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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #503 Poster Board Number.....................................246 EFFECTS OF AN ASYMMETRY PARAMETER ON CURVE-FITTING FOR SINGLE CHEMICAL AND MIXTURE CONCENTRATION-RESPONSE DATA: 3) MONO-HALOGENATED ACETONITRILES AND ETHYL ACETATES. D. A. Dawson 1 , G. Pöch 2 and T. W. Schultz 3 . 1 Biology/Toxicology, Ashland University, Ashland, OH, 2 Pharmacology and Toxicology, University of Graz, Graz, Austria and 3 Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN. Sponsor: D. Fort. #504 Poster Board Number.....................................247 EFFECTS OF AN ASYMMETRY PARAMETER ON CURVE-FITTING FOR SINGLE CHEMICAL AND MIXTURE CONCENTRATION-RESPONSE DATA: 2) TWENTY RANDOMLY SELECTED SOFT ELECTROPHILE-CONTAINING MIXTURES. N. Genco 1 , H. Bensinger 1 , Z. Il’Giovine 1 , D. A. Dawson 1 , T. W. Schultz 2 and G. Pöch 3 . 1 Biology/ Toxicology, Ashland University, Ashland, OH, 2 Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN and 3 Pharmacology and Toxicology, University of Graz, Graz, Austria. Sponsor: D. Fort. #505 Poster Board Number.....................................248 EFFECTS OF AN ASYMMETRY PARAMETER ON CURVE-FITTING FOR SINGLE CHEMICAL AND MIXTURE CONCENTRATION-RESPONSE DATA: 1) MONO-, DI- AND TRI-HALOGENATED ACETONITRILE COMBINATIONS. D. Guinn 1 , D. A. Dawson 1 , T. W. Schultz 2 and G. Pöch 3 . 1 Biology/Toxicology, Ashland University, Ashland, OH, 2 Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN and 3 Pharmacology and Toxicology, University of Graz, Graz, Austria. Sponsor: D. Fort. Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Animal Models in Toxicological Research Chairperson(s): Lori Moilanen, 3M, St. Paul, MN. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #506 Poster Board Number.....................................301 PROPENTOFYLLINE ATTENUATES METHAMPHETAMINE–INDUCED DOPAMINE RELEASE IN THE RAT CAUDATE-PUTAMEN. Z. Binienda 1 , B. Gough 1 , F. C. Pereira 2 and S. F. Ali 1,2 . 1 Neurotoxicology, U.S. FDA NCTR, Little Rock, AR and 2 Medicine, University of Coimbra, Coimbra, Portugal. #507 Poster Board Number.....................................302 A DOSE VOLUME TOLERABILITY STUDY TO EVALUATE WHETHER CD-1 MICE ARE EXTRAORDINARILY SENSITIVE TO LIPID- BASED DRUG DELIVERY VEHICLES: CAPMUL PG-12, CAPMUL MCM, AND CREMOPHOR EL. R. Yeager 1 , B. Padden 2 , J. Lipari 2 , J. Maher 3 , K. Desino 4 , P. Katavolos 5 , D. Weddle 5 and K. Sachdeva 1 . 1 Toxicology, Abbott, Abbott Park, IL, 2 Pharmaceutics, Abbott, Abbott Park, IL, 3 Investigative Toxicology and Pathology, Abbott, Abbott Park, IL, 4 Drug Metabolism, Abbott, Abbott Park, IL and 5 Pathology, Abbott, Abbott Park, IL. #508 Poster Board Number.....................................303 ESTABLISHMENT OF 2-STEP ULTRA- SHORT-TERM CARCINOGENICITY TEST IN CB6F1 TG RASH2 MICE - STUDY ON SEVERAL PROMOTERS-. K. Urano 1 , M. Kawabe 2 , M. Suguro 2 , T. Numano 2 , M. Yasuda 1 , H. Tsutsumi 1 and F. Furukawa 2 . 1 Central Institute for Experimental Animals, Kawasaki, Japan and 2 DIMS Institute of Medical Science, Inc., Ichinomiya, Japan. #509 Poster Board Number.....................................304 THE EFFECT OF CLOZAPINE TREATMENT ON NEUTROPHIL KINETICS IN SPRAGUE- DAWLEY RATS. A. Lobach and J. Uetrecht. Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada. #510 Poster Board Number.....................................305 TROGLITAZONE-INDUCED LIVER INJURY IN CHIMERIC MICE WITH HUMANIZED LIVER. M. Kakuni 1 , M. Morita 2 , Y. Katoh 1 , M. Nakajima 2 , C. Tateno 1 and T. Yokoi 2 . 1 Study Service Department, PhoenixBio Co., Ltd., Higashi- Hiroshima, Japan and 2 Division of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan. #511 Poster Board Number.....................................306 CHARACTERIZATION OF IRON OVERLOAD IN RATS AS A POTENTIAL MODEL OF HUMAN HEMOCHROMATOSIS. S. J. Wildt 1 , T. Bartnikas 2 , M. D. Fleming 2 and D. M. Cooper 1 . 1 Laboratory Animal Medicine, Harlan Laboratories, Indianapolis, IN and 2 Department of Pathology, Children’s Hospital Boston, Boston, MA. Sponsor: A. Jackson. #512 Poster Board Number.....................................307 PAIN ASSESSMENT IN MONOSODIUM IODOACETATE (MIA)-INDUCED OSTEOARTHRITIS (OA) MODEL. R. Samadfam, L. Chouinard and S. Y. Smith. Toxicology, Charles River Preclinical Services, Montréal, QC, Canada. Sponsor: M. Vézina. #513 Poster Board Number.....................................308 PROTEOMIC ANALYSIS OF MAINSTREAM CIGARETTE SMOKE-EXPOSED FISHER RAT NOSES IN A SHORT-TERM STUDY. C. A. Carter and M. Misra. Life Sciences, Lorillard Tobacco Company, Greensboro, NC. 160 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #514 Poster Board Number.....................................309 FIRST IN MONKEY (FIM) PERFORMED TRACKING OF MAGNETIC CAPSULE INSIDE THE GASTROINTESTINAL TRACT WITH 3D-MAGMA. H. Richert 2 , S. H. Korte 1 and S. Abert 2 . 1 Covance Laboratories GmbH, Muenster, Germany and 2 Matesy GmbH, Jena, Germany. Sponsor: G. Weinbauer. #515 Poster Board Number.....................................310 TOXIC EFFECTS OF ETHYL TERTIARY BUTYL ETHER EXPOSURE IN CYP2E1 KNOCKOUT MICE. R. Wang 1 , Y. Yanagiba 1 , K. Ohtani 1 , M. Suda 1 , Z. Weng 1 and T. Nakajima 2 . 1 Japan National Institute of Occupational Safety and Health, Kawasaki, Japan and 2 Nagoya University School of Medicine, Nagoya, Japan. Sponsor: N. Mei. #516 Poster Board Number.....................................311 THE INDIVIDUAL AND INTERACTIVE EFFECTS OF LIPOPOLYSACCHARIDE AND DEOXYNIVALENOL ON FREE FATTY ACIDS IN THE LIVER AND BRAIN OF RATS. I. Ross 1 , T. Boyle 1 , W. D. Johnson 1 , L. H. Garthoff 1 , S. M. Ahn 1 , M. W. O’Donnell 2 and C. S. Kim 1 . 1 U.S. FDA, Laurel, MD and 2 Biostatistics Branch, Laurel, MD. Sponsor: H. Luu. #517 Poster Board Number.....................................312 FEASIBILITY OF APPLYING DRIED BLOOD SPOT (DBS) SAMPLING IN EXPLORATORY TOXICITY STUDIES IN THE RAT. W. Scott 1 , R. Hunter 2 , Z. Shen 2 , J. May 1 , L. Liu 1 , S. Vekich 2 , W. Huang 1 , R. Rahavendran 2 and A. Sacaan 1 . 1 Drug Safety Research and Development, Pfizer Inc., San Diego, CA and 2 Pharmacokinetics Dynamics and Metabolism, Pfizer Inc., San Diego, CA. #518 Poster Board Number.....................................313 APPLICATION OF PREDICTION INTERVAL BASED MIXED-EFFECT MODELS TO EVALUATE MONKEY BODY WEIGHT CHANGE IN PRECLINICAL TOXICOLOGY STUDIES. D. Zhao 1 , R. Yeager 1 , Y. Lan 2 , C. Lin 2 and M. Duvall 1 . 1 Toxicology, Abbott, Abbott Park, IL and 2 Statistics, Abbott, Abbott Park, IL. #519 Poster Board Number.....................................314 LONGITUDINAL COMPARISON OF SPONTANEOUS OCULAR LESIONS IN THE NORMAL RAT AND MOUSE ON CHRONIC TOXICOLOGY STUDIES. K. Tenneson, N. Cicciu and M. Vézina. Toxicology, Charles River Preclinical Services, Montréal, QC, Canada. #520 Poster Board Number.....................................315 COMPARISON OF ANESTHETIC EFFECTS ON ELECTRORETINOGRAMS (ERG) IN DOGS. G. Glazier, D. Martel, T. Halle, S. Duval, T. Bryant and M. Vézina. Toxicology, Charles River Preclinical Services, Montréal, QC, Canada. #521 Poster Board Number.....................................316 APPLICATION OF THE rasH2 MOUSE IN CARCINOGENESIS AND BIOMARKER STUDIES. Y. Shimamura 1 , R. Arai1, A. Sunohara 1 , F. Baba1, K. Urano 2 , H. Tsutsumi 2 , M. Ito 2 , A. Hirayama 1 , M. Sugimoto 1 , T. Soga 1 , T. Nomura 2 and M. Tomita 1 . 1 Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan and 2 Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan. Abstract # #522 Poster Board Number.....................................317 DEVELOPMENT OF INDUCIBLE IN VIVO RNAi MOUSE MODELS FOR TARGET VALIDATION. J. Hitchcock 1 , V. Beuger 2 , H. Kissel 2 , N. Pullen 1 and A. Rossi 1 . 1 Pfizer Ltd., Sandwich, Kent, United Kingdom and 2 TaconicArtemis GmbH, Cologne, Germany. Sponsor: M. Sharpe. #523 Poster Board Number.....................................318 METABOLOMIC ASSESSMENT OF TEMPORAL CHANGES INDUCED DURING THE COURSE OF A TYPICAL OVERNIGHT FAST IN THE SD RAT. D. G. Robertson, S. Stryker and J. Vassallo. Discovery Toxicology, Bristol-Myers Squibb Company, Princeton, NJ. #524 Poster Board Number.....................................319 BACKGROUND OCULAR CHANGES FOLLOWING TRANSVITREAL SUBRETINAL DOSING IN THE RHESUS AND CYNOMOLGUS MONKEY. A. Préfontaine, M. Bussières and M. Vézina. Toxicology, Charles River Preclinical Services, Montréal, QC, Canada. #525 Poster Board Number.....................................320 DOSE RESPONSE OF DIURON-INDUCED URINARY BLADDER HYPERPLASIA IN MALE WISTAR RATS. A. F. Cardoso, S. M. Ihlaseh, M. S. da Rocha, M. G. Nascimento, J. V. de Camargo and M. C. de Oliveira. Pathology, Sao Paulo State University - UNESP - Medical School, Botucatu, Brazil. #526 Poster Board Number.....................................321 BIOAVAILABILITY AND DISTRIBUTION OF SOIL BOUND POLYCYCLIC AROMATIC HYDROCARBONS IN SWINE. R. E. Peters 1 , S. D. Siciliano 1,2 and M. Wickstrom 2 . 1 Soil Science, University of Saskatchewan, Saskatoon, SK, Canada and 2 Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada. Sponsor: L. Weber. #527 Poster Board Number.....................................322 CENTELLA ASIATICA AN EMERGING ALTERNATIVE TO ALZHEIMER’S DISEASE. M. Ahuja, M. Dhanasekaran, M. A. Buabeid, V. Suppiramaniam and E. A. AbdelRahman. Harrison School of Pharmacy, Auburn, AL. #528 Poster Board Number.....................................323 CHARACTERIZATION OF LYMPHOCYTE SUBSETS IN PERIPHERAL BLOOD OF HEALTHY, OBESE, AND TUMOR-BEARING DOGS. M. Ko 1 , Q. Peng 1 , A. Gonzales 2 , E. McCandless 2 , M. Aleo 2 , R. McCall 2 , S. Kamerling 2 , Q. Zong 1 , D. Sace 1 , R. Yafawi 1 , J. Wang 1 and A. John-Baptiste 1 . 1 Drug Safety, Research & Developement, Pfizer, San Diego, CA and 2 Animal Health, Pfizer, Kalamazoo, MI. Sponsor: W. Huang. #529 Poster Board Number.....................................324 INVESTIGATION, OPTIMIZATION, AND VALIDATION OF MINIPIG IMMUNOPHENOTYPING BY FLOW CYTOMETRY. A. Shen and S. Sokolowski. Drug Safety R&D, Pfizer, Inc., Groton, CT. Sponsor: J. Colangelo. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 161
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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