Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FDM1
91592
ADNA
8178
FDKYL
DM1 DNA
Reference Values:
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Test Performed by Athena Diagnostics
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DNA Double-Stranded (dsDNA) Antibodies, IgG, Serum
Clinical Information: Double-stranded (ds, native) DNA (dsDNA) antibodies of the IgG class are an
accepted criterion (American College of Rheumatology) for the diagnosis of systemic lupus
erythematosus (SLE).(1-3) dsDNA antibodies are detectable in approximately 85% of patients with
untreated SLE, and are rarely detectable in other connective tissue diseases. Weakly-positive results
caused by low-avidity antibodies to dsDNA are not specific for SLE and can occur in a variety of
diseases. Testing for IgG antibodies to dsDNA is indicated in patients who have a positive test for
antinuclear antibodies (ANA) along with signs and symptoms that are compatible with the diagnosis of
SLE.(2) If the ANA test is negative, there is no reason to test for antibodies to dsDNA.(2) The levels of
IgG antibodies to dsDNA in serum are known to fluctuate with disease activity in lupus erythematosus,
often increasing prior to an increase in inflammation and decreasing in response to therapy.(1,2) See
Connective Tissue Disease Cascade (CTDC) in Special Instructions.
Useful For: Evaluating patients with signs and symptoms consistent with lupus erythematosus (LE)
Monitoring patients with documented LE for flares in disease activity
Interpretation: A positive test result for double-stranded DNA (dsDNA) antibodies is consistent with
the diagnosis of systemic lupus erythematosus. A reference range study conducted at the Mayo Clinic
demonstrated that, within a cohort of healthy adults (n=120), no individuals between the ages of 18 and
60 (n=78) had detectable anti-dsDNA antibodies. Above the age of 60 (n=42), 11.9% of individuals (n=5)
had a borderline result for dsDNA antibodies and 4.8% of individuals (n=2) had a positive result.
Increases of at least 25% in the level of IgG antibodies to dsDNA may indicate an exacerbation of disease.
Reference Values:
or =60 years:
75.0 IU/mL (positive)
Negative is considered normal.
Clinical References: 1. Tran T, Pisetsky D: Detection of anti-DNA antibodies. In Manual of
Molecular and Clinical Laboratory Immunology, 7th edition. Edited by B Detrick, R Hamilton, J Folds.
Washington, DC, ASM Press, 2006, Chapter 115, pp 1027-1032 2. Kavanaugh A, Tomar R, Reveille J, et
al: Guidelines for use of the antinuclear antibody test and tests for specific autoantibodies to nuclear
antigens. Arch Pathol Lab Med 2000;124:71-81 3. Tan EM, Cohen AS, Fries JF, et al: The 1982 revised
criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277
Dock Yellow IgE
91960
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