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Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

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19988<br />

PUSE<br />

82362<br />

Pulmonary Cytology with FISH for the Detection of Lung<br />

Cancer on Bronchial Brushing<br />

Clinical Information: The National Cancer Institute estimates that more than 219,000 men and<br />

women in the United States will be diagnosed with cancer of the lung and bronchus in 2009. The dismal<br />

5-year survival of 15% for all patients diagnosed with lung cancer has been attributed to the fact that<br />

more than 80% have advanced disease at the time of diagnosis. Cytologic analysis of brushing<br />

specimens collected during bronchoscopy is widely used to help diagnose malignancy in patients<br />

suspected of having lung cancer. Previous studies have shown that in centrally located tumors, the<br />

diagnostic sensitivity of bronchial brushing cytology ranges from 23% to 93% (mean 61%).(1)<br />

However, the sensitivity is considerably lower in peripheral tumors ranging from 15% to 84% (mean<br />

54%), and even lower in those patients with nodules

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