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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # Wednesday Morning, March 9 9:00 AM to 12:30 PM Exhibit Hall Poster Session: Phase I and II Biotransformation Enzymes Chairperson(s): Bhagavatula Moorthy, Baylor College of Medicine, Houston, TX. Displayed: 9:00 AM–12:30 PM Author Attended: 11:00 AM–12:30 PM #1837 Poster Board Number.....................................121 HUMAN DIOXIN-INDUCIBLE CYTOCHROME P450, CYP2S1, METABOLIZES CYCLOOXYGENASE— AND LIPOXYGENASE—DERIVED EICOSANOIDS. P. H. Bui 1,2,3 , S. Imaizumi 4 , S. Beedanagari 1,2 , S. T. Reddy 4 and O. Hankinson 1,2,3 . 1 Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, 2 Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, 3 Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA and 4 Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA. #1838 Poster Board Number.....................................122 CYTOCHROME P450’S VARY IN THEIR ABILITY TO GENERATE REACTIVE OXYGEN SPECIES. V. Mishin 1 , D. E. Heck 2 , D. L. Laskin 1 and J. D. Laskin 3 . 1 Pharmacology & Toxicology, Rutgers University, Piscataway, NJ, 2 Environmental Health Sciences, New York Medical College, Valhalla, NY and 3 Environmental & Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. #1839 Poster Board Number.....................................123 BACKGROUND LEVELS OF THE TRYPTOPHAN PHOTOPRODUCT 6-FORMYLINDOLO[3, 2-b]CARBAZOLE (FICZ) DETERMINE THE OUTCOME OF IN VITRO BIOASSAYS FOR AH-RECEPTOR ACTIVATION. U. Rannug 1 , E. Wincent 1,2 , A. Mohammadi Bardbori 2 , T. Alsberg 3 and A. Rannug2. 1 Department of Genetics, Microbiology, and Toxicology, Stockholm University, Stockholm, Sweden, 2 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 3 Department of Applied Environmental Science, Stockholm University, Stockholm, Sweden. #1840 Poster Board Number.....................................124 CYTOCHROME P450 CYP2AA, CYP3A, AND PREGNANE X RECEPTOR IN ZEBRAFISH (DANIO RERIO): EXPRESSION IN RESPONSE TO POTENTIAL AGONISTS FOR PXR. A. Kubota 1 , A. Bainy 2,1 , M. Siebert 2 , B. Woodin 1 , J. Goldstone 1 and J. Stegeman 1 . 1 Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA and 2 Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil. #1841 Poster Board Number.....................................125 TRANSCRIPTIONAL AND POST- TRANSCRIPTIONAL REGULATIONS OF CYP1A1 GENE BY LEAD IN HUMAN HEPATOMA HEPG2 CELL. H. M. Korashy 1 and A. O. El-Kadi 2 . 1 Pharmacology & Toxicology, King Saud University, Riyadh, Saudi Arabia and 2 Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. #1842 Poster Board Number.....................................126 EFFECTS OF THE STANDARDIZED EXTRACT OF CENTELLA ASIATICA (ECA 233) ON HUMAN CYTOCHROME P450. S. T. Lawanprasert, N. Niwattisaiwong, W. Warisnoicharoen, P. Seeka, T. Winitthana and M. H. Tantisira. Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Sponsor: L. Robertson. #1843 Poster Board Number.....................................127 BUTADIENE EPOXIDE METABOLITES INHIBIT CYP2E1 ACTIVITY. J. H. Hartman 1 , G. P. Miller 1 and G. Boysen 2 . 1 Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR and 2 Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR. #1844 Poster Board Number.....................................128 EFFECTS OF HERBAL EXTRACTS ON CYTOCHROME P450-ASSOCIATED MONOOXYGENASE ACTIVITIES IN ENRICHED RAT LIVER MICROSOMES. D. Lee, M. Kong, G. Ko, S. Yoo, H. Ha, T. Jeong and M. Kang. Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea. #1845 Poster Board Number.....................................129 IS THE PROMISCUITY OF THE ARYL HYDROCARBON RECEPTOR A MYTH? E. Wincent 1,2 , J. Bengtsson 2 , U. Rannug 2 and A. Rannug 1 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 2 Department of Genetics, Microbiology, and Toxicology, Stockholm University, Stockholm, Sweden. #1846 Poster Board Number.....................................130 IN VITRO METABOLISM OF DI(2- ETHYLHEXYL) PHTHALATE (DEHP) BY VARIOUS HUMAN AND RAT ORGAN MICROSOMES, S9, AND CYP ISOFORMS. J. Campbell, K. Choi, H. Joo, R. Clewell and H. Clewell. The Hamner Institutes, Research Triangle Park, NC. #1847 Poster Board Number.....................................131 USE OF ALTERNATIVE PROMOTERS AS REGULATORS OF HUMAN MICROSOMAL EPOXIDE HYDROLASE EXPRESSION. H. Nguyen, X. Yang and C. J. Omiecinski. Center for Molecular Toxicology, Penn State University, University Park, PA. #1848 Poster Board Number.....................................132 RESPECTIVE ROLES OF CYP2A5 AND CYP2F2 IN THE BIOACTIVATION OF 3-METHYLINDOLE IN MOUSE OLFACTORY MUCOSA AND LUNG. X. Zhou 1 , J. D’Agostino 1 , L. Li 1 , G. S. Yost 2 and X. Ding 1 . 1 Wadsworth Center, Albany, NY and 2 University of Utah, Salt Lake City, UT. 280 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1849 Poster Board Number.....................................133 MICROSOMAL METABOLISM OF NAPHTHALENE (NA) IN TARGET AND NON-TARGET RODENT TISSUES: COMPARISON WITH NON-HUMAN PRIMATES. A. Buckpitt, D. Morin, P. Edwards and L. Van Winkle. Veterinary Medicine, University of California Davis, Davis, CA. #1850 Poster Board Number.....................................134 CYTOCHROME P450S MEDIATE THE METABOLISM AND ARE REGULATED BY BERBERINE IN MICE AND HUMANS. Y. J. Guo 1 , F. Li 2 , Y. Chen 1 , Z. Tan 1 , C. Pope 3 , X. Chen 2 , X. Ma 2 , C. D. Klaassen 2 and H. Zhou 1 . 1 Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, China, 2 University of Kansas Medical Center, Kansas and 3 XenoTech, LLC, Kansas City, KS. #1851 Poster Board Number.....................................135 CYTOCHROME P450 2S1 MEDIATED REGULATION OF HUMAN LUNG CELL PROLIFERATION. A. M. Rowland, T. W. Madanayake, T. P. Fidler and L. Montoya. Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM. #1852 Poster Board Number.....................................136 NEW ROLES OF CYTOCHROME P4501A1 (CYP1A1) AND THE ENDOGEONUS ARYL HYDROCARBON RECEPTOR (AHR) LIGAND 6-FORMYLINDOLO[3, 2-b] CARBAZOLE (FICZ) IN REGULATION OF CELL GROWTH. A. Rannug 1 , H. Mei 1 , A. Mohammmadi-Bardbori 1 , Y. Wei 2 and U. Rannug 3 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2 Department of Community Medicine, Mercer University School of Medicine, Macon, GA and 3 Department of Genetics, Microbiology, and Toxicology, Stockholm University, Stockholm, Sweden. #1853 Poster Board Number.....................................137 TRANSCRIPTOMIC EVALUATION OF CANINE SUSPENSION-SHIPPED AND PRE- PLATED HEPATOCYTES: COMPARISON TO LIVER. A. Ditewig, M. Liguori, E. Blomme and Y. Yang. Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories, Abbott Park, IL. #1854 Poster Board Number.....................................138 RAT CYTOCHROME P450 2S1 (CYP2S1) IS NOT INDUCED BY THE ARYL HYDROCARBON RECEPTOR (AHR) AGONIST PCB126. B. Wang 1 , L. Robertson 1,2 , K. Wang 3 and G. Ludewig 1,2 . 