Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#2525 Poster Board Number.....................................117
DATACHIP/METACHIP 2.0: AN IMPROVED
CHIP PLATFORM FOR 3D CELL-BASED
TOXICOLOGY ASSAYS. ​M. Lee 1 , J. Ryan 1 ,
S. Brooks 1 , J. Gray 1 , D. Lee 2 , S. Jeong 2 , J. Yang 2 ,
B. Ku 2 , Y. Will 3 and S. Nadanaciva 3 . 1 Solidus
Biosciences, Inc., San Francisco, CA, 2 Central R &
D Institute, Samsung Electro-mechanics Co., Suwon,
Republic of Korea and 3 Compound Safety Prediction,
Pfizer Inc., Groton, CT.
#2526 Poster Board Number.....................................118
HIGH-THROUGHPUT GENE
TRANSFECTION ON A THREE-
DIMENSIONAL (3-D) CELL MICROARRAY
PLATFORM FOR METABOLISM-INDUCED
TOXICOLOGY SCREENING. ​S. Kwon 1 , J.
Gray 2 , B. Ku 3 , J. Ryan 2 , D. Clark 4 , J. Dordick 1 and
M. Lee 2 . 1 Department of Chemical and Biological
Engineering, Rensselaer Polytechnic Institute, Troy,
NY, 2 Solidus Biosciences, Inc., San Francisco,
CA, 3 Central R & D Institute, Samsung Electro-
Mechanics Co., Suwon, Republic of Korea and
4
Department of Chemical Engineering, University of
California Berkeley, Berkeley, CA.
#2527 Poster Board Number.....................................119
CELL TOXICITY AND INTERLEUKIN (IL)
8 PRODUCTION: UNIQUE RELATIONSHIP
WITH ALLERGENICITY. ​I. Kimber 1 , C.
F. Portsmouth 1 , R. Pendlington 2 , G. Maxwell 2
and R. J. Dearman 1 . 1 University of Manchester,
Manchester, United Kingdom and 2 Unilever Safety
& Environmental Assurance Centre, Bedford, United
Kingdom.
#2528 Poster Board Number.....................................120
SCREENING DRUG-INDUCED
MITOCHONDRIAL TOXICITY USING A
HIGH-THROUGHPUT DUAL-PARAMETER
CELL BASED ASSAY. ​J. Hynes 2 , C. Carey 2 , S.
Kirwan 2 , R. Swiss 1 and Y. Will 1 . 1 Compound Safety
Prediction, Pfizer Global Research & Development,
Groton, CT and 2 Luxcel Biosciences, Cork, Ireland.
#2529 Poster Board Number.....................................121
USING MULTIPLE ASSAYS TO ASSESS
DRUG-INDUCED MITOCHONDRIAL
TOXICITY IN EARLY TOXICOLOGY
TESTING. ​R. Swiss, P. Rana and Y. Will.
Compound Safety Prediction, Pfizer Global Research
& Development, Groton, CT.
#2530 Poster Board Number.....................................122
JC-1 MITOCHONDRIAL MEMBRANE
POTENTIAL MEASUREMENTS OF
H9C2 CELLS GROWN IN GLUCOSE
AND GALACTOSE CONTAINING
MEDIA DOES NOT PROVIDE
ADDITIONAL PREDICTIVITY TOWARDS
MITOCHONDRIAL TOXICITY
ASSESSMENT. ​P. Rana, Y. Will and S.
Nadanaciva. Compound Safety Prediction, Pfizer
Global Research & Development, Groton, CT.
#2531 Poster Board Number.....................................123
TREATMENT OF FATTY ACIDS INCREASES
THE SUSCEPTIBILITY OF CELLS TO
TOXIC COMPOUND INDUCED INJURY. ​
Y. Luo, P. Rana and Y. Will. Compound Safety
Prediction, Pfizer Global Research & Development,
Groton, CT.
Abstract #
#2532 Poster Board Number.....................................124
ER-STRESS AS A CONTRIBUTOR TO
HEPATOTOXICITY: DEVELOPMENT OF
A SCREENING PARADIGM. ​T. Schroeter, L.
Qui, M. Pletcher and Y. Will. Compound Safety
Prediction, Pfizer Global Research & Development,
Groton, CT.
#2533 Poster Board Number.....................................125
HIGH-CONTENT IMAGING ASSAY
FOR DETECTING ACCUMULATION
OF COMPOUNDS IN LYSOSOMES. ​S.
Nadanaciva 1 , S. Lu 2 and Y. Will 1 . 1 Compound Safety
Prediction, Pfizer Global Research & Development,
Groton, CT and 2 DSRD, Pfizer Global Research &
Development, La Jolla, CA.
#2534 Poster Board Number.....................................126
CUTANEOUS WOUND HEALING IN THE
EPIDERM-FT FULL-THICKNESS IN
VITRO HUMAN SKIN MODEL. ​P. J. Hayden,
A. Armento, C. Cooney, G. Stolper, M. Li, H.
Kandarova and M. Klausner. MatTek Corporation,
Ashland, MA.
#2535 Poster Board Number.....................................127
EVALUATION OF EPISKIN AND EPIDERM
SKIN IRRITATION METHODS FOR
TESTING SILICON-BASED MATERIALS. ​M.
L. Jovanovic, J. Arthurton and P. Jean. Dow Corning,
Auburn, MI.
#2536 Poster Board Number.....................................128
COMPARISON OF FCM AND ELISA IN
THE EVALUATION OF THE OF SKIN
SENSITIZATION BY NON-RADIOACTIVE
MURINE LOCAL LYMPH NODE ASSAY
USING BROMODEOXYURIDINE. ​Y. Yum 1 ,
Y. Lee 1 , K. Jung 2 , K. Lim 2 , J. Park 1 , H. Park 1 , J.
Kim 1 , J. Yang 1 , S. Sohn 1 , J. Chung 3 and S. Han 1 .
1
Toxioclogical Evaluation and Research Department,
National Institute of Drug and Food Safety
Evaluation, Seoul, Republic of Korea, 2 Amorepacific
Corporation R&D Center, Yougin-si, Republic of
Korea and 3 College of Pharmacy, Seoul National
University, Seoul, Republic of Korea.
#2537 Poster Board Number.....................................129
ADAPTATION OF THE RAT HEPATOCYTES
LONG-TERM CULTURE FOR HIGH-
CONTENT IMAGING TO PREDICT
CHRONIC LIVER TOXICITY IN VITRO. ​G.
Davide, C. Zehnacker, P. Couttet, S. Chibout, O.
Grenet, M. Uteng, F. Pognan, M. Dong and A. Wolf.
Translational Sciences/Investigative Toxicology,
Novartis Institute for Biomedical Research (NIBR),
Basel, Switzerland.
#2538 Poster Board Number.....................................130
AN IN SILICO APPROACH FOR
COMPUTING OCCUPATIONAL EXPOSURE
LIMITS OF ORGANIC SOLVENTS. ​M.
Debia and K. Krishnan. Département de Santé
Environnementale et Santé au Travail, Université de
Montréal, Montréal, QC, Canada.
#2539 Poster Board Number.....................................131
PREDICTION OF HEPATOTOXICITY IN
ZEBRAFISH. ​C. Callol, C. Quevedo and A.
Letamendia. Biobide S.L., San Sebastian, Spain.
Sponsor: S. Tripathi.
Thursday
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