Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

CKMB
82429
CK
8336
CK, TOTAL
Males
6-11 years: 150-499 U/L
12-17 years: 94-499 U/L
> or =18 years: 52-336 U/L
Females
6-7 years: 134-391 U/L
8-14 years: 91-391 U/L
15-17 years: 53-269 U/L
> or =18 years: 38-176 U/L
Reference values have not been established for patients that are less than 6 years of age.
Note: Strenuous exercise or intramuscular injections may cause transient elevation of CK.
CK ISOENZYMES
MM: 100%
MB: 0%
BB: 0%
Clinical References: Apple FS, Quist HE, Doyle PJ, et al: Plasma 99th percentile reference limits
for cardiac troponin and creatine kinase MB mass for use with European Society of
Cardiology/American College of Cardiology consensus recommendations. Clin Chem 2003
Aug;49(8):1331-1336
Creatine Kinase (CK) MB Isoenzyme, Serum
Clinical Information: There are 3 isoenzymes of creatine kinase (CK)-CKBB, CKMM, and
CKMB. The primary source of CKMB is myocardium although it is also found in skeletal muscle.
CKMB levels increase with myocardial damage. Extreme elevations of CKMB can also be associated
with skeletal muscle cell turnover as in polymyositis and to a lesser degree in rhabdomyolysis. It can
also be elevated in cases of carbon monoxide poisoning, crush injuries, pulmonary embolism,
hypothyroidism, and muscular dystrophy.
Useful For: The serial quantitation of serum creatine kinase MB (CKMB) levels, often performed at
admission and 8-hours, 16-hours, and 24-hours after admission, has traditionally been used as an aid in
the diagnosis of myocardial injury. While CKMB has been replaced by troponin assays in the work-up
of many patients with acute chest pain, CKMB may be useful if the initial troponin determination is
abnormal or if a hospitalized patient has a suspected re-infarction.
Interpretation: Creatine kinase MB (CKMB) levels can be detected within 3 to 8 hours of the onset
of chest pain, peak within 12 to 24 hours, and usually return to baseline levels within 24 to 48 hours.
Reference Values:
Males: