Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

LLPT
19499
LAD1
81155
Leukemia/Lymphoma Immunophenotyping by Flow Cytometry, Tissue.
Useful For: Evaluating lymphocytoses of undetermined etiology Identifying B- and T-cell
lymphoproliferative disorders involving blood and bone marrow Distinguishing acute lymphoblastic
leukemia (ALL) from acute myeloid leukemia (AML) Immunologic subtyping of ALL Distinguishing
reactive lymphocytes and lymphoid hyperplasia from malignant lymphoma Distinguishing between
malignant lymphoma and acute leukemia Phenotypic subclassification of B- and T-cell chronic
lymphoproliferative disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and
hairy cell leukemia Recognizing AML with minimal morphologic or cytochemical evidence of
differentiation Recognizing monoclonal plasma cells
Interpretation: Report will include a morphologic description, a summary of the procedure, the
percent positivity of selected antigens, and an interpretive conclusion based on the correlation of the
clinical history with the morphologic features and immunophenotypic results.
Reference Values:
An interpretive report will be provided.
This test will be processed as a laboratory consultation. An interpretation of the immunophenotypic
findings and correlation with the morphologic features will be provided by a hematopathologist for
every case.
Clinical References: 1. Hanson CA, Kurtin PJ, Katzman JA, et al: Immunophenotypic analysis of
peripheral blood and bone marrow in the staging of B-cell malignant lymphoma. Blood
1999;94:3889-3896 2. Hanson CA: Acute leukemias and myelodysplastic syndromes. In Clinical
Laboratory Medicine. Edited by KD McClatchey. Baltimore, MD, Williams & Wilkins, Inc, 1994, pp
939-969 3. Morice WG, Leibson PJ, Tefferi A: Natural killer cells and the syndrome of chronic natural
killer cell lymphocytosis. Leuk Lymphoma 2001;41(3-4):277-284 4. Langerak, van Den Beemd,
Wolvers-Tettero, et al: Molecular and flow cytometric analysis of the Vbeta repertoire for clonality
assessment in mature TCR alpha beta T-cell proliferations. Blood 2001;98(1):165-173
Leukemia/Lymphoma Immunophenotyping by Flow
Cytometry, Tissue
Clinical Information: Cellular immunophenotyping, characterizing cells by using antibodies
directed against cell surface markers, is generally regarded as a fundamental element in establishing a
diagnosis of tissue involvement by hematolymphoid malignancies, when used in conjunction with
morphologic assessment. It is also an essential component in subclassification of hematolymphoid
malignancies, when present.
Useful For: Evaluation of tissues for potential involvement by a lymphoproliferative disorder or
acute leukemia
Interpretation: Normal tissues typically contain a mixture of B cells with polytypic surface
immunoglobulin light chain expression and T cells with unremarkable expression of the T
cell-associated antigens CD2, CD3, CD5, and CD7. Typically, no appreciable blast population is
present.
Reference Values:
An interpretive report will be provided.
Clinical References: Morice WG, Hodnefield JM, Kurtin PJ, Hanson CA: An unusual case of
leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant
expression of CD10. Am J Clin Pathol 2004;July;122(1):122-127
Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and
CD11b/CD18 Complex Immunophenotyping, Blood
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