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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # #1088 Poster Board Number.....................................412 REGULATION OF LIVER FLAVIN- CONTAINING MONOOXYGENASE 3 (FMO3) GENE EXPRESSION UNDER OXIDATIVE STRESS CONDITIONS. S. Rudraiah 1 , X. Gu 1 , L. M. Aleksunes 2 , S. Campion 1 , R. N. Hines 3 and J. E. Manautou 1 . 1 Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 2 Department of Pharmacology & Toxicology, Rutgers University, Piscataway, NJ and 3 Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI. #1089 Poster Board Number.....................................413 PFOA-INDUCED LIVER EFFECTS IN CD-1 AND PPAR-ALPHA KNOCK-OUT C57BL/6 MICE. A. J. Filgo 1,2 , M. J. Hoenerhoff 2 , G. E. Kissling 2 , S. S. White 2 , E. P. Hines 3 , J. P. Stanko 2 and S. E. Fenton 2 . 1 Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2 CMPB, NTP, NIEHS, Research Triangle Park, NC and 3 NCEA, ORD, U.S. EPA, Research Triangle Park, NC. #1090 Poster Board Number.....................................414 INVOLVEMENT OF CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) IN THE PROCESS OF LIVER HYPERTROPHY AND HEPATOCARCINOGENESIS-INDUCED BY CYP2B-INDUCING NON-GENOTOXIC HEPATOCARCINOGENS IN MICE (1). Y. Sakamoto 1 , M. Yoshida 1 , K. Inoue 1 , M. Takahashi 1 , Y. Taketa 1 , S. Hayashi 1 , S. Ozawa 2 and A. Nishikawa 1 . 1 Division Pathology, NIHS, Setagaya, Tokyo, Japan and 2 School of Pharmacology, Iwate Medical University, Morioka, Iwate, Japan. #1091 Poster Board Number.....................................415 EXPOSURE TO TCDD INCREASES HEPATIC STELLATE CELL PROLIFERATION AND ACTIVATION. W. A. Harvey, C. J. Doolittle and K. A. Mitchell. Biology, Boise State University, Meridian, ID. #1092 Poster Board Number.....................................416 DETERMINATION OF IN VIVO KUPFFER CELL FUNCTIONS BY CONTRAST ENHANCED ULTRASOUND (CEUS) IMAGING. V. Joaquin 1 , T. Tomoo 1 , E. Skuba 5 , T. Wang 3 , V. Richard 4 , S. Chibout 2 , F. Pognan 2 , N. Shangari 1 and A. Wolf 2 . 1 iTOX, Preclinical Safety (PCS), Novartis Institutes of Biomedical Research (NIBR), East Hanover, NJ, 2 iTOX, PCS, NIBR, Basel, Switzerland, 3 PCS, NIBR, Emmeryville, CA, 4 iTOX, PCS, NIBR, Cambridge, MA and 5 PCS, NIBR, East Hanover, NJ. #1093 Poster Board Number.....................................417 TCDD ENHANCES THE RESPONSE OF INNATE IMMUNE CELLS TO CONCANAVALIN A ADMINISTRATION. A. M. Fullerton, R. A. Roth and P. E. Ganey. Department Pharmacology & Toxicology, Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1094 Poster Board Number.....................................418 A MICROPATTERNED HUMAN HEPATOCYTE CO-CULTURE MODEL ALLOWS DETERMINATION OF TOXICITY AT MORE RELEVANT CONCENTRATIONS THAN HEPATOCYTE SANDWICH CULTURES. D. Keller 1 , S. Krzyzewski 2 and S. Khetani 2 . 1 Preclinical Safety, sanofi-aventis U.S., Malvern, PA and 2 Hepregen Corp., Medford, MA. #1095 Poster Board Number.....................................419 DEVELOPMENT OF AN IN VITRO HEPATOCYTE MODEL TO INVESTIGATE CHEMICAL MODE OF ACTION. S. D. Hester 1 , J. Harrill 1 , C. Corton 1 and L. Murphy 2 . 