Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

LPSBF
83690
FLIPR
90347
LPS
8328
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management
by Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New
York, 2007 Chapter 53, Part VI, pp 961-971
Lipase, Body Fluid
Clinical Information: Lipases are enzymes that hydrolyze glycerol esters of long-chain fatty acids
and produce fatty acids and 1-acylglycerol. Bile salts and a cofactor, colipase, are required for full
catalytic activity and greatest specificity. The pancreas is the primary source of serum lipase. Both
lipase and colipase are synthesized in the pancreatic acinar cells and secreted by the pancreas in roughly
equimolar amounts. Serum lipase is filtered and reabsorbed by the kidneys. Pancreatic injury results in
increased serum lipase levels. In pancreatitis, serum lipase becomes elevated at about the same time as
serum amylase (in 4-8 hours). But serum lipase may rise to a greater extent and remain elevated much
longer (7-10 days) than serum amylase. Elevations in serum lipase up to 50 times the upper reference
values have been reported. The increase in serum lipase is not necessarily proportional to the severity of
the attack and normalization is not necessarily a sign of resolution. Both lipase and amylase should be
very elevated in peritoneal fluid arising from the pancreas. Values in fluid of pancreatic origin should be
at least several-fold higher than serum drawn at the same time, even in acute pancreatitis.
Useful For: Investigating pancreatic disorders, usually pancreatitis or pancreatic pseudocysts
Interpretation: Very high values are consistent with pancreatic pseudocysts.
Reference Values:
Not applicable
Lipase, Random Urine
Reference Values:
Adult: 4 U/L or less
Test Performed By: Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
Lipase, Serum
Clinical Information: Lipases are enzymes that hydrolyze glycerol esters of long-chain fatty acids
and produce fatty acids and 2-acylglycerol. Bile salts and a cofactor, colipase, are required for full
catalytic activity and greatest specificity. The pancreas is the primary source of serum lipase. Both
lipase and colipase are synthesized in the pancreatic acinar cells and secreted by the pancreas in roughly
equimolar amounts. Lipase is filtered and reabsorbed by the kidneys. Pancreatic injury results in
increased serum lipase levels.
Useful For: Investigating pancreatic disorders, usually pancreatitis
Interpretation: In pancreatitis, lipase becomes elevated at about the same time as amylase (in 4-8
hours). But lipase may rise to a greater extent and remain elevated much longer (7-10 days) than
amylase. Elevations 2 to 50 times the upper reference have been reported. The increase in serum lipase
is not necessarily proportional to the severity of the attack. Normalization is not necessarily a sign of
resolution. In acute pancreatitis, normoamylasemia may occur in up to 20% of such patients. Likewise,
the existence of hyperlipemia may cause a spurious normoamylasemia. For these reasons, it is suggested
that the 2 assays complement and not exclude each other, and that both enzymes should be assayed.
Reference Values:
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