1 Human Toxicology, University of Iowa, Iowa City, IA, 2 Occupational & Environmental Health, University of Iowa, Iowa City, IA and 3 Biostatistics, University of Iowa, Iowa City, IA. #1855 Poster Board Number.....................................139 REGULATION OF CARBONYL REDUCTASE EXPRESSION AND ACTIVITY BY AH RECEPTOR LIGANDS. E. A. Amouzougan 1 , C. R. Klocke 1 , H. A. Charlier 2 and K. A. Mitchell 1 . 1 Biological Sciences, Boise State University, Boise, ID and 2 Chemistry and Biochemistry, Boise State University, Boise, ID. Abstract # #1856 Poster Board Number.....................................140 INCREASED LEVELS OF OXIDATIVE DNA ADDUCTS IN CYTOCHROME P450 (CYP)1A2-NULL MICE AND PREMATURE INFANTS EXPOSED TO HYPEROXIA: NOVEL BIOMARKERS FOR BRONCHOPULMONARY DYSPLASIA (BPD). B. Moorthy 1 , L. Wang 1 , C. Xanthi 1 , G. Zhou 2 and W. Jiang 1 . 1 Pediatrics, Baylor College of Medicine, Houston, TX and 2 Institute of Biotechnology, Texas A&M University, Houston, TX. #1857 Poster Board Number.....................................141 ALTERATION IN EXPRESSION OF MOUSE CARBOXYLESTERASE ISOFORMS FOLLOWING DEVELOPMENTAL DELTAMETHRIN EXPOSURE: ROLE OF NUCLEAR RECEPTORS. A. A. Baker and J. R. Richardson. Toxicology, UMDNJ-Rutgers University, Piscataway, NJ. #1858 Poster Board Number.....................................142 TRANSCRIPTIONAL REGULATION OF THE HUMAN MICROSOMAL EPOXIDE HYDROLASE GENE (EPHX1) DRIVEN BY A FAR UPSTREAM ALTERNATIVE PROMOTER. S. Su 1,2 and C. Omiecinski 2 . 1 Huck Institute of Life Sciences, Penn State University, University Park, PA and 2 Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA. #1859 Poster Board Number.....................................143 ROS PRODUCTION AND ENZYME INACTIVATION OF ZEBRAFISH CYP1S BY HALOGENATED AROMATIC HYDROCARBONS. J. V. Goldstone 1 , P. Urban 2 , D. Pompon 2 and J. J. Stegeman 1 . 1 Biology, Woods Hole Oceanographic Institution, Woods Hole, MA and 2 CNRS-Gif sur Yvette, Gif sur Yvette, France. #1860 Poster Board Number.....................................144 OXIDATIVE METABOLISM OF STYRENE IN CYP2F2-NULL MOUSE LIVER AND LUNG MICROSOMES. S. Shen 1 , L. Li 2 , X. Ding 2 and J. Zheng 1,3 . 1 Center for Developmental Therapeutics, Seattle Children’s Research Institute, Seattle, WA, 2 Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, NY and 3 Department of Pediatrics, University of Washington, Seattle, WA. #1861 Poster Board Number.....................................145 DOWN REGULATION OF MOUSE CYP2DS IN PRIMARY HEPATOCYTES USING RNAI. O. Elraghy 1 , B. Damiri 2 and W. S. Baldwin 1,2 . 1 Biological Sciences, Clemson University, Clemson, SC and 2 Environmental Toxicology Program, Clemson University, Clemson, SC. #1862 Poster Board Number.....................................146 DIFFERENTIAL SULFOTRANSFERASE EXPRESSION AFTER FASTING AND CALORIC RESTRICTION IN LIVERS OF LEAN (C57BL/6) AND OBESE (OB/OB) MICE. N. H. Knudsen 1 , S. R. Kulkarni 2 , J. Xu 2 , R. S. King 2 and A. L. Slitt 2 . 1 Biochemistry, Moravian College, Bethlehem, PA and 2 Biomedical and Pharmaceutical Sciences, University of Rhode Island, Bethlehem, RI. Wednesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 281
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Society of Toxicology 2011 ToxExpo
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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