Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

ALDE
84248
GANGLIONIC ACETYLCHOLINE RECEPTOR (ALPHA3) AUTOANTIBODY
< or =0.02 nmol/L
NEURONAL VOLTAGE-GATED POTASSIUM CHANNEL (VGKC) AUTOANTIBODY
< or =0.02 nmol/L
N-TYPE CALCIUM CHANNEL ANTIBODY
< or =0.03 nmol/L
ACETYLCHOLINE RECEPTOR (MUSCLE AChR) BINDING ANTIBODY
< or =0.02 nmol/L
Clinical References: 1. Lennon VA, Sas DF, Busk MF, et al: Enteric neuronal autoantibodies in
pseudo-obstruction with small cell lung carcinoma. Gastroenterology 1991;100:137-142 2. Lucchinetti
CF, Kimmel DW, Lennon VA: Paraneoplastic and oncological profiles of patients seropositive for type
1 anti-neuronal nuclear autoantibodies. Neurology 1998;50:652-657 3. Vernino S, Adamski J, Kryzer
TJ, et al: Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and
cancer-related syndromes. Neurology 1998;50:1806-1813 4. Vernino S, Low PA, Fealey RD, et al:
Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J
Med 2000;343:847-855 5. Pittock SJ, Kryzer TJ, Lennon VA: Paraneoplastic antibodies coexist and
predict cancer, not neurological syndrome. Ann Neurol 2004;56:715-719 6. Dhamija R, Tan KM,
Pittock SJ, et al: Serological profiles aiding the diagnosis of autoimmune gastrointestinal dysmotility.
Clin Gastroenterol Hepatol 2008;6:988-992 7. McKeon A, Lennon VA, Lachance DH, et al: The
ganglionic acetylcholine receptor autoantibody: oncological, neurological and serological
accompaniments. Arch Neurol 66(6):735-741 8. Kraichely RE, Farrugia G, Castell DO, et al: Neural
autoantibody profile of primary achalasia. Dig Dis Sci 2009; June 5 Epub
Autoimmune Liver Disease Evaluation, Serum
Clinical Information: Smooth muscle antibodies (SMA) with specificity for actin are found in
patients with chronic autoimmune hepatitis (CAH) and are often accompanied by the presence of
antinuclear antibodies (ANA). Anti-liver/kidney microsome type 1 antibodies (anti-LKM-1) occur in a
subset of patients with CAH, predominately children. The associated disease is referred to as
autoimmune hepatitis (AIH), type 2. These patients often have other autoantibodies, eg, parietal cell
antibodies and thyroid microsomal antibodies. Anti-mitochondrial antibodies (AMA) is a marker for
primary biliary cirrhosis (PBC), a chronic inflammatory liver disease characterized by the progressive
destruction of interlobular bile ducts with development of cholestasis and eventually cirrhosis.(2)
Useful For: Evaluating patients suspected of having autoimmune congenital adrenal hyperplasia or
primary biliary cirrhosis and evaluation of patients with liver disease of unknown etiology
Interpretation: Positive results for smooth muscle antibodies (SMA) are consistent with the
diagnosis of chronic autoimmune hepatitis. The presence of anti-liver/kidney microsome type 1
antibodies with or without SMA is consistent with autoimmune hepatitis, type 2. The presence of
anti-mitochondrial antibodies is consistent with primary biliary cirrhosis.
Reference Values:
SMOOTH MUSCLE ANTIBODIES
Negative
If positive, results are titered.
Reference values apply to all ages.
LIVER/KIDNEY MICROSOME TYPE 1 ANTIBODIES
< or =20.0 Units (negative)
20.1-24.9 Units (equivocal)
> or =25.0 Units (positive)
Reference values apply to all ages.
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 203