Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#1760 2:33 OPTIMIZATION OF HIGH-THROUGHPUT
NANOMATERIAL DEVELOPMENTAL
TOXICITY TESTING IN ZEBRAFISH
EMBRYOS. ​A. Wang 1 , C. Matson 2 , S. Frady 1 , M.
Arnold 2 , S. Padilla 3 , R. T. Di Giulio 2 and K. Houck 1 .
1
National Center for Computational Toxicology, U.S.
EPA, Research Triangle Park, NC, 2 Center for the
Environmental Implications of NanoTechnology,
Duke University, Durham, NC and 3 ISTD, NHEERL,
U.S. EPA, Research Triangle Park, NC.
#1761 2:54 TOXICITY OF INTRANASALLY-
ADMINISTERED SILVER NANOPARTICLES. ​
M. Genter 1 , N. C. Newman 1 , H. G. Shertzer 1 , S. F.
Ali 2 , S. M. Hussain 3 and B. Bolon 4 . 1 Environmental
Health, University of Cincinnati, Cincinnati,
OH, 2 Neurochemistry Laboratory, Division of
Neurotoxicology, NCTR/U.S. FDA, Jefferson,
AR, 3 Applied Biotechnology Branch, AFRL,
Wright-Patterson AFB, Dayton, OH and 4 GEMpath,
Longmont, CO.
#1762 3:15 RECOVERY FROM SILVER
NANOPARTICLE EXPOSURE-INDUCED
LUNG FUNCTION CHANGES IN SPRAGUE-
DAWLEY RATS. ​I. Yu 1 , J. Sung 2 , J. Ji 3 , K. Song 2 ,
J. Lee 1 , J. Lee 4 , J. Park 5 , H. Park 6 , C. Kang 1 and
K. Ahn 7 . 1 Hoseo University, Asan, Republic of
Korea, 2 Korea Conformity Laboratories, Incheon,
Republic of Korea, 3 Samung Electronics, Ltd.,
Suwon, Republic of Korea, 4 Occupational Lung
Diseases Institute, COMWEL, Ansan, Republic of
Korea, 5 Chung-Ang University, Seoul, Republic of
Korea, 6 Korea Research Institute of Standards and
Science, Daejeon, Republic of Korea and 7 Hanyang
University, Seoul, Republic of Korea.
#1763 3:35 CLEARANCE OF ACCUMULATED
SILVER AFTER CESSATION OF SILVER
NANOPARTICLE (AGNP) EXPOSURE IN
TISSUES OF SPRAGUE-DAWLEY RATS. ​
J. Lee 1 , I. Yu 1 , Y. Kim 2 , K. Song 3 , H. Ryu 3 , J.
Sung 3 , M. Kwon 1 , J. Park 4 , J. Lee 5 , H. Park 6 , C.
Kang 1 and D. Marshak 7 . 1 Hoseo University, Asan,
Republic of Korea, 2 KT&G, Daejeon, Republic of
Korea, 3 Korea Conformity Laboratories, Incheon,
Republic of Korea, 4 Chung-Ang University, Seoul,
Republic of Korea, 5 Occupational Lung Diseases
Institute, COMWEL, Ansan, Republic of Korea,
6
Korea Research Institute of Standards and Science,
Daejeon, Republic of Korea and 7 PerkinElmer,
Boston, MA.
#1764 3:55 PREMATURE CELLULAR SENESCENCE-
INDUCED BY NANOPARTICLE EXPOSURE:
A NOVEL APPROACH TO NANOTOXICITY
TESTING. ​D. Ellis and S. Hussain. Air Force
Research Laboratory 711 HPW/RHPBA, Wright-
Patterson AFB, OH.
Tuesday Afternoon, March 8
2:15 PM to 3:15 PM
Room 140B
Exhibitor Hosted Session: Automated GLP Infusion Studies:
Improved Process Quality and Labor Utilization
Presented by: Instech Solomon
GLP infusion studies, rife with high labor content and opportunities for
quality improvement, present a classic automation opportunity. This session
describes the costs (investment) and benefits (reduced labor and improved
process data quality) of moving from manual to Part 11 compatible automated
processes.
Abstract #
Tuesday Afternoon, March 8
2:15 PM to 3:15 PM
Room 140A
Exhibitor Hosted Session: Machine Learning and Exposure
to Modeling in the Prediction of In Vivo Toxicity from High
Content Screening (HCS) Data
Presented by: Cyprotex Discovery
High content screening (HCS) is a powerful tool for generating insight into
changes arising from exposure of cells to potentially toxic xenobiotics.
Linking these changes to in vivo toxic responses enables the creation of
predictive models for in vivo drug-mediated toxicity. In this presentation,
novel developments in modeling of drug-induced hepatotoxicity from HCS
data will be described.
Tuesday Afternoon, March 8
2:15 PM to 3:15 PM
Room 156
Exhibitor Hosted Session: Predictive Analysis of Cell
Viability, Apoptosis and ADME/Tox Properties Using
Multiparametric In Vitro Assays and Human Induced
Pluripotent Stem (iPS) Cell-Derived Cardiomyocytes and
Hepatocytes
Presented by: Promega Corporation
This seminar will highlight the use of multiplexed bioluminescent and fluorescent
cell-based assays with human iPS cell-derived cardiomyocytes and
hepatocytes that offer a powerful new approach to predictive analysis of cell
viability, apoptosis and ADME/Tox properties while enabling streamlined
data collection, high data quality and robust interpretation with biologically
relevant human cell model systems.
Tuesday Afternoon, March 8
3:00 PM to 4:15 PM
CC Room 103
Undergraduate Faculty Meeting
Chairperson(s): Aaron Barchawsky, University of Pittsburgh,
Pittsburgh, PA.
Sponsor:
Education Committee
The Education Committee and the Undergraduate Education Subcommittee
are hosting the Undergraduate Toxicology Faculty Meeting for all
faculty involved in the teaching of toxicology to undergraduates, or for
those interested in including toxicology at the undergraduate level. Hear
an update on initiatives for undergraduate faculty, provide your input, and
network.
Tuesday Afternoon, March 8
3:30 PM to 4:30 PM
Room 140B
Exhibitor Hosted Session: Cryopreserved HepaRG: An
Alternative In Vitro Screening Tool for Human Hepatic Drug
Metabolism, and Safety Applications
Presented by: Life Technologies
The use of primary human hepatoxytes in screening applications is limited
by tissue availability, donor variability, cost and a relative short lifespan in
culture. The use of HepaRG cells solves these limitations without sacrificing
many of the critical hepatocyte traits such as drug metabolizing enzyme
expression, functional transport proteins, and expression of key nuclear
receptor pathways.
Tuesday
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