Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FMNM
91829
inhibition of xanthine oxidase (uric acid accumulation). Urine molybdenum concentrations are likely to
be increased above the reference range in patients with metallic joint prosthesis. Prosthetic devices
produced by Zimmer Company and Johnson and Johnson typically are made of aluminum, vanadium,
and titanium. Prosthetic devices produced by Depuy Company, Dow Corning, Howmedica, LCS, PCA,
Osteonics, Richards Company, Tricon, and Whiteside typically are made of chromium, cobalt, and
molybdenum. This List of products is incomplete, and these products change occasionally; see prothesis
product information for each device for composition details.(4-5)
Useful For: Monitoring of parenteral nutrition Monitoring metallic prosthetic implant wear As an
indicator of molybdenum cofactor disease
Interpretation: Molybdenum excretion rates are variable and related to dietary intake. Evaluation of
124 healthy adults by Mayo Clinic suggested a reference range of 6 to 190 mcg/L. The National Health
and Nutrition Examination Survey (NHANES) study reported urine molybdenum ranged from 20 to 180
mcg/L. (Note: NHANES also reported excretion per gram of creatinine as 40-100 mcg/gm creatinine in
adults and 70-240 mcg/gm creatinine in children.) Prosthesis wear is known to result in increased
circulating concentration of metal ions.(5-7) No increase (6-190 mcg/L) in urine molybdenum
concentration is evident with a prosthetic device in good condition. Urine concentrations >200 mcg/L in a
patient with molybdenum-based implant suggest significant prosthesis wear. Increased urine trace element
concentrations in the absence of corroborating clinical information do not independently predict
prosthesis wear or failure. Urine molybdenum 11 years: 40-100 mcg/g creatinine
Reference values have not been established for patients that are 15 years 67-140
Homovanillic acid (HVA)
Newborn 0-73 days 337-1299
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1232