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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Abstract # Abstract # #2638 Poster Board Number.....................................249 SULFORAPHANE INDUCES GLUTATHIONE-S-TRANSFERASE ACTIVITY AND DECREASES AFLATOXIN B1-DNA ADDUCTS IN SPRAGUE-DAWLEY RATS. J. L. Fiala 1,2 , N. Wiriyachan 3,4 , P. A. Egner 5 , J. D. Groopman 5 , R. G. Croy 1,2 , P. Navasumrit 3 , M. Ruchirawat 3,4 and J. M. Essigmann 3,4 . 1 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2 Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 3 Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok, Thailand, 4 Faculty of Science, Mahidol University, Bangkok, Thailand and 5 Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. #2639 Poster Board Number.....................................250 DOSE RESPONSE CHARACTERIZATION OF DIETARY PHENOBARBITAL-INDUCED GENE EXPRESSION, ENZYME INDUCTION, AND CELL PROLIFERATION IN THE LIVERS OF MALE AND FEMALE MICE. B. Gollapudi 1 , H. Kan 1 , A. Wood 1 , J. Murray 1 , S. Hester 2 , A. Goetz 3 , R. Currie 4 and D. Geter 1 . 1 The Dow Chemical Company, Midland, MI, 2 U.S. EPA, Research Triangle Park, NC, 3 Syngenta Crop Protection, Inc., Greensboro, NC and 4 Syngenta Ltd., Bracknell, Berkshire, United Kingdom. #2640 Poster Board Number.....................................251 OXIDATIVE DNA DAMAGE AND DNA BINDING INDUCED BY 2, 2-BIS (BROMOMETHYL)-1, 3-PROANEDIOL IN HUMAN BLADDER CELLS: POSSIBLE DUAL MECHANISMS IMPLICATED IN ITS CARCINOGENICITY. W. Kong, R. K. Kuester, A. Gallegos and I. Sipes. Pharmacology, University of Arizona, Tucson, AZ. #2641 Poster Board Number.....................................252 TRICHLOROETHYLENE- AND TETRACHLOROETHYLENE-INDUCED RENAL CARCINOGENESIS: INSIGHTS FROM HUMAN, ANIMAL BIOASSAY, AND MECHANISTIC STUDIES. M. R. Gwinn, K. Z. Guyton, J. Jinot, C. S. Scott, K. A. Hogan and W. A. Chiu. U.S. EPA, Washington, D.C. #2642 Poster Board Number.....................................253 COMPARISON OF AFLATOXIN-DNA ADDUCT LEVELS IN MALE AND FEMALE INFANT B6C3F1 MICE. L. L. Woo 1 , P. A. Egner 2 , C. Belanger 1 , R. Wattanawaraporn 1 , L. Trudel 1 , G. N. Wogan 1,3 , J. D. Groopman 2 , R. G. Croy 1,3 and J. M. Essigmann 1,3 . 1 Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 2 Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD and 3 Chemistry, Massachusetts Institute of Technology, Cambridge, MA. #2643 Poster Board Number.....................................254 NO LUNG TOXICITY FROM STYRENE IN CYP2F2 KNOCKOUT MICE. G. Cruzan 1 , J. S. Bus 2 , X. Ding 3 , J. A. Hotchkiss 2 , J. R. Harkema 4 and R. Gingell 5 . 1 ToxWorks, Bridgeton, NJ, 2 Toxicology and Environmental Research and Consulting, Dow Chemical Company, Midland, MI, 3 New York State Department of Health, Wadsworth Center for Labs. and Research, State University of New York at Albany, Albany, NY, 4 Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI and 5 Environmental and Product Health, Shell Oil Company, Houston, TX. #2644 Poster Board Number.....................................255 COVALENT BINDING OF 14 C 2-METHOXY-4-NITROANILINE IN MALE SPRAGUE-DAWLEY RATS. R. Snyder 1 , S. Waidyanatha 2 , I. Surh 2 , T. Banks 1 , P. Patel 1 , S. Black 1 and T. Fennell 1 . 