Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#1491 Poster Board Number.....................................439
OXIDATIVE STRESS ASSOCIATED
WITH ULTRAFINE MODEL PARTICLE
SYSTEMS CONTAINING CHEMISORBED
ENVIRONMENTALLY PERSISTENT FREE
RADICALS. ​M. A. Kelley 1 , V. Y. Hebert 1 , S.
A. Cormier 2 , B. Dellinger 3 , S. Lomnicki 3 and
T. R. Dugas 1 . 1 Pharmacology, Toxicology, and
Neuroscience, Louisiana State University Health
Sciences Center, Shreveport, LA, 2 Pharmacology
& Experimental Therapeutics, Louisiana State
University Health Sciences Center, New Orleans, LA
and 3 Chemistry, Louisiana State University, Baton
Rouge, LA.
#1492 Poster Board Number.....................................440
IDENTIFICATION OF SYSTEMIC
MARKERS FROM A PULMONARY CARBON
NANOTUBE EXPOSURE. ​T. Hulderman, A. L.
Liston, R. Salmen-Muniz, S. H. Young, P. C. Zeidler-
Erdely, V. Castranova, P. P. Simeonova and A.
Erdely. NIOSH, Morgantown, WV.
#1493 Poster Board Number.....................................441
IN VITRO VASCULAR TOXICITY OF METAL
OXIDE NANOPARTICLES. ​M. Odegaard and K.
Dreher. Environmental Public Health Division, U.S.
EPA, Research Triangle Park, NC.
#1494 Poster Board Number.....................................442
ACUTE PHASE PROTEINS AS
BIOMARKERS FOR PREDICTING
THE EXPOSURE AND SAFETY OF
NANOMATERIALS. ​Y. Yoshioka 1,2,3 , K.
Higashisaka 1,3 , K. Yamashita 1,3 , M. Fujimura 1,3 , Y.
Morishita 1,3 , P. Huiyan 1,3 , T. Ogura 1,3 , H. Nabeshi 1,3 ,
K. Nagano 3 , Y. Abe 3 , H. Kamada 2,3 , S. Tsunoda 2,3,4 ,
N. Itoh 1,3 , T. Yoshikawa 1,3 and Y. Tsutsumi 1,2,3 .
1
Department of Toxicology and Safety Science,
Graduate School of Pharmaceutical Sciences,
Osaka University, Osaka, Japan, 2 The Center for
Advanced Medical Engineering and Informatics,
Osaka University, Osaka, Japan, 3 Laboratory of
Biopharmaceutical Research, National Institute
of Biomedical Innovation, Osaka, Japan and
4
Department of Biomedical Innovation, Graduate
School of Pharmaceutical Sciences, Osaka
University, Osaka, Japan.
#1495 Poster Board Number.....................................443
TOLL-LIKE RECEPTOR 4 IS INVOLVED IN
THE CEREBROVASCULAR TOXICITY OF
PCB153 BOUND TO NANOPARTICLES. ​B.
Zhang 1,2 , L. Chen 2 , B. Hennig 1,3 and M. Toborek 1,2 .
1
Graduate Center for Nutritional Sciences, University
of Kentucky, Lexington, KY, 2 Department of
Neurosurgery, University of Kentucky, Lexington,
KY and 3 College of Agriculture, University of
Kentucky, Lexington, KY.
#1496 Poster Board Number.....................................444
ASSESSMENT OF PULMONARY TOXICITY
IN MICE AFTER INHALATION EXPOSURE
TO ZINC OXIDE. ​A. Adamcakova-Dodd 1 ,
J. Kim 2 , S. U. Vorrink 2 , L. V. Stebounova 3 , P. T.
O’Shaughnessy 1 , V. H. Grassian 3,2 and P. S. Thorne 1,2 .
1
Occupational and Environmental Health, University
of Iowa, Iowa City, IA, 2 Interdisciplinary Graduate
Program in Human Toxicology, University of Iowa,
Iowa City, IA and 3 Chemistry, University of Iowa,
Iowa City, IA.
Abstract #
Tuesday Afternoon, March 8
1:00 PM to 4:30 PM
Exhibit Hall
Poster Session: Drug Allergy, Pseudoallergy, IDRH, and
Autoimmunity
Chairperson(s): Raymond Pieters, Utrecht University, Utrecht,
Netherlands.
Displayed: 1:00 PM–4:30 PM
Author Attended: 2:45 PM–4:30 PM
#1497 Poster Board Number.....................................501
DEVELOPMENT OF A MOUSE MODEL FOR
PREDICTING DRUG HYPERSENSITIVITY
REACTIONS. ​A. Hudson, S. H. Cole, T. T.
Kawabata and J. Whritenour. Immunotoxicology,
Pfizer Global R&D, Groton, CT.
#1498 Poster Board Number.....................................502
HLA-SPECIFIC T-CELL ACTIVATION
AS AN UNDERLYING CAUSE OF DRUG-
INDUCED HYPERSENSITIVITY. ​J. M.
Goodwin 1 , T. Kawabata 2 and M. T. Pletcher 1 .
1
Compound Safety Prediction, Pfizer, Groton, CT
and 2 Immunotoxicology CoE, Pfizer, Groton, CT.
#1499 Poster Board Number.....................................503
EARLY CHANGES IN AROMATIC AMINE-
INDUCED IDIOSYNCRATIC DRUG
REACTIONS. ​W. Ng and J. Uetrecht. Pharmacy,
University of Toronto, Toronto, ON, Canada.
#1500 Poster Board Number.....................................504
THE USE OF MAST CELLS DERIVED FROM
HUMAN CD34+ HEMATOPOIETIC STEM
CELLS AS A TOOL FOR PREDICTING
PSEUDOALLERGIC DRUG REACTIONS. ​J.
Whritenour 1 , C. Homiski 1 , K. Haskell 2 , M. Thiede 2
and T. T. Kawabata 1 . 1 Immunotoxicology CoE, Drug
Safety Research and Development, Pfizer, Inc.,
Groton, CT and 2 Genetically Modified Mice CoE,
Pfizer, Inc., Groton, CT.
#1501 Poster Board Number.....................................505
EFFECT OF RETINOIC ACID ON
NEVIRAPINE-INDUCED SKIN RASH AND
THE INVOLVEMENT OF TH17 CELLS. ​X.
Chen and J. P. Uetrecht. Faculty of Pharmacy,
University of Toronto, Toronto, ON, Canada.
#1502 Poster Board Number.....................................506
IMMUNOLOGICAL ASPECTS OF AN
ANIMAL MODEL OF AMODIAQUINE-
INDUCED LIVER TOXICITY. ​J. Li 1 , H.
C. Workman 2 , P. Cai 3 , G. Kourteva 4 , H. Hilton 4 ,
H. Haggerty 1 , D. Moore 2 and J. Uetrecht 3,5 .
1
Immunotoxicology, Bristol-Myers Squibb Company,
New Brunswick, NJ, 2 Nonclinical Safety, F.
Hoffmann-La Roche Inc., Nutley, NJ, 3 Pharmacy,
University of Toronto, Toronto, ON, Canada, 4 TRS-
RNA Biomarker Technology, F. Hoffmann-La
Roche Inc., Nutley, NJ and 5 Medicine, University of
Toronto, Toronto, ON, Canada.
Tuesday
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