Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FHBGT
57478
FHBSA
57489
HEAB
80973
Clinical References: 1. Servoss JC, Friedman LS: Serologic and molecular diagnosis of hepatitis B
virus. Clin Liver Dis 2004;8:267-281 2. Valsamakis A: Molecular testing in the diagnosis and
management of chronic hepatitis B. Clin Microb Rev 2007;20(3):426-439 3. Chevaliez S, Bouvier-Alias
M, Laperche S, et al: Performance of version 2.0 of the Cobas AmpliPrep/Cobas TaqMan Real-Time PCR
Assay for Hepatitis B Virus DNA Quantification. J Clin Microbiol 2010;48:3641-3647 4. Vivekanandan
P, Singh MV: Molecular methods in the diagnosis and management of chronic hepatitis B. Expert Rev
Mol Diagn 2010;10(7):921-935
Hepatitis B Virus Genotyping
Reference Values:
Interpretive Information: Hepatitis B Virus Genotype
Both the HBV RT Polymerase and the HBsAg encoding regions are sequenced. Resistance and surface
antigen mutations are reported. In addition, the eight major HBV genotypes (A, B, C, D, E, F, G, and H)
are identified. Mutations in viral sub-populations below 20% of total may not be detected.
This test is performed pursuant to a license agreement with Roche Molecular Systems, Inc.
Test Performed by: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Hepatitis B Virus Surface Antigen, Confirmation
Reference Values:
Reference Range: Non Confirmed
Interpretive Information: Hepatitis B Surface Ag Confirmation
This assay should not be used for blood donor screening, associated re-entry protocols, or for screening
Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/P).
Test Performed by: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Hepatitis Be Antibody, Serum
Clinical Information: During recovery from acute hepatitis B, the hepatitis Be antigen level declines
and becomes undetectable and hepatitis Be antibody (anti-HBe) appears in the serum. Anti-HBe usually
remains detectable for several years after recovery from acute infection. In hepatitis B virus (HBV)
carriers and in patients with chronic hepatitis B, positive anti-HBe results usually indicate inactivity of the
virus and low infectivity of the patients. Positive anti-HBe results in the presence of detectable HBV DNA
in serum indicate active viral replication. See HBV Infection-Diagnostic Approach and Management
Algorithm and Viral Hepatitis Serologic Profile in Special Instructions. Also see The Laboratory
Approach to the Diagnosis and Monitoring of Hepatitis B Infection in Publications.
Useful For: Determining infectivity of hepatitis B virus (HBV) carriers Monitoring infection status of
chronically HBV-infected patients Monitoring serologic response of chronically HBV-infected patients
who are receiving antiviral therapy
Interpretation: Absence of hepatitis Be (HBe) antigen with appearance of HBe antibody is consistent
with loss of hepatitis (HBV) infectivity. Although resolution of chronic HBV infection generally follows
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