<br />

compliance with rehabilitation programs.<br />

Interpretation: The absolute concentration of methadone and its metabolites found in patient urine<br />

specimen can be highly variable and do not correlate with dose. However, the medical literature and our<br />

experience show that patients who are known to be compliant with their methadone therapy have ratios of<br />

2-ethylidene-1,5-dimethyl1-3,3-diphenylpyrrolidine (EDDP):methadone of >0.60.(6) An<br />

EDDP:methadone ratio

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