Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

TBNY
82589
may actually represent either a resurgence of an inadequately treated earlier infection or persistent IgG
antibodies from a resolved infection.
Useful For: An aid in the diagnosis of active Treponema pallidum infection Routine prenatal screening
Interpretation: A positive IgG treponemal test suggests infection with Treponema pallidum at some
point in the past, but does not distinguish between treated and untreated infections. This is because
treponemal tests (eg, EIA, multiplex flow immunoassays, or fluorescent treponemal antibody-absorbed
[FTA-ABS]) may remain reactive for life, even following adequate therapy. Therefore, the results of a
nontreponemal assay, such as rapid plasma reagin (RPR), are needed to provide information on a
patientâ€s disease state and history of therapy. Interpretation of results for syphilis IgG and RPR:
-IgG-positive and RPR-positive: Untreated syphilis unless ruled out by treatment history. Patients who
have been treated in the past may be considered to have new syphilis infection if RPR titers show 4-fold,
or greater, increase between acute- and convalescent-phase specimens. -IgG-positive and RPR-negative:
Past, successfully treated syphilis in patients with history of appropriate therapy. In those patients without
a history of treatment, a second treponemal assay (eg, FTA-ABS) should be performed to determine if the
results of the first treponemal-specific assay were truly positive. - Infants