Program - Society of Toxicology

Society of Toxicology 2011
Continuing Education (Continued)
Systems Biology
2011 Continuing Education Courses
In the context of toxicology, a systems-level understanding of biology
utilizes “a set of principles and methodologies that links the behavior of
molecules to system characteristics and functions.” Simply put, information
at different levels of organization within an organism is integrated
to obtain an understanding of the organism as a whole and its response to
chemical perturbations. Molecules such as DNA, RNA, and proteins are
organized through a framework of knowledge into signaling pathways
that determine cellular behavior. The cells are organized in the same
manner into tissues, tissues organized into organs, and so on until the
individual functional components that make up an organism are arranged
within multiple, interacting layers. The interrelationships of the individual
components and organizational layers dictate the response of the system
to chemical perturbation. Due to the diversity in the types of data required
for understanding these relationships and the computational tools necessary
for assembling and simulating the flow of information through the
different levels of organization, an interdisciplinary team and collaborative
environment are required. This solicitation is for continuing education
courses taught by interdisciplinary teams with expert knowledge in the
field. A basic-level course would present an overview of systems biology
and demonstrate the types of experimental data, analysis methods, and
simulation approaches that are necessary for success. An advanced level
course would, in addition, extend this knowledge base by addressing
additional technical points like choosing types of data and identifying data
sets for evaluation and choosing computational methods for integration.
Course proposals should contain sufficient examples to demonstrate key
points.
• AM04: Dealing with the Data Deluge: A Live Data Discovery and
Analysis Course (Note: Participants are asked to bring their own
computer with Internet access)
• Poster Session: ‘Omics in Toxicology Research
• AM09: Applications of Computational Systems Biology for
Toxicology
Sunday Morning, March 6
7:00 AM to 7:45 AM
First Level
(See signage at CE Booth for room location)
Biodegradable Materials for Tissue Engineering: Applications
and Safety Assessment
SR01
CE Basic
Chairperson(s): Ronald P. Brown, U.S. FDA, Silver Spring, MD,
and Richard W. Hutchinson, Ethicon Inc., Johnson & Johnson, The
Woodlands, TX.
Sponsor:
Medical Device Specialty Section
Endorsed by:
In Vitro and Alternative Methods Specialty Section
The incorporation of biodegradable materials as a fundamental component
in tissue regeneration strategies began in the early 1980’s and
continues today. The function of a biodegradable material is to act as a
temporary support matrix for transplanted or host cells so as to restore,
maintain, or improve tissue. In order for this function to be achieved,
biodegradable materials must undergo a number of critical examinations
to define their properties. For example, degradation rate, degradation
products, and the tissue response to these products must all be characterized.
In this presentation we will introduce a number of natural and
synthetic biodegradable materials that are commonly considered in regenerative
medicine, as well as some recently developed novel materials. The
techniques utilized to describe their physical properties and the relationship
between physical properties and tissue response will be examined,
and advanced techniques for material characterization and toxicological
effects will be considered. Finally, the application of these biodegradable
materials in tissue engineering strategies will be described.
CE
Stay Competitive
with SOT On-Line Courses
Selected 2009 and 2010 Continuing
Education Courses Available On-Line
Toxicology is an ever-changing field. SOT Continuing
Education courses are an excellent way to enhance your
professional development and learn new techniques. SOT
is dedicated to providing such opportunities and resources
to the scientific community and the Continuing Education
Committee is excited to offer on-line CE courses through
the SOT Web site. Currently there are six on-line courses
from the 48th Annual Meeting in Baltimore, 2009 and the
49th Annual Meeting in Salt Lake City, 2010. Whether you
want a refresher course, or to expand your knowledge, the
on-line Continuing Education courses offer you a convenient
way to stay competitive!
Visit the SOT Web site for more information.
• Biodegradable Materials for Tissue Engineering: Applications and
Safety Assessment, John P. Fisher, University of Maryland, College
Park, MD
Sunday Morning, March 6
8:15 AM to 12:00 NOON
First and Second Level (See signage at CE Booths for room
locations)
Best Practices for Developing, Characterizing, and Applying
Physiologically Based Pharmacokinetic Models in Risk
Assessment
AM02
CE Advanced
Chairperson(s): M.E. (Bette) Meek, University of Ottawa, Ottawa,
Ontario, Canada, and John C. Lipscomb, U.S. EPA, Cincinnati, OH.
Sponsor:
Risk Assessment Specialty Section
Endorsed by:
Biological Modeling Specialty Section
This course is aimed at increasing confidence in the evaluation and application
of PBPK models in quantitative health risk assessments, through
systematic consideration of relevant criteria for their development and
documentation, based on guidance. These principles (Best Practices for
PBPK Modeling Applied to Health Risk Assessment) have been recently
collected and expanded upon in guidance published by the WHO International
Programme on Chemical Safety (2010), and have been the
up-to-date information at www.toxicology.org
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