Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

HBIS
209102
Interpretation: A positive, antibodies to hepatitis B core antigen (anti-HBc) total result may
indicate, either, recent, past/resolved, or chronic hepatitis B viral (HBV) infection. Testing for anti-HBc
IgM (HBIM/9015 Hepatitis B Core Antibody, IgM, Serum) is necessary to confirm the presence of
acute or recent hepatitis B. A positive anti-HBc total result with a negative anti-HBc IgM result
indicates past or chronic HBV infection. Differentiation between past/resolved and chronic hepatitis B
can be based on the presence of hepatitis B surface antigen in the latter condition. Negative anti-HBc
total results indicate the absence of recent, past/resolved, or chronic hepatitis B.
Reference Values:
Negative
Interpretation depends on clinical setting.
See Viral Hepatitis Serologic Profiles in Special Instructions.
Clinical References: 1. Badur S, Akgun A: Diagnosis of hepatitis B infections and monitoring of
treatment. J Clin Virol 2001;21(3):229-237 2. Servoss JC, Friedman LS: Serologic and molecular
diagnosis of hepatitis B virus. Clin Liver Dis 2004;8(2):67-281
Hepatitis B Immune Status Profile, Serum
Clinical Information: Hepatitis B virus (HBV) is a DNA virus that is endemic throughout the
world. The infection is spread primarily through percutaneous contact with infected blood products, eg,
blood transfusion, sharing of needles by drug addicts. The virus is also found in virtually every type of
human body fluid and is known to be spread through oral and genital contact. HBV can be transmitted
from mother to child during delivery through contact with blood and vaginal secretions; it is not
commonly transmitted transplacentally. After a course of acute illness, HBV persists in approximately
10% of patients; some of these chronic carriers are asymptomatic.
Useful For: Determining stage of disease, degree of infectivity, prognosis, and immune status of
patients exposed to hepatitis B virus
Interpretation: In a normal course of hepatitis B virus (HBV) infection, hepatitis Be antigen
(HBeAg) along with hepatitis B surface antigen (HBsAg) become detectable in a patient's serum during
the incubation period, before the onset of clinical symptoms. Once clinical symptoms appear, HBeAg
and HBsAg peak and then start to decline. The presence of HBeAg and/or HBsAg indicates active
replication of HBV and positive results indicate patients are highly infectious for hepatitis B. HBV
carriers usually carry HBsAg, and possibly HBeAg, indefinitely in the serum. Hepatitis Be antibody
(anti-HBe) begins to appear after HBeAg has disappeared and may be detectable for several years after
a patient's recovery. Detectable anti-HBe in a patient who is an HBV carrier may indicate inactivity of
the virus and low infectivity of the patient. However, the absence or disappearance of HBeAg or
anti-HBe does not rule out chronic hepatitis B carrier state and/or infectivity. Production of hepatitis B
core antibody (anti-HBc) begins in the window period after HBsAg disappears and before anti-HBs
appears. Anti-HBc is present shortly after the onset of symptoms and can remain present for years after
HBV infection. Anti-HBc IgM is elevated during the acute phase of hepatitis B but will become
negative within 6 months. The presence of hepatitis B surface antibody (anti-HBs) usually indicates
resolution of the HBV infection and acquired immunity to the virus. Anti-HBs may fall below
detectable levels with time. See Viral Hepatitis Serologic Profiles in Special Instructions.
Reference Values:
HEPATITIS Bs ANTIGEN
Negative
HEPATITIS Bc TOTAL ANTIBODY
Negative
HEPATITIS Be ANTIGEN
Negative
HEPATITIS Be ANTIBODY
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