Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

CTB
8205
CTBBL
82443
VA: Lambert-Eaton syndrome. In Current Clinical Neurology: Myasthenia Gravis and Related
Disorders. Edited by HJ Kaminski. Totowa, NJ, Humana Press, 2007, (in press) 3. Hoch W, McConville
J, Helms S, et al: Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia
gravis without acetylcholine receptor antibodies. Nat Med 2001 Mar;7(3):365-368
Mycobacterial Culture
Clinical Information: From 1985 to 1992, the number of reported cases of tuberculosis increased
18%. This infectious disease still kills an estimated 3 million persons a year worldwide, making it the
leading infectious disease cause of death.(1) Between 1981 and 1987, AIDS has disseminated
nontuberculous mycobacterial infections; eg,Mycobacteruim intracellulare (MAC). By 1990, the
increased number of disseminated nontuberculous mycobacterial infections resulted in a cumulative
incidence of 7.6%.(2) In addition to the resurgence of Mycobacterium tuberculosis (MTB),
multidrug-resistant MTB (MDR-TB) has become an increasing concern. Laboratory delays in the growth,
identification, and reporting of these MDR-TB cases contributed, at least in part, to the spread of the
disease.(3) The US Centers for Disease Control and Prevention (CDC) have recommended that every
effort must be made for laboratories to use the most rapid methods available for diagnostic mycobacteria
testing. These recommendations include the use of both a liquid and a solid medium for mycobacterial
culture, preferably using an automated system.(3,4)
Useful For: Rapid detection of mycobacteria
Interpretation: A final negative report is issued after 60 days incubation. Positive cultures are reported
as soon as detected.
Reference Values:
Negative
Clinical References: 1. Bloom BR, Murrary CJ: Tuberculosis: commentary on a reemergent killer.
Science 1992;257:1055-1064 2. Horsburgh CR, Jr: Mycobacteruim avium complex infection in the
acquired immunodeficiency syndrome. N Engl J Med 1991;423:1332-1338 3. Tenover FC, Crawford JT,
Huebner RE, et al: The resurgence of tuberculosis: is your laboratory ready? J Clin Microbiol
1993;31:767-770 4. Cohn ML, Waggoner RF, McClatchy JK: The 7H11 medium for the cultivation of
mycobacteria. Am Rev Resp Dis 1968;98:295-296 5. Youmans GP: Cultivation of mycobacteria, the
morphology and metabolism of mycobacteria. In Tuberculosis. Edited by GP Youmans, Philadelphia, WB
Saunders Company, 1979, pp 25-35 6. Kent PT, Kubica GP: Public health mycobacteriology: a guide for
the level III laboratory. USDHHS, Centers for Disease Control, Atlanta, GA, 1985
Mycobacterial Culture, Blood
Clinical Information: Mycobacteremia occurs most often in immunocompromised hosts. The
majority of disseminated mycobacterial infections are due to Mycobacterium avium complex but
bacteremia can also be caused by other mycobacterial species including, but not limited to,
Mycobacterium tuberculosis complex, Mycobacterium kansasii, Mycobacterium fortuitum,
Mycobacterium chelonae, Mycobacterium scrofulaceum, Mycobacterium szulgai, and Mycobacterium
xenopi.(1) Mycobacterial blood cultures may be indicated for patients presenting with signs and
symptoms of sepsis, especially fever of unknown origin.
Useful For: Diagnosing mycobacteremia
Interpretation: A positive result may support the diagnosis of mycobacteremia.
Reference Values:
Negative
If positive, mycobacteria is identified.
A final negative report will be issued after 60 days of incubation.
Clinical References: 1. Pfyffer GE:Mycobacterium:General characteristics, laboratory detection,
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