Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
Wednesday Afternoon, March 9
12:00 NOON to 1:00 PM
Room 201
Meet the Director: Eunice Kennedy Shriver National
Institute of Child Health & Human Development Director
Chairperson(s): Cheryl Lyn Walker, University of Texas M.D.
Anderson Cancer Center, Smithville, TX.
Lecturer: Yvonne Maddox, NICHD, Bethesda, MD.
The mission of the Eunice Kennedy Shriver National Institute of Child
Health & Human Development (NICHD) is to ensure that every person
is born healthy and wanted, that women suffer no harmful effects from
reproductive processes, and that all children have the chance to achieve
their full potential for healthy and productive lives, free from disease or
disability, and to ensure the health, productivity, independence, and wellbeing
of all people through optimal rehabilitation.
Dr. Yvonne Maddox is the deputy director of the NICHD at the National
Institutes of Health (NIH), a position she has held since January 1995.
Dr. Maddox guides the organizations and programs of the NICHD,
advises the director on matters regarding the internal affairs of the institute
budget, and oversees the extramural program that supports research
on child development, developmental biology, nutrition, AIDS, mental
retardation, population issues, reproductive biology, contraception, pregnancy,
and medical rehabilitation. From January 2000, to June 2002, Dr.
Maddox also served as the acting deputy director of the NIH.
Wednesday Afternoon, March 9
12:00 NOON to 1:20 PM
Room 144
Roundtable Session: ‘Omics in Toxic Tort
Chairperson(s): Angela Harris, Center for Toxicology and Environmental
Health, North Little Rock, AR, and Anne Chapelle, Chapelle Toxicology
Consulting, Chadds Ford, PA.
Sponsor:
Ethical, Legal & Social Issues Specialty Section
Endorsed by:
Occupational and Public Health Specialty Section
In the past few years, there has been a growing influx of ‘omics data into the
courtroom. Transcriptomic and proteomic data have already been submitted
in toxic tort litigation as evidence of exposure to a chemical or toxic effect
due to chemical exposure, as have data regarding the genetic polymorphisms
of plaintiffs alleging toxic effects. Submission of ‘omics data will likely
increase exponentially over the next decade, however, there has been little
discussion in the scientific community about how appropriate these data
currently are in proving exposure and effect in any individual or group of
individuals. Issues regarding specificity, interindividual and intraindividual
variation, and validation are addressed in the scientific community as the
data are projected for use in making regulatory decisions, but there is a
serious gap in gauging the sometimes limited datasets submitted as evidence
on which to base causal decisions in a court of law. We will introduces
topics related to ‘omics in toxic tort to open a dialogue among toxicologists
interested in the transition of these data from research tools to causative
tools in litigation.
#2152 12:00 ‘OMICS IN TOXIC TORT. ​A. J. Harris. CTEH,
North Little Rock, AR.
12:00 ENTRY OF ‘OMICS DATA INTO THE
COURTROOM: AN INTRODUCTION. ​Angela
J. Harris
Abstract #
12:05 DO ‘OMICS DATA REQUIRE STRINGENT
VALIDATION AND ARE THE DATA
PREDICTIVE OF TOXICOLOGIC
OUTCOME IN HUMANS? ​Dan Casciano
12:25 POTENTIAL EFFECTS OF GENETIC
PROFILING AND INDIVIDUAL
SUSCEPTIBILITY TO REGULATION
IN THE CHEMICAL AND PETROLEUM
INDUSTRIES. ​Anne Chapelle
12:45 THE USE OF DNA EVIDENCE IN TOXIC
EXPOSURE LITIGATION. ​Anthony G. Hopp
1:05 PANEL DISCUSSION.
Wednesday Afternoon, March 9
12:00 NOON to 1:20 PM
Room 145
Informational Session: Current and Changing Perspectives
on Mycotoxins and Their Potential Health Risks Worldwide
Chairperson(s): Kenneth Voss, U.S. Department of Agriculture, Athens,
GA, and Michael Bolger, U.S. FDA, College Park, MD.
Sponsor:
Food Safety Specialty Section
Endorsed by:
Occupational and Public Health Specialty Section
Regulatory and Safety Evaluation Specialty Section
Risk Assessment Specialty Section
Mycotoxins are ubiquitous contaminants of cereals and other commodities.
Interventions at the agricultural, commodity processing, or food preparation
stages of the field to plate sequence have significantly contributed to
reducing human exposures. However, establishment of tolerable intakes and
regulatory policies limiting the levels of aflatoxins, fumonisins, ochratoxin
A, deoxynivalenol, and other mycotoxins known or suspected to cause
human disease continues as a first line of defense for protecting consumer
health. Contrasting approaches to safety and risk assessment can lead to the
establishment of different tolerable intakes or regulatory standards as, for
example, between the U.S. and the E.U. Improved commodity sampling and
monitoring procedures and additional toxicology data reduce uncertainty in
risk assessment and allow refinement of regulations for mycotoxins, as illustrated
by changes in limits for aflatoxins in tree nuts which have facilitated
international trade without compromising public health. However, regulatory
approaches are not globally consistent and may not effectively protect
public health if enforcement is less stringent. Inconsistent standards can in
some cases lead to exportation of the best quality commodities. Therefore,
implementation of multifaceted bottom up approaches involving better
pre-harvest and post-harvest practices, improved nutrition, and clinical
interventions is also needed to effectively reduce exposures to aflatoxins
and other mycotoxins. Recent research increases our understanding of how
mycotoxins interact with commodity and food matrix constituents, describes
improved biomarkers for exposure assessments, and provides new findings
on the toxicology and mechanisms of action that are essential for both
regulatory and bottom up approaches to reduce mycotoxin exposure and
maintain safe food supplies worldwide.
#2153 12:00 CURRENT AND CHANGING
PERSPECTIVES ON MYCOTOXINS AND
THEIR POTENTIAL HEALTH RISKS
WORLDWIDE. ​K. A. Voss 1 , M. Bolger 2 , S. H.
Henry 2 , J. G. Adams 3 and F. Wu 4 . 1 Toxicology &
Mycotoxin Research Unit, USDA-ARS, Athens,
GA, 2 Center for Food Safety and Applied Nutrition,
U.S. FDA, College Park, MD, 3 Almond Board of
California, Modesto, CA and 4 Environmental and
Occupational Health, University of Pittsburgh,
Pittsburgh, PA.
Wednesday
Poster Sessions
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