1 Systems Biology Branch, U.S. EPA, Durham, NC and 2 Carcinogenesis, U.S. EPA, Durham, NC. #1096 Poster Board Number.....................................420 QUANTITATIVE (Q)PCR ANALYSIS OF RNA EXTRACTED FROM FORMALIN- FIXED PARAFFIN EMBEDDED (FFPE) LIVER FROM AFLATOXIN B1 (AFB1) TREATED RATS: CORRELATION WITH MICROARRAY DATA. B. A. Merrick, S. S. Auerbach, P. S. Stockton, J. F. Foley, D. E. Malarkey, R. C. Sills, R. D. Irwin and R. R. Tice. National Toxicology Program, NIEHS/NIH, Research Triangle Park, NC. #1097 Poster Board Number.....................................421 SIMILARITIES AND DIFFERENCES IN THE EXPRESSION OF DRUG METABOLIZING ENZYMES BETWEEN HUMAN HEPATIC CELL LINES AND PRIMARY HUMAN HEPATOCYTES. L. Guo, S. Dial, L. Shi, W. Branham, J. Fang, B. Green, J. Kaput and B. Ning. NCTR, Jefferson, AR. #1098 Poster Board Number.....................................422 ENHANCEMENT OF NATURALLY OCCURRING BASOPHILIC FOCI IN THE LIVERS OF HAN WISTAR RATS TREATED WITH AZD9056. P. A. Duffy, J. G. Evans, P. J. Kerry, M. O’Donovan, M. Coulson and H. Powell. Global Safety Assessment, AstraZeneca, Macclesfield, Cheshire, United Kingdom. #1099 Poster Board Number.....................................423 THE EFFECT OF VITAMIN E DEFICIENCY ON D.C.A- AND TCA-INDUCED OXIDATIVE STRESS IN THE LIVERS OF MALE B6C3F1 MICE FOLLOWING SUBCHRONIC EXPOSURE. J. Cearfoss and E. Hassoun. Pharmacology, University of Toledo, Toledo, OH. #1100 Poster Board Number.....................................424 O- AND N-DEMETHYLATION OF LEVOMETHORPHAN BY HUMAN CYTOCHROME P450 ENZYMES. M. Sunouchi 1 , A. Miyajima-Tabata 2 , R. Kikura-Hanajiri 3 and Y. Goda 3 . 1 Division of Pharmacology, National Institute of Health Sciences, Tokyo 158-8501, Japan, 2 Division of Medical Devices, National Institute of Health Sciences, Tokyo 158-8501, Japan and 3 Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, Tokyo 158- 8501, Japan. Sponsor: A. Hirose. 212 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1101 Poster Board Number.....................................425 EFFECT OF ACARBOSE ON ALANINE AMINOTRANSFERASE 1 AND 2 PROTEINS AND GLUCONEOGENESIS IN RAT TISSUES. K. Kumagai, S. Arakawa, T. Matsuyama, K. Kai, M. Teranishi and A. Sanbuissho. Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Shizuoka, Japan. #1102 Poster Board Number.....................................426 ENZYMES AND OXIDATIVE DAMAGE INDICATORS IN RATS FOLLOWING SUBACUTE OR SUBCHRONIC MANGANESE CHLORIDE EXPOSURE. P. Huang 1 , G. Li 2 and Z. Sun 1 . 1 Department of Toxicology and Sanitary Chemistry, School of Public Health and Family Medicine, Capital Medical University, Beijing, China and 2 Beijing Research Center for Preventive Medicine, Beijing, China. Sponsor: W. Zheng. #1103 Poster Board Number.....................................427 THE ROLE OF 3, 3’, 4, 4’, 5-PENTACHLOROBIPHENYL (PCB 126) IN COPPER DISPOSITION IN RODENT LIVER. M. Li 1,2 , I. Lai 1,2 , B. Wels 3 , D. Simmons 3 , G. Ludewig 1,2 and L. Robertson 1,2 . 1 Interdisciplinary Program in Human Toxicology, University of Iowa, Iowa City, IA, 2 Occupation and Environmental Health, University of Iowa, Iowa City, IA and 3 State Hygienic Laboratory, University of Iowa, Iowa City, IA. #1104 Poster Board Number.....................................428 ENTEROHEPATIC CIRCADIAN RHYTHM IN MICE: CONTRIBUTIONS OF BILE ACIDS. Y. J. Zhang, G. L. Guo and C. D. Klaassen. Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS. #1105 Poster Board Number.....................................429 MYELOPEROXIDASE-DEPENDENT METABOLISM OF P-CRESOL: A NOVEL PATHWAY FOR XENOBIOTIC AND ENDOBIOTIC BIOTRANSFORMATION DURING INFLAMMATION. J. Houghton 1 , K. Hayakawa 1 , D. DeGroot 2 , B. Zhao 2 , M. Denison 2 and J. P. Eiserich 1 . 1 Department of Internal Medicine, University of California Davis, Davis, CA and 2 Department of Environmental Toxicology, University of California Davis, Davis, CA. #1106 Poster Board Number.....................................430 TOXICITY, TOXICOGENOMIC, AND METABOLOMIC STUDY OF PENTAMETHYLCHROMANOL. T. Parman 1 , D. Bunin 1 , H. H. Ng 1 , T. Harrison 1 , J. McDunn 2 , I. M. Kapetanovic 3 and C. E. Green 1 . 1 Biosciences, SRI International, Menlo Park, CA, 2 Metabolon, Inc., Durham, NC and 3 National Cancer Institute, Bethesda, MD. #1107 Poster Board Number.....................................431 EVIDENCE OF PEPPERMINT OIL SKIN PENETRATION AND CYTOTOXICITY ON RAT HEPATOCYTES IN VITRO. M. Dong 1 , O. Weber 1 , E. Di Lenarda 1 , P. End 2 , S. Chibout 1 , A. Wolf 1 and F. Pognan 1 . 1 Preclinical Safety, Novartis, Basel, Switzerland and 2 Drug Metabolism and Pharmacokinetics, Novartis, Basel, Switzerland. Abstract # Tuesday Morning, March 8 9:00 AM to 12:30 PM Exhibit Hall Poster Session: Cholestasis, Lipid Homeostasis, and Liver Toxicity Chairperson(s): Rhiannon Hardwick, University of Arizona, Tucson, AZ. Displayed: 9:00 AM–12:30 PM Author Attended: 11:00 AM–12:30 PM #1108 Poster Board Number.....................................436 MOLECULAR MECHANISM OF ALTERED EZETIMIBE DISPOSITION IN NON- ALCOHOLIC STEATOHEPATITIS. R. N. Hardwick, C. D. Fisher, S. M. Street, M. J. Canet and N. J. Cherrington. Pharmacology and Toxicology, University of Arizona, Tucson, AZ. #1109 Poster Board Number.....................................437 DIETARY N-ACETYLCYSTEINE (NAC) REDUCES HEPATOCELLULAR LIPID ACCUMULATION FOLLOWING 3, 3’, 4, 4’, 5-PENTACHLOROBIPHENYL (PCB 126) EXPOSURE. I. Lai 1,2 , A. Olivier 3 , M. Li 1,2 , K. Dhakal 1,2 and L. Robertson 1,2 . 1 Occupation and Environmental Health, University of Iowa, Iowa City, IA, 2 Interdisciplinary Program in Human Toxicology, University of Iowa, Iowa City, IA and 3 Department of Pathology, University of Iowa, Iowa City, IA. #1110 Poster Board Number.....................................438 SERUM CYTOKERATIN 18 AND CYTOKINE ELEVATIONS SUGGEST A HIGH PREVALENCE OF OCCUPATIONAL LIVER DISEASE IN ELASTOMER / POLYMER WORKERS HIGHLY-EXPOSED TO ACRYLONITRILE, BUTADIENE, AND STYRENE. M. Cave 1,2 , K. Falkner 1 , B. Costello 1 , B. Gregory 1 , L. Henry 1 and C. McClain 1,2 . 1 Department of Medicine/GI, University of Louisville, Louisville, KY and 2 Robley Rex Veterans Administration Medical Center, Louisville, KY. #1111 Poster Board Number.....................................439 MITOCHONDRIAL TOXICITY OF CHLOROACETALDEHYDE IN HEPG2 CELLS. K. Falkner 1 , B. Hill 1 , B. Sansbury 1 , J. Gaurdiola 1 , C. McClain 2 and M. Cave 2 . 1 Department of Medicine/GI, University of Louisville, Louisville, KY and 2 Louisville VA Medical Center, Louisville, KY. #1112 Poster Board Number.....................................440 HGF ALTERED RESPONSE IN HIGH CHOLESTEROL FEED MICE HEPATOCYTES. M. Dominguez, N. Nuño, D. Clavijo, C. Enriquez, V. Souza, L. Bucio, L. Gomez Quiroz and C. Gutierrez-Ruiz. Health Sciences, Universidad Autónoma Metropolitana Iztapalapa, Mexico, Mexico. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 213
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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