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50 th Anniversary Annual Meeting and ToxExpo Abstract Key Word Index (Continued) The numerals following each key word refer to the relevant abstract number(s). Key Word Index Covalent Binding.................... 755, 2644 Cox10............................................... 207 COX-2............................................ 1195 CP31398................................... 794, 795 cPLA2 and cytokine IL-8............... 2329 Cramer............................................ 2573 C-reactive protein........................... 2000 creatine........................................... 1928 crisis and emergency risk communication................................. 933 critical effect......................... 1715, 1716 Crohn’s disease............................... 1134 cross species differences....... 1584, 1591 cross-contamination........................ 1932 Crumb Rubber................................ 1568 CrVI.................................................. 919 Cry1C............................................. 1556 cryopreserved hepatocytes.............. 2522 Crystalline Silica.................. 2082, 2318 CSE................................................. 1289 Cu Homeostasis.............................. 2137 Culex............................................... 1436 cumulative.............................. 472, 1794 Cumulative Exposure........... 1580, 1582 cumulative risk assessment.... 864, 1580, 1792, 1793, 1795 cumulative toxicity............................. 20 Curcumin...................... 392, 2233, 2235 curcumin analogs............................ 2635 cutaneous metabolism........................ 86 CW agent........................................ 2021 Cyanide............. 1217, 1260, 1835, 2045 Cyanide antagonism....................... 2046 Cyanide biomarker......................... 1689 Cyanuric Acid......................... 747, 2420 Cyclodextrin................................... 1552 Cyclodextrins.................................... 790 cyclosarin........................................ 2012 Cyclosporine A................................. 739 cynomolgus..................................... 1923 Cynomolgus monkey....... 514, 518, 546, 556, 622, 780, 1046, 1145, 1146, 1232, 1566 Cynomolgus monkeys............ 557, 1061 Cyp................................................. 1675 CYP enzymes................................. 2280 CYP induction................................ 2242 CYP isoform................................... 1846 CYP P450......................................... 141 CYP17............................................ 2547 CYP1A............................................ 1897 CYP1A1...... 199, 309, 364, 1839, 1845, 1852, 1975 Cyp1b1........................................... 1120 CYP2A5................................. 538, 1848 Cyp2b............................................... 553 CYP2B6.......................................... 2103 CYP2B6 polymorphisms................ 1364 CYP2E1.......................... 321, 515, 1843 Cyp2f2................ 582, 1848, 1860, 2643 CYP2F2-knockout.......................... 2643 CYP2S1................................ 1837, 1854 CYP3A4........................................... 422 CYP450................................ 2110, 2234 CYP450 polymorphisms................ 2111 CYPs............................................... 1362 cysteine............................................. 411 Cytochrome b gene......................... 1374 cytochrome c oxidase..................... 2045 Cytochrome P450............ 230, 369, 396, 639, 886, 1100, 1392, 1818, 1820, 1833, 1837, 1838, 1840, 1842, 1844, 1859, 1909, 2079, 2097, 2103, 2220 Cytochrome P450 1A1................... 1841 Cytochrome P450 1A1 (CYP1A1)......................................... 405 Cytochrome P450 2D6..................... 142 Cytochrome P450 2S1.................... 1851 Cytochrome P450 3A4..................... 140 cytochrome P450 reductase............ 1292 Cytochrome P4501A2.................... 1856 cytochrome P450s................ 1850, 1861 cytochromes P450.......................... 1168 cytokeratin 18................................. 1110 cytokine..... 38, 631, 665, 693, 696, 697, 988, 1056 cytokine analysis............................ 2555 cytokine lung.................................... 571 Cytokine release............................... 258 Cytokine Stimulation and SHS....... 1253 cytokines...... 22, 643, 1065, 1140, 2054, 2160, 2325 cytokinesis block method................. 326 Cytoprotection................................ 2498 Cytoskeletal Alterations.................. 2336 Cytotoxic T lymphocyte................... 677 Cytotoxic T Lymphocytes (CTL)..... 683 Cytotoxicity....................... 30, 301, 304, 379, 578, 770, 884, 969, 990, 997, 1176, 1321, 1415, 1480, 2063, 2174, 2179, 2646, 2648, 2655 DACT............................................. 1357 daily inhalation rates......................... 597 danger signals................................. 1505 danio rerio...................................... 1638 Daphnia magna....................... 