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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #758 Poster Board Number.....................................821 ALUMINUM CITRATE AND COM: MECHANISMS FOR DECREASED RENAL INJURY IN A RAT MODEL OF ETHYLENE GLYCOL POISONING. L. M. Besenhofer, M. C. McLaren and K. E. McMartin. Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA. #759 Poster Board Number.....................................822 SUB-CHRONIC ETHANOL EXPOSURE INDUCES ACUTE RENAL INJURY AND FIBROSIS IN RATS. C. Latchoumycandane 1 , J. Liu 1 , L. E. Nagy 2 , A. