Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#900 10:35 ONCOGENIC MICRORNAS AS DRUG
TARGETS FOR CANCER CHEMOTHERAPY. ​
S. Safe. Veterinary Physiology, Texas A&M
University, College Station, TX.
#901 11:05 MICRORNA REGULATION OF DEP-
INDUCED INFLAMMATION IN AIRWAY
EPITHELIAL CELLS. ​M. J. Jardim, L. Dailey
and D. Diaz-Sanchez. U.S. EPA, Chapel Hill, NC.
Sponsor: T. Tal.
11:35 PANEL DISCUSSION/Q&A. ​Mark Hahn
Tuesday Morning, March 8
9:00 AM to 11:45 AM
Room 207
Workshop Session: Identification of Chemical Respiratory
Allergens: Principles and New Developments
Chairperson(s): Ian Kimber, University of Manchester, Manchester,
United Kingdom, and Takahiko Yoshida, Asahikawa Medical College,
Asahikawa, Japan.
Sponsor:
Immunotoxicology Specialty Section
Japanese Society of Immunotoxicology
There are several new developments and opportunities in chemical respiratory
allergy. This is an important occupational health problem associated
with significant morbidity, and occasionally mortality. The identification
and characterization of chemical respiratory allergens has presented toxicologists
with some significant challenges, not least because there remains
uncertainty about the immunological mechanisms that may result in allergic
sensitization of the respiratory tract. Moreover, there is continuing debate
about the relevant routes of exposure for the acquisition of sensitization.
Previously attention focused primarily on the development of predictive
test methods based upon animal, mainly guinea pig and mouse models, or
through exploitation of (quantitative) structure-activity relationships. More
recently, however, other strategies have been proposed and developed,
included among which are modified peptide reactivity assays, and the
identification of altered gene expression signatures specific for chemical
respiratory allergens. Recent progress will be reviewed critically and prospects
for the development of widely accepted methods for the identification
and characterization of chemical respiratory allergens will be discussed.
#902 9:00 IDENTIFICATION OF CHEMICAL
RESPIRATORY ALLERGENS: PRINCIPLES
AND NEW DEVELOPMENTS. ​I. Kimber 1 and
T. Yoshida 2 . 1 Faculty of Life Sceinces, University of
Manchester, Manchester, UK, United Kingdom and
2
Asahikawa Medical College, Asahikawa, Japan.
9:00 INTRODUCTION. ​Ian Kimber
#903 9:05 IDENTIFICATION AND
CHARACTERIZATION OF CHEMICAL
RESPIRATORY ALLERGENS:CHALLENGES
AND OPPORTUNITIES. ​I. Kimber. Faculty of
Life Sceinces, University of Manchester, Manchester,
UK, United Kingdom.
#904 9:37 ANIMAL MODELS OF CHEMICAL
RESPIRATORY ALLERGY. ​J. Pauluhn.
Toxicology, Bayer HealthCare, Wuppertal, Germany.
#905 10:09 PEPTIDE REACTIVITY OF CHEMICAL
RESPIRATORY ALLERGENS. ​J. F. Lalko 1,2 .
1
The University of Manchester, Manchester, United
Kingdom and 2 Research Institute for Fragrance
Materials Inc., Woodcliff Lake, NJ. Sponsor: I.
Kimber.
Abstract #
#906 10:41 GENE EXPRESSION CHANGES AND
THE IDENTIFICATION OF CHEMICAL
RESPIRATORY ALLERGENS. ​D. R. Boverhof.
The Dow Chemical Company, Midland, MI.
#907 11:13 A MODIFIED LOCAL LYMPH NODE ASSAY
FOR HAZARD IDENTIFICATION OF
CHEMICAL RESPIRATORY ALLERGENS. ​
T. Yoshida. Health Science, Asahikawa Medical
University, Asahikawa, Hokkaido, Japan.
Tuesday Morning, March 8
9:00 AM to 11:45 AM
Room 144
Emerging Global Public Health Issues
Workshop Session: Safer Products for a Sustainable World:
Linking Chemical Design and Toxicology
Chairperson(s): Patricia Beattie, SciVera, Inc. and Arcalis Scientific,
LLC, West Bloomfield, MI, and Hal Zenick, U.S. EPA, Research Triangle
Park, NC.
Sponsor:
Risk Assessment Specialty Section
Endorsed by:
Disease Prevention Task Force
Occupational and Public Health Specialty Section
There is no more greatly studied characteristic of molecules than their
ability to exhibit biological activity and major industries, including pharmaceuticals
and pesticides, are based on this science. Billions of dollars
are spent to evaluate the risk of chemicals in the environment and billions
more are to discover new chemicals that have beneficial biological effects.
One of the goals of green chemistry first introduced by Paul Anastas and
John Warner in 1998, is to reduce or eliminate the use and generation of
hazardous substances throughout the design, manufacture, and use of chemical
products. The principles of green chemistry and engineering are now
being widely embraced beyond the traditional chemical and pharmaceutical
industries, into formulators and manufacturers of consumer products. Information
on the potential hazards of the substances that are incorporated into
final products is needed in order to assess and design safer products and
processes. Recent advances in understanding the mechanisms of toxicity,
the development of in vitro high-throughput screening (HTS) assays as well
as other predictive and in silico methods allow for rapid assessment and
screening of many more chemicals than had been possible in the past using
traditional whole animal models. With the reform of the Toxic Substances
Control Act (TSCA) and other state and global regulations requiring toxicity
information and assessment of safer alternatives on thousands of chemicals,
it is imperative that these predictive toxicology methods be incorporated
into the assessment paradigm. As new industrial chemicals are designed
with green chemistry and engineering principles, these toxicology screening
methods can be used to efficiently evaluate substances, minimizing potential
adverse health effects both in the workplace and to the final consumer.
#908 9:00 SAFER PRODUCTS FOR A SUSTAINABLE
WORLD: LINKING CHEMICAL DESIGN
AND TOXICOLOGY. ​H. Zenick 1 and P. Beattie 2 .
1
National Health Environmental Effects Research
Lab., U.S. EPA, Research Triangle Park, NC and
2
SciVera, Inc. and Arcalis Scientific, LLC, West
Bloomfield, MI.
9:00 INTRODUCTION. ​Patricia Beattie
#909 9:05 GREEN CHEMISTRY DONE RIGHT: A
PARTNERSHIP BETWEEN CHEMICAL
DESIGN AND TOXICOLOGY. ​P. Anastas.
Office of Research and Development, U.S. EPA,
Washington, D.C. Sponsor: H. Zenick.
Tuesday
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