348, 2382 DART.................................... 1040, 1617 Data Analysis.................................. 1871 Data analysis, pathway analysis........... 4 data integration................................... 85 data mining............................... 148, 158 data sharing....................................... 495 database.................................... 133, 158 database design................................. 155 database development..................... 1540 database overview.......................... 1540 DataChip/MetaChip........................ 2525 DBS (dried blood spot)......... 1230, 1231 DDT............................ 1208, 1833, 2241 deca-brominated diphenyl ether......... 64 Decabromodiphenyl ethane............ 1268 decision analysis............................... 485 Decision Support.............................. 480 Decision Tree............................ 470, 482 decision tree algorithm..................... 469 decitabine.......................................... 799 Decontamination............................. 2021 deer mice.......................................... 551 deferoxamine.................................. 2578 DEHP.............................. 496, 617, 1824 Delayed neurotoxicity.................... 1381 Delayed-type hypersensitivity........... 80, 1145 Delta-9-tetrahydrocannabinol........... 677 dendrimers...................................... 2173 Dendrite Growth............................. 2624 dendritic cell............................. 94, 1130 dendritic cells....... 652, 675, 1129, 1131, 1175, 2527 dental.............................................. 1317 dental material................................ 1318 deoxynivalenol............. 516, 1662, 2419 Depleted Uranium.................... 281, 283 depression-like behavior................. 2606 depurinating estrogen DNA adducts.............................................. 880 derivatives....................................... 2424 Dermal...................................... 635, 890 dermal absorption........................... 1251 Dermal Irritation....................... 467, 989 dermal penetration............................ 640 Dermatitis......................................... 643 dermatotoxicity............................... 2028 DES................................................. 2192 detecting unexpected protein modifications.................................... 128 developing brain............................. 2598 Development.... 1609, 1629, 1635, 1647, 1698, 2150, 2197, 2198, 2389 development exposure.................... 1989 Developmental........... 1029, 1325, 1615, 1644, 2618 Developmental & Reproductive toxicity.... 1034, 1073, 1560, 2095, 2192 developmental and reproductive toxicity.................................. 1027, 2662 developmental database.................... 495 developmental exposure........ 873, 1641, 2189 Developmental Immunotoxicity....... 662 Developmental immunotoxicology.......................... 2666 Developmental neurotoxicity.... 31, 867, 869, 871, 1332, 1352, 1391, 2601, 2602, 2603, 2604, 2605, 2614, 2622, 2628, 2629 Developmental Neurotoxicology......... 2450, 2452, 2590 Developmental Origins of Adult Disease 1697, 1701, 2188, 2194, 2662 Developmental Teratology............. 1623 developmental toxicity.......... 71, 73, 76, 836, 838, 840, 898, 991, 1044, 1075, 1619, 1630, 2370, 2626 Developmental Toxicology........ 72, 105, 158, 1614, 1621, 1637 Developmental, Energy Metabolism/Disregulation.............. 2248 Dextran-40...................................... 1160 DFP................................................... 167 DHA................................................ 2193 Di (n-butyl) phthalate..................... 2191 di(2-ethylhexyl) phthalate.............. 1846 diabetes............................ 145, 149, 267, 609, 752, 1077, 1079, 1294, 1980, 2001, 2255, 2270, 2347, 2471, 2583 diabetes mellitus............................. 2472 Diabetes stress................................ 2584 diabetic inflammation..................... 2593 diabetic nephropathy........................ 756 diagnostic........................................ 2314 diazepam......................................... 2394 Dibenzo(def, p)chrysene................... 699 Dibenzofuran.................................. 1087 dibutylphthalate.............................. 1041 Dichloroacetate................................. 251 Dichloro-diphenyldichloroethylene............................... 403 Dichlorvos...................................... 2099 diclofenac......................................... 766 Dicyclohexylamine........................... 642 diesel......................................... 568, 570 diesel exhaust........... 565, 605, 606, 607, 608, 1472 diesel exhaust particle(s)......... 604, 609, 901,1234, 2334 Diesel Exhaust Particulate.............. 2328 dietary exposure...................... 611, 1526 Dietary intake................................. 2412 Dietary Phytochemicals.................... 110 dietary risk...................................... 1796 dietary supplement(s)........... 