Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

55 years: 31-409 cells/mcL
Natural Killer (CD16+CD56)
0-2 months: 170-1,100 cells/mcL*
3-5 months: 170-830 cells/mcL*
6-11 months: 160-950 cells/mcL*
12-23 months: 180-920 cells/mcL*
2-5 years: 130-720 cells/mcL*
6-11 years: 100-480 cells/mcL*
12-17 years: 70-480 cells/mcL*
18-55 years: 101-678 cells/mcL
>55 years: 110-657 cells/mcL
Helper Cells (CD4)
0-2 months: 1,600-4,000 cells/mcL*
3-5 months: 1,800-4,000 cells/mcL*
6-11 months: 1,400-4,300 cells/mcL*
12-23 months: 1,300-3,400 cells/mcL*
2-5 years: 700-2,200 cells/mcL*
6-11 years: 650-1,500 cells/mcL*
12-17 years: 530-1,300 cells/mcL*
18-55 years: 424-1,509 cells/mcL
>55 years: 430-1,513 cells/mcL
Suppressor Cells (CD8)
0-2 months: 560-1,700 cells/mcL*
3-5 months: 590-1,600 cells/mcL*
6-11 months: 500-1,700 cells/mcL*
12-23 months: 620-2,000 cells/mcL*
2-5 years: 490-1,300 cells/mcL*
6-11 years: 370-1,100 cells/mcL*
12-17 years: 330-920 cells/mcL*
18-55 years: 169-955 cells/mcL
>55 years: 101-839 cells/mcL
Lymphocyte Ratio
H/S ratio: > or =1.0
*Shearer WT, Rosenblatt HM, Gelman RS, et al: Lymphocyte subsets in healthy children from birth
through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol
2003;112(5):973-980
Clinical References: 1. Betts MR, Casaza JP, Patterson BA, et al: Putative immunodominant human
immunodeficiency virus-specific CD8 T-cell responses cannot be predicted by MHC class I haplotype. J
Virol 2000;74:9144-9151 2. Peters PJ, Borst J, Oorschot V, et al: Cytotoxic T-lymphocyte granules are
secretory lysosomes, containing both perforin and granzymes. J Exp Med 1991;173:1099-1109 3.
Venkataramanan R, Shaw LM, Sarkozi L, et al: Clinical utility of monitoring tacrolimus blood
concentrations in liver transplant patients. J Clin Pharmacol 2001;41:542-551 4. Carmichael KF,
Abayomi A: Analysis of diurnal variation of lymphocyte subsets in healthy subjects and its implication in
HIV monitoring and treatment. 15th Intl Conference on AIDS, Bangkok, Thailand, 2004, Abstract #
B11052 5. Dimitrov S, Benedict C, Heutling D, et al: Cortisol and epinephrine control opposing circadian
rhythms in T-cell subsets. Blood 2009 (prepublished online March 17, 2009) 6. Dimitrov S, Lange T,
Nohroudi K, Born J: Number and function of circulating antigen presenting cells regulated by sleep. Sleep
2007;30:401-411 7. Kronfol Z, Nair M, Zhang Q, et al: Circadian immune measures in healthy
volunteers: relationship to hypothalamic-pituitary-adrenal axis hormones and sympathetic
neurotransmitters. Pyschosomatic Medicine 1997;59:42-50 8. Malone JL, Simms TE, Gray GC, et al:
Sources of variability in repeated T-helper lymphocyte counts from HIV 1-infected patients: total
lymphocyte count fluctuations and diurnal cycle are important. J AIDS 1990;3:144-151 9. Paglieroni TG,
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