Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
SPECIal Events
SOT 2011 Award Recipients (Continued)
Best Postdoctoral Publication Awards
The Postdoctoral Assembly recognizes these three
recipients of their 2011 awards:
Dieldrich S.
Bermudez
Joshua A.
Harrill
Jordan Ned
Smith
Dieldrich S. Bermudez, Ph.D.,
U.S. EPA/NCSU, Raleigh, NC
Bermudez, D.S., Gray, L.E.,
and Wilson, V.S.
Modeling the Interaction of Binary
and Ternary Mixtures of Estradiol
with Bisphenol A and Bisphenol AF
in an In Vitro Estrogen-Mediated
Transcriptional Activation Assay
(T47D-KBluc)
Toxicological Sciences 2010, 116 (2):
477–487
Joshua A. Harrill, Ph.D., U.S. EPA,
Research Triangle Park, NC
Harrill, J.A., Freudenrich, T.M.,
Machacek, D.W., Stice, S.L.,
and Mundy, W.R.
Quantitative Assessment of Neurite
Outgrowth in Human Embryonic
Stem Cell Derived hN2 Cells Using
Automated High-Content Image
Analysis
Neurotoxicology 201, 31(3):277–90
Jordan Ned Smith, Ph.D., Pacific
Northwest National Laboratory,
Richland, WA
Smith, J. N., Wang, J., Lin, Y., and
Timchalk, C.
Pharmacokinetics of the Chlorpyrifos
Metabolite 3,5,6-Trichloro-2-Pyridinol
(TCPy) in Rat Saliva
Toxicological Sciences 2010,
113(12):315–325
Board of Publications Award for the Best
Paper in Toxicological Sciences
The Board of Publications has selected
the paper entitled “Distribution of DNA
Adducts Caused by Inhaled
Formaldehyde Is Consistent with
Induction of Nasal Carcinoma but Not
Leukemia” as the best paper published
in Toxicological Sciences in the past
year (Toxicol. Sci. 2010, 116: 441–451).
The authors of the paper are Kun Lu,
Leonard B. Collins, Hongyu Ru, Edilberto Bermudez, and
James A. Swenberg.
In this paper, the authors used high performance liquid
chromatographic-electrospray ionization-tandem mass
spectrometry methods with selective ion monitoring
(LC-ESI-MS/MS-SRM) to quantify formaldehyde-DNA
adducts in various tissues. Furthermore, by exposing rats
to [ 13 CD 2
]-formaldehyde, they distinguished endogenous
formaldehyde-DNA adducts from those resulting from
inhalation exposure. With this approach, the authors
determined that DNA adducts in the respiratory nasal
epithelium resulting from exogenous exposure to
formaldehyde (10 ppm; 5 days at 6 hr/day) were similar in
abundance to those formed via endogenous formation of
formaldehyde. The relative abundance of the exogenous and
endogenously-formed adducts is notable new information
as no previous research differentiated the precise source
of DNA damage in the nose, and confirmation of DNA
adducts from [ 13 CD 2
]-formaldehyde support a causal role
for genotoxicity in nasal carcinoma. In addition, whereas
adducts from the inhaled stable-labeled formaldehyde were
detected in the nasal epithelium, no adducts attributed to
exogenous exposure to formaldehyde were detected in other
tissues, including bone marrow. These observations offer
important perspective on whether DNA adducts can be
associated with the potential risk of formaldehyde-induced
leukemia.
The paper is being recognized because it provides important
new data that is both timely and salient to enhancing the
mechanistic understanding of the carcinogenic mode
of action of inhaled formaldehyde in respiratory nasal
epithelium. The results are also directly applicable to
improving the scientific basis of human health risk
assessment.
SOT Sponsored Awards
64 SOT 50th Anniversary Annual Meeting