2418, 2435 Diethylenetriamine trinitrate.......... 1420 diethylnitrosamine............................ 321 Diethylstilbestrol............................ 2188 differentially expressed genes........ 2598 differentiation......................... 222, 2366 digestibility......................................... 96 Diisocyanates.................................. 1367 DIKI...................................... 1430, 1602 DILI........................ 431, 536, 970, 1895 Dioxanone....................................... 2660 dioxin....................... 349, 350, 356, 474, 654, 976, 1121, 1125, 1126, 1158, 1628, 1959, 1961, 2255, 2354, 2355 dioxin-like compound........... 1365, 1366 Dioxins........................................... 1265 Dioxins and furans.................. 361, 1246 dipentyl phthalate........................... 2663 Diphenhydramine........................... 2400 diphenylditelluride............................ 302 diphenyliodoinum chloride............. 2417 Discovery........................................ 2676 disease model.................................... 187 Disease Prevention............................. 40 disease risk...................................... 1702 disease risk factor........................... 1198 disease-environment interactions... 1774 diseases............................................. 528 dispersants.............................. 825, 2341 Dispersibility.................................. 1480 Disposition......... 732, 1080, 2043, 2044, 2275, 2276 distribution.................. 1194, 2174, 2277 dithiocarbamates............................. 1347 diuron dose-response........................ 525 Division.......................................... 2671 DMAE............................................ 2277 DMEL............................................. 1516 DMSO............................................. 1422 DNA Adduct................. 486, 1690, 2642 DNA adducts........................ 1683, 1691 DNA binding................ 319, 2640, 2644 DNA damage................................... 117, 122, 265, 323, 325, 329, 338, 342, 1373, 1548, 2027, 2071, 2640, 2652 DNA double strand breaks.............. 2164 DNA interaction................................ 481 DNA methylation..... 102, 815, 942, 943, 944, 946, 950, 1616, 1720, 1987 DNA microarray............................. 1605 DNA Repair............. 114, 117, 283, 954, 1976, 2636 DNA repair capacity....................... 1360 DNA sequence................................ 2441 DNA strand breaks......................... 1303 DNA Synthesis................................. 122 DNEL................................................ 499 DNT................................................ 2595 Docking............................................ 149 Dog................. 211, 520, 560, 619, 2285 Dogs.................................................. 528 DOHaD........................................... 2185 Domoic acid.................................... 2621 dopamine..... 168, 346, 506, 1378, 1394, 2149, 2399, 2579 Dopamine neuron........................... 1400 dopamine transporter.............. 868, 1347 dopaminergic.................................... 872 dopaminergic neurons....................... 980 dopaminergic toxicity..................... 1357 Dopaminergics................................ 2372 Dose Addition................................. 2306 dose reconstruction......................... 1810 Dose response...................... 1960, 2161, 2507, 2639 dose response modeling.......... 478, 1978 Dose-Dependent Transitions.......... 1719 Dose-Limiting Toxicity.................. 1524 Dose-Response........ 332, 473, 475, 477, 733, 917, 1248, 1273, 2255, 2420 dosimetry..... 595, 850, 851, 1475, 2118, 2699 dosimetry of nanomaterials.............. 846 doubly labeled water................. 597, 598 Doxorubicin................... 104, 204, 1855, 1884, 1888 Draize............................................. 2568 Draize Alternative............................. 466 dried blood spot.......... 1232, 1926, 2284 Dried Blood Spot (DBS).................. 517 drinking water.... 997, 1221, 1531, 1532, 1536, 1542, 1951, 1952, 2443 Drinking water limit................... 6, 1536 Drosophila............................ 1978, 2445 drug........................................... 435, 443 drug abuse liability......................... 1722 drug abuse potential........................ 1722 Drug cardiotoxicity............... 1165, 1894 drug delivery............................. 350, 653 390 SOT 50th Anniversary Annual Meeting