1 RTI International, Research Triangle Park, NC and 2 National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC. #2645 Poster Board Number.....................................256 DIFFERENTIAL MODULATION OF CANCER-RELATED MOLECULAR NETWORKS IN HUMAN AND RAT URINARY BLADDER CELLS EXPOSED TO TRIVALENT ARSENICALS. K. Bailey 1 , K. Wallace 2 , S. Thai 2 , D. C. Wolf 2 , S. W. Edwards 2 and R. C. Fry 1 . 1 Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC and 2 U.S. EPA, Research Triangle Park, NC. #2646 Poster Board Number.....................................257 THE EFFECTS OF ORAL TREATMENT WITH TRANSFLUTHRIN ON THE BLADDER EPITHELIUM OF RATS AND MICE AND ITS METABOLITE, TETRAFLUOROBENZOIC ACID ON UROTHELIAL CELLS IN VITRO. S. M. Cohen 1 , L. Arnold 1 , S. Lautraite 2 , L. Sheets 2 , S. Wason 2 , B. Stahl 2 , D. Eigenberg 3 , K. L. Pennington 1 , S. Kakiuchi-Kiyota 1 and M. Yokohira 1 . 1 University of Nebraska Medical Center, Omaha, NE, 2 Bayer AG, Bayer CropScience, Monheim, Germany and 3 Xenometrics, Stilwell, KS. #2647 Poster Board Number.....................................258 NEUROBEHAVIORAL ALTERATIONS IN CARG-BOX BINDING FACTOR-A KNOCK- OUT MICE. J. T. Barrett 1,2 , J. R. Richardson 2 , X. Zhang 3 , M. Fang 2 , K. R. Reuhl 2,4 and H. Zarbl 2 . 1 GSBS, UMDNJ, Piscataway, NJ, 2 EOHSI, RWJMS, UMDNJ, Piscataway, NJ, 3 University of Washington, Seattle, WA and 4 Rutgers, Piscataway, NJ. #2648 Poster Board Number.....................................259 INFLUENCE OF BENZO(A)PYRENE (BAP) BIOTRANSFORMATION ON BAP-INDUCED CYTOTOXICITY IN HT-29 HUMAN COLON CANCER CELLS. J. N. Myers and A. Ramesh. Biochemistry & Cancer Biology, Meharry Medical College, Nashville, TN. Thursday 352 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #2649 Poster Board Number.....................................260 EFFECTS OF SUBCHRONIC SODIUM ARSENITE ON MALIGNANT TRANSFORMATION MARKERS IN MCF-7 CELLS. A. D. Rios-Perez 1 , R. Ruiz-Ramos 1 , L. T. Lopez-Carrillo 2 and M. E. Cebrian 1 . 1 Toxicology, CINVESTAV, Mexico City, DF, Mexico and 2 CISP, INSP, Cuernavaca, Morelos, Mexico. #2650 Poster Board Number.....................................261 DOES HELICOBACTER PYLORI PARTICIPATE IN T HELPER-1 MEDIATED IMMUNE ACTIVATION IN COLORECTAL CANCER PATIENTS? B. A. Engin 1 , A. Karakaya 1 and A. Engin 2 . 1 Department of Toxicology, Gazi University, Faculty of Pharmacy, Ankara, Turkey and 2 Department of General Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey. #2651 Poster Board Number.....................................262 TOXICOGENOMIC PROFILING OF FORMALDEHYDE-EXPOSED NORMAL AND TRANSFORMED HUMAN ORAL KERATINOCYTES. R. Ceder 1 , M. Merne 1 , J. Nilsson 1 , C. Staab 2 , J. Höög 2 , C. M. Thompson 3 and R. C. Grafström 1,4 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 3 ToxStrategies, Inc., Katy, TX and 4 Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland. #2652 Poster Board Number.....................................263 A GENOME-WIDE CELL SIGNALING RNA- INTERFERENCE SCREEN TO IDENTIFY NOVEL REGULATORS OF THE DNA DAMAGE RESPONSE. B. van de Water 1 , J. Carreras 1 , L. von Stechow 1 , R. Sidappa 1 , A. Pines 2 , J. Olsen 3 , H. Vrieling 2 , L. Mullenders 2 and E. Danen 1 . 1 Division of Toxicology, Leiden University, Leiden, Netherlands, 2 Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands and 3 Panum Institute, University of Copenhagen, Copenhagen, Denmark. #2653 Poster Board Number.....................................264 GLUCOSE ENHANCES MENADIONE MEDIATED HYDROGEN PEROXIDE FORMATION IN BETA CELLS. M. A. Palo 1 , T. L. Womack 1 , E. Heart 2 and J. P. Gray 1,2 . 1 Science Chemistry, United States Coast Guard Academy, New London, CT and 2 Biocurrents Research Center, Marine Biological Laboratory, Woods Hole, MA. #2654 Poster Board Number.....................................265 THE DURATION OF THE EVALUATION PERIOD OF THE POSITIVE CONTROL GROUP FOR RASH2 SHORT-TERM CARCINOGRNICITY STUDIES. S. A. Shah, M. A. Paranjpe and E. A. Zahalka. Mammalian Toxicology, BioReliance Corporation, Rockville, MD. #2655 Poster Board Number.....................................266 CYTOTOXICITY OF ARSENICALS ON HUMAN BRONCHIAL EPITHELIAL CELLS IN VITRO. L. Arnold, S. Kakiuchi-Kiyota, K. L. Pennington and S. M. Cohen. University of Nebraska Medical Center, Omaha, NE. Abstract # #2656 Poster Board Number.....................................267 FORMATION OF TAMOXIFEN (TAM)-DNA ADDUCTS IN MONKEYS AND HUMANS. E. Hernandez Ramon 1 , K. John 1 , R. A. Woodward 2 and M. C. Poirier 1 . 1 NCI/NIH, Bethesda, MD and 2 NICHD/NIH, Poolesville, MD. #2657 Poster Board Number.....................................268 INVOLVEMENT OF CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) IN THE PROCESS OF LIVER HYPERTROPHY AND HEPATOCARCINOGENESIS-INDUCED BY CYP2B-INDUCING NON-GENOTOXIC HEPATOCARCINOGENS IN MICE (2). K. Inoue 1 , M. Yoshida 1 , Y. Sakamoto 1 , M. Takahashi 1 , Y. Taketa 1 , S. Hayashi 1 , S. Ozawa 2 and A. Nishikawa 1 . 1 Division of Pathology, National Institute of Health Sciences, Tokyo, Japan and 2 School of Pharmacy, Iwate Medical University, Iwate, Japan. #2658 Poster Board Number.....................................269 DNA DAMAGE MODULATION IN XPA(-/-) P53(+/-) AND WILD TYPE C57BL/6 MICE FED BENZO[A]PYRENE WITHOUT OR WITH CHLOROPHYLLIN (CHL) FOR 28 DAYS. K. John 1 , M. I. Churchwell 2 , F. A. Beland 2 , M. M. Pratt 3 , G. McMullen 1 and M. C. Poirier 1 . 1 Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 2 Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR and 3 National Center for Environmental Assessment, Office of Research and Development, U.S. EPA, Washington, D.C. #2659 Poster Board Number.....................................270 EXPOSURE TO URBAN PARTICULATE MATTER INDUCES A DECREASE IN E-CADHERIN EXPRESSION IN MULTICELLULAR TUMOR SPHEROIDS. F. M. Bernal-Herrera 1 , C. M. García-Cuéllar 2 , R. Morales-Barcenas 2 , Y. Sánchez-Pérez 2 and Y. I. Chirino 1 . 1 Unidad de Biomedicina, Universidad Nacional Autonoma de Mexico, Edo. Mex, Mexico and 2 Subdirección de Investigación Básica, Instituto Nacional de Cancerologia, Mexico, Mexico. Sponsor: H. Glauert. #2660 Poster Board Number.....................................271 STUDIES ON METABOLISM OF 1, 4-DIOXANE. W. Eck 1 , J. Fishbein 2 , B. Ginevan 2 , N. Koissi 2 and N. Shah 2 . 1 Directorate of Toxicology, U.S. Army Public Health Command, Aberdeen Proving Ground, MD and 2 Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Linthicum, MD. #2661 Poster Board Number.....................................272 THE IN VIVO ROLE OF ADIPOCYTE- SPECIFIC PPARγ IN ENVIRONMENTAL RISK FACTOR-MEDIATED BREAST TUMOURIGENESIS. G. Skelhorne-Gross 1 , N. Peterson 1 , R. Rubino 1 , S. SenGupta 1 and C. Nicol 1,2 . 1 Pathology and Molecular Medicine, Queen’s University, Kingston, ON, Canada and 2 Division of Cancer Biology and Genetics, Queen’s University, Kingston, ON, Canada. Thursday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 353
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 2010-201
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