Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # Monday Morning, March 7 9:15 AM to 12:00 NOON Room 204 Platform Session: Use of Embryonic Stem Cells in Toxicology Chairperson(s): Blake Anson, Cellular Dynamics International, Madison, WI, and Patrick McNutt, USAMRICD, Aberdeen Proving Ground, MD. #71 9:15 COMPARISON OF THE EMBRYONIC STEM CELL TEST, THE WHOLE EMBRYO CULTURE AND THE ZEBRAFISH EMBRYO TEST AS ALTERNATIVE METHODS FOR DEVELOPMENTAL TOXICITY TESTING OF TRIAZOLES. E. de Jong 1,2 , M. Barenys 3 , S. Hermsen 2,4 , A. Verhoef 2 and A. H. Piersma 1,2 . 1 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands, 2 National Institute for Public Health and the Environment, Bilthoven, Netherlands, 3 Toxicology Unit, Public Health Department, School of Pharmacy, University of Barcelona, Barcelona, Spain and 4 Department of Health Risk Analysis and Toxicology, NUTRIM, University of Maastricht, Maastricht, Netherlands. Sponsor: H. van Loveren. #72 9:34 PREDICTING DEVELOPMENTAL TOXICITY OF TOXCAST PHASE I CHEMICALS USING HUMAN EMBRYONIC STEM CELLS AND METABOLOMICS. N. C. Kleinstreuer 2 , P. R. West 1 , A. M. Weir-Hauptman 1 , A. M. Smith 1 , T. B. Knudsen 2 , E. L. Donley 1 and G. G. Cezar 1,3 . 1 Stemina Biomarker Discovery, Inc., Madison, WI, 2 ORD/NCCT, U.S. EPA, Durham, NC and 3 University of Wisconsin Madison, Madison, WI. #73 9:53 TESTING OF PRO-TERATOGENS IN THE EMBRYONIC STEM CELL TEST: SIMULATION OF METABOLIC CONVERSION BY TREATMENT WITH DEFINED MIXTURES OF PARENT COMPOUNDS AND THEIR RESPECTIVE METABOLITES. A. E. Seiler, J. Kaltenhaeuser, U. Gruber and A. Luch. ZEBET, Federal Institute for Risk Assessment, Berlin, Germany. Sponsor: R. Chapin. #74 10:12 COREXIT EC9527A INHIBITS RETINOL SIGNALING IN P19 MOUSE PLURIPOTENT CELLS. Y. Chen and D. H. Reese. DMB, OARSA, CFSAN, U.S. FDA, Laurel, MD. Sponsor: S. Sahu. #75 10:30 TERATOGENICITY OF VALPROIC ACID DERIVATIVES: EVALUATION OF STRUCTURE-ACTIVITY RELATIONSHIPS USING THE EMBRYONIC STEM CELL TEST. C. Riebeling 1 , A. E. Seiler 1 , K. Becker 2 , R. Buesen 1,6 , D. Eickel 5 , J. Kaltenhaeuser 1 , F. Meyer 3 , H. Nau 4 , R. Pirow 1 , B. Slawik 1 , A. Visan 1 , J. Volland 3 , H. Spielmann 1 and A. Luch 1 . 1 ZEBET, Federal Institute for Risk Assessment, Berlin, Germany, 2 Nonclinical Drug Safety, Bayer Schering Pharmacology AG, Berlin, Germany, 3 Nycomed GmbH, Barsbüttel, Germany, 4 Department of Food Toxicology and Chemical Analysis, University of Veterinary Medicine Hannover, Hannover, Germany, 5 Product Application Laboratory, Advion BioSystems, Ithaca, NJ and 6 Mechanistic Toxicology, BASF, Ludwigshafen, Germany. Sponsor: R. Chapin. #76 10:48 The roles of MKK4 and MKK7 in developmental toxicity. J. Wang 1,2 , L. Chen 1 , L. Zhang 2 and Y. Xia 1 . 1 Environmental Health, University of Cincinnati, Cincinnati, OH and 2 Histology & Embryology, Southern Medical University, Guangzhou, China. #77 11:06 DEVELOPMENT OF EMBRYONIC STEM CELL-DERIVED NEURONS FOR BOTULINUM NEUROTOXIN RESEARCH AND DRUG DISCOVERY. P. McNutt and M. Mesngon. USAMRICD, Gunpowder, MD. Sponsor: G. Rockwood. #78 11:24 TCDD INDUCED MODIFICATION OF TRANSCRIPTION FACTOR SIGNALING AND CARTILAGE DYSMORPHOGENESIS IN VIVO. W. Dong 1,2 and S. W. Kullman 1 . 1 Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC and 2 College of Animal Science and Technology, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, China. #79 11:42 METHYL MERCURY INDUCED PERTURBATION OF NEURAL DIFFERENTIATION OF MURINE EMBRYONIC STEM CELLS OVER TIME DESCRIBED BY TRANSCRIPTOMICS. P. T. Theunissen 1,2 , J. L. Pennings 1 , J. C. Kleinjans 2 , J. F. Robinson 1 and A. H. Piersma 1,3 . 1 Laboratory for Health Protection Research, National Institute of Public Health and the Environment (RIVM), Bilthoven, Netherlands, 2 Department of Health Risk Analysis and Toxicology, University of Maastricht, Maastricht, Netherlands and 3 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands. Monday Morning, March 7 9:15 AM to 10:15 AM Room 156 Exhibitor Hosted Session: Logistic and Technical Challenges of Conducting Developmental Toxicity Studies in Nonhuman Primates Presented by: MPI Research The preclinical safety testing of biotherapeutics poses a particular challenge in selecting a relevant animal species for use in toxicology studies. The nonhuman primates are most frequently used for developmental and reproductive toxicity testing when commonly used rodents and/or rabbits are not pharmacologically relevant species. In this presentation, the logistical and technical challenges when conducting developmental toxicity testing in nonhuman primates will be presented and discussed. Monday Morning, March 7 9:15 AM to 10:15 AM Room 140A Exhibitor Hosted Session: Phototoxicology: Current Practices and Regulatory Status Presented by: Charles River Phototoxic risk can be assessed during drug development from candidate screening through Phase IV. When and how to evaluate for phototoxic potential is not always clear and the changing regulatory status adds additional uncertainty. The tools for phototoxicity testing and how current/ upcoming regulations may affect these approaches will be presented. 122 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # Monday Morning, March 7 9:30 AM to 10:30 AM Room 304 (Ticket Required; Postdoctoral Scholars only, limited seating) Conversation with Dr. Collins Chairperson(s): Michelle La Merrill, Mount Sinai School of Medicine, New York, NY. Sponsor: Postdoctoral Assembly Dr. Collins will meet informally for discussion with postdoctoral scholars after his Plenary Lecture. Monday Morning, March 7 9:30 AM to 10:50 AM Room 304 Undergraduate Education Program: Poster Session for Visiting Students Chairperson(s): Julio Davila, Chesterfield, MD. Sponsors: Education Committee K–12 Task Force This event is for undergraduate students and advisors receiving 2011 SOT travel funding and SOT program volunteers assisting with the Undergraduate Program. Full program details are found pages 85–86. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall Poster Session: Hypersensitivity: Methods and Mechanisms Chairperson(s): Victor Johnson, NIOSH, Morgantown, WV. Displayed: 9:30 AM–12:30 PM Author Attended: 9:30 AM–11:00 AM #80 Poster Board Number.....................................101 VALIDATION OF THE CANDIDA ALBICANS DELAYED-TYPE HYPERSENSITIVITY (DTH) MODEL IN THE B6C3F1 MOUSE FOLLOWING EXPOSURE TO AZATHIOPRINE (AZA), CYCLOPHOSPHAMIDE (CPS), CYCLOSPORIN A (CSA), DEXAMETHASONE (DEX), OR BENZO[E] PYRENE (B[E]P) FOR 28 DAYS. M. J. Smith, C. E. McLoughlin, W. Auttachoat and K. L. White. Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA. #81 Poster Board Number.....................................102 A RETROSPECTIVE OF THE REGULATORY USE OF THE LOCAL LYMPH NODE ASSAY FOR THE NOTIFICATION OF NEW CHEMICALS IN EUROPE. S. Casati, A. Angers- Loustau and L. Tosti. European Commission (Joint Research Centre), Ispra, Italy. Sponsor: D. Basketter. Abstract # #82 Poster Board Number.....................................103 COMPARISON OF 3H-THYMIDINE INCORPORATION AND NON- RADIOACTIVE CELL COUNTEND AS ENDPOINTS OF THE LOCAL LYMPH NODE ASSAY (LLNA) IN ROUTINE TESTING. S. N. Kolle, A. O. Gamer, A. Schrage, N. Honarvar, V. Strauss, R. Landsiedel and B. van Ravenzwaay. Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany. Sponsor: A. Van Cott. #83 Poster Board Number.....................................104 VEHICLE-DEPENDENT EFFECTS ON HEXYLCINNAMALDEHYDE RESPONSES IN THE LLNA. G. L. DeGeorge, M. Carathers, J. Tao and D. R. Cerven. MB Research Laboratories, Spinnerstown, PA. #84 Poster Board Number.....................................105 RESPIRATORY TRACT RESPONSES IN WISTAR AND BN RATS, SENSITIZED AND CHALLENGED BY INHALATION WITH THE CONTACT ALLERGEN DINITROCHLOROBENZENE (DNCB). J. van Triel 1 , J. Arts 1,2 and F. Kuper 1 . 1 Toxicology and Applied Pharmacology, TNO, Zeist, Netherlands and 2 Technology & Engineering, Akzo Nobel, Arnhem, Netherlands. Sponsor: R. Woutersen. #85 Poster Board Number.....................................106 STEPS TOWARDS THE DEVELOPMENT OF AN INTEGRATED APPROACH FOR THE PREDICTION OF SKIN SENSITIZATION POTENTIAL USING DATA FROM SEVERAL ALTERNATIVE TEST SYSTEMS. C. Ryan 1 , J. Jaworska 2 , P. Kern 2 , J. Chaney 1 and F. Gerberick 1 . 1 Procter & Gamble Company, Cincinnati, OH and 2 Procter & Gamble Company, Brussels, Belgium. #86 Poster Board Number.....................................107 DIFFERENTIATION OF PROHAPTENS FROM DIRECT ACTING CONTACT CHEMICAL ALLERGENS USING A CYTOCHROME P450 REDUCTASE DEFICIENT MOUSE MODEL. I. Chipinda, F. M. Blachere, S. E. Anderson and P. D. Siegel. HELD, CDC/NIOSH, Morgantown, WV. #87 Poster Board Number.....................................108 PLASMACYTOID DENDRITIC CELL-BASED ASSAY AS AN IN VITRO ALTERNATIVE FOR CHEMICAL ALLERGENICITY SCREENING. M. Spratt, M. Klausner, S. Ayehunie and M. Child. MatTek Corp, Ashland, MA. Sponsor: P. J. #88 Poster Board Number.....................................109 CELL LINE-BASED PREDICTION OF SENSITIZATION BY COUPLING KERATINOCYTE METABOLISM AND DENDRITIC CELL ACTIVATION. J. Hennen 1 , P. Aeby 2 , C. Goebel 3 , T. Schettgen 4 , A. Oberli 5 , M. Kalmes 1 and B. Blömeke 1 . 1 Environmental Toxicology, University Trier, Trier, Germany, 2 Consultant, Marly, Switzerland, 3 Procter & Gamble Co., Darmstadt, Germany, 4 RWTH Aachen University, Aachen, Germany and 5 Federal Office of Public Health (FOPH), Bern, Switzerland. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 123
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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