Society of Toxicology 2011 Abstract Key Word Index (Continued) The numerals following each key word refer to the relevant abstract number(s). drug development...... 1148, 1804, 1807, 1808, 1896 drug discovery...................... 2519, 2678 Drug Disposition............................ 1915 drug dose-response relationship..... 1575 Drug hypersensitivity reactions............ 7 Drug impurities........................... 6, 1812 Drug induced liver injuries (DILI)... 940 drug induced liver injury.................. 438 Drug induced liver injury (DILI)..... 409, 425, 427, 446, 878, 2511 drug interaction............................... 1844 Drug metabolism.................... 534, 1097 Drug metabolizing enzymes............ 615, 1855 drug metabolizing enzymes, transporters..................................... 2266 Drug of abuse................................. 1834 drug processing genes....................... 449 Drug Products................................. 2573 Drug residues.................................... 710 drug screening...................... 1898, 2677 drug transporters......... 1058, 1108, 1915 drug-drug interaction...................... 2280 Drug-drug Interactions..................... 381 drug-induced hepatotoxicity..... 431, 463 drug-induced liver injury......... 138, 423, 428, 435, 934 Drug-induced Phospholipidosis........ 137 drug-induced vascular injury......... 2669, 2670, 2672, 2674 Drug-related adverse events..... 549, 854 Drywall........................................... 1214 Duodenum........................................ 269 duox.................................................. 631 dyslipidemia................................... 1115 dysrhythmia.................................... 2114 E2F/Rb/HDAC1/2............................ 406 E7 oncoprotein.................................. 406 EAAT1/GLAST................................ 394 early age............................................ 701 Early Safety...................................... 784 Early safety profiling................ 479, 855 Earthworms..................................... 2406 ECa233........................................... 1842 E-cadherin....................................... 2659 ECC1 cell line................................. 2355 ECG.............. 195, 562, 570, 1919, 2359 economic adulteration.................... 2415 economy......................................... 2481 Ecotoxicity.................... 327, 1482, 2465 ecotoxicology........ 16, 826, 2397, 2462, 2463, 2464, 2467 EDSP.................................... 2358, 2559 education.................... 1866, 1870, 1872, 1875, 1880 Education and Career Development..................................... 419 Education and Outreach....... 1865, 1869 EEG...................................... 1355, 1806 EFT-300.......................................... 2556 EGCG............................................... 212 EGFR................................................ 776 Egypt..................................... 1216, 1218 eicosanoids..................................... 1837 elastase............................................ 1652 Elastomer........................................ 1550 Electrocardiographic......................... 558 electrophile..................................... 1787 Electrophoresis............................... 1374 Electroretinogram............................. 520 electroretinography........................... 793 elimination...................................... 1460 Embryo implantation...................... 1025 Embryo toxicity.............................. 2391 embryogenesis................................ 1634 embryonic development.......... 410, 839, 1616, 2445 embryonic stem cell.......................... 979 embryonic stem cell differentiation.... 76 embryonic stem cell test....... 73, 75, 991 Embryonic stem cells....... 77, 837, 1019 embryotoxicity........................ 979, 1045 emerging science.............................. 883 Employment................................... 1879 EMS................................................ 1405 EMT.................................................. 953 encapsulation.................................. 1358 endocannabinoid............................. 2611 endocannabinoids........................... 2086 Endocrine................ 18, 246, 2094, 2559 endocrine active agent...................... 623 endocrine active substances............ 2466 endocrine disrupter................. 692, 1537 Endocrine disrupters....................... 2373 endocrine disrupting (ED) activity............................................ 2367 endocrine disruption........ 67, 494, 1066, 2202, 2346, 2348, 2351, 2358 endocrine disruptor...... 624, 2092, 2186, 2349, 2352, 2375, 2383, 2388, 2602, 2603, 2667 Endocrine disruptor screening........ 2375 endocrine disruptors...... 531, 730, 1016, 1017, 1047, 2344, 2362, 2429 endocrine mode of action................. 622 Endocrine Disrupting Chemicals.... 2091 endocrine-disrupting chemicals (EDCs)............................................ 2367 endogenous AHR ligand....... 1839, 1845 Endometriosis................................. 2355 endoplasmic reticulum (ER) stress............................................... 1998 Endoplasmic Reticulum Stress........ 252, 2030 Endorphins...................................... 2377 endothelial...................... 189, 262, 1493 endothelial cell.............. 212, 2180, 2633 Endothelial cell function................. 2066 Endothelial Cells............ 191, 455, 2250 endothelial dysfunction............ 186, 581 Endothelial function......................... 554 endothelial progenitor cell.............. 2058 endothelial progenitor cells............ 1170 endothelin-1.................................... 1076 Endothelium..................................... 959 Endotoxins........................................ 668 energetic.......................................... 1544 energy............................................. 1535 energy metabolism.......................... 2315 energy policy.................................. 2589 engine emission.............................. 1413 engine emissions............................. 1555 engineering..................................... 1730 Entomopathogenic nematodes........ 1250 ENU................................................ 1406 environmental................................. 2394 environmental cardiology............... 1170 Environmental Contaminants......... 1579 environmental effects..................... 1489 environmental epigenetics................ 102 environmental exposure.................. 1970 environmental health.............. 883, 1873 Environmental monitoring.............. 1246 Environmental oxidants...................... 23 Environmental pollutants................ 1567 Environmental predictors............... 1567 Environmental Statistics................... 714 environmental tobacco smoke......... 186, 1253, 1254 environmental toxicants.................... 819 environmental toxicology............... 1257 enzyme inhibition........................... 2098 Enzyme replacement therapy........... 791 Enzymes......................................... 2381 eosinophil peroxidase......................... 54 EPA................................................. 2559 EPA standard................................... 1223 epidemiological study....................... 292 Epidemiology........ 47, 48, 49, 50, 1198, 1207, 1258, 1946, 1956 EPIDERM............................. 2535, 2560 Epidermal Growth Factor Receptor.......................................... 2345 epidermal model............................... 322 epigenetic.............. 106, 813, 1771, 2520 epigenetic changes............................ 108 epigenetic regulation.............. 949, 2666 epigenetic toxicity............................ 123 Epigenetics...... 5, 12, 42, 100, 103, 105, 109, 110, 814, 817, 883, 946, 947, 950, 1167, 1621, 1700, 2071, 2187 Epigenomics............................. 12, 1720 epilepsy................................. 2020, 2037 EpiOcular.......................................... 644 Episkin............................................ 2535 Epithelial Lung Cells........................ 983 epoxide........................................... 1843 eQTL................................................... 41 equine flesh..................................... 1211 ER binding affinity........................... 494 ER stress....... 37, 262, 1083, 2224, 2532 ErbB2................................................ 206 ErbB3................................................ 776 Erionite........................................... 1267 ERK.......................................... 276, 404 ERK1/2 mediated inflammation..... 2329 ER-negative.................................... 2634 ER-negative breast cancer.............. 2635 ER-negative xenograft.................... 2635 ER-stress; MAPK............................. 307 Erythrophagocytosis......................... 294 ESL................................................. 1523 Essential oils................................... 2236 essentiality...................................... 2459 esterases.......................................... 2047 Estrogen......... 19, 172, 624, 1023, 1043, 1064, 1272, 2344, 2364, 2365 Estrogen carcinogenesis................... 227 estrogen mediated........................... 2303 estrogen receptor........... 144, 372, 1016, 1017, 1708 estrogen receptor activation............ 2357 estrogen receptor beta..................... 2365 Estrogenic Activity................. 860, 2429 Estrogens...................................... 17, 21 estrus cycle..................................... 1042 ETBE...................................... 515, 1531 ethanol......... 679, 707, 968, 1082, 1301, 1302, 2147, 2620 ethinylestradiol................................. 113 EthoVision XT.................................. 780 Ethyl Glurcuronide......................... 1819 Ethyl tert-butyl ether (ETBE)......... 1490 ethylene bisdithiocarbamate........... 2087 ethylene glycol poisoning................. 758 Ethylenediamine dinitrate............... 1420 europe............................................. 1877 Everyday compounds..................... 2351 Evidence Combination..................... 729 evolution......................................... 1729 ex vivo............................................... 823 EXCELERITE................................ 2228 Excipients............................... 507, 1928 Excitatory amino acid..................... 1571 excretion......................................... 1194 Exercise............................................ 537 Exhaled breath................................ 2301 Exhaled Breath Condensate pH...... 1212 Exosomes.......................................... 680 experimental autoimmune encephalomyelitis........................... 1507 Experimental Design...................... 2306 export................................................ 312 Exposome............................... 42, 44, 46 Exposomics......................................... 43 exposure....... 51, 824, 1181, 1224, 1243, 1244, 1259, 1794 exposure assessment.................. 50, 700, 731, 1239, 1251, 1258, 1262, 1545, 2118, 2504 exposure at schools........................... 498 exposure model............................... 1266 exposure risk................................... 1264 exposure science................................. 52 exposure-based testing.................... 1522 expression profiling........................ 1410 Extended one generation study........ 664, 1030, 2615, 2616 Extractable and Leachable.............. 1315 extractable/leachable...................... 1323 Extrapolation...................... 2, 938, 2476 eye..................................................... 793 eye irritant....................................... 1521 eye irritation.................. 996, 1553, 2545 F1...................................................... 663 F1-extended one generation study............................................... 1560 Factor XI........................................... 216 FAS................................................. 2215 FAS Facial anomalies in rats.......... 1640 FasL................................................ 1657 Fasting.................................. 2499, 2586 fathead minnow.............................. 2368 fatty acids........................................ 2531 fau................................................... 1673 FceRI.............................................. 2218 FDA guidelines............................... 1723 Fe-depleted....................................... 769 Feed Refusal................................... 2419 Feed restriction............................... 1574 female............................................. 1024 female puberty................................ 1042 female reproduction........................ 1061 Females/Gender Differences............ 583 Fenvalerate..................................... 1070 Ferritin.................................. 2003, 2497 ferroportin......................................... 312 Fertility....................... 1040, 1050, 1923 fetal....................................... 1022, 1635 fetal basis of adult disease.... 1043, 2191 Fetal Growth................................... 1645 fetal growth restriction................... 2085 fetal liver......................................... 2185 Fetal programming............................. 15 fetal testis........................................ 1611 fetal toxicity.................................... 2095 FFPE tissue..................................... 1590 Fiber depositin in the lung.............. 2292 fiber equivalent diameter................ 2293 Fiber inhalability.................. 2292, 2293 fiber pleura toxicology..................... 600 fiber separation............................... 2293 Fibrinogen......................................... 765 Fibroblast.......................................... 303 Fibroblast Cells............................... 2341 Fibrogenic Mediators...................... 1183 fibrosis................ 602, 1082, 1119, 2178 FICZ..................................... 1132, 1845 FICZ, 6-formylindolo[3, 2-b] carbazole............................... 1839, 1852 Fipronil........................................... 1355 Fire causalities................................ 1217 Fire Sleeve...................................... 1247 First-Pass Elimination.................... 1817 fish.................... 1537, 2384, 2391, 2465 Fish advisory.................................. 1572 fish and amphibians........................ 2466 fish consumption.................. 1256, 1572 fish consumption advisory.............. 1249 Fish model...................................... 1777 Fish Testing..................................... 2467 Fisher 344 rat.................................... 245 Fishing survey................................ 1572 flame retardant...................... 2253, 2640 Flame Retardants.................... 869, 2379 flavonoids......................................... 616 Key Word Index up-to-date information at www.toxicology.org 391
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 Map of W
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 2011 Awa
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Endowment Awardees for SOT’s 50 t
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Society of Toxicology 2011 SOT Endo
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 RC, SIG,
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Poster S
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Society of Toxicology 2011 Program
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Page 361 and 362: Society of Toxicology 2011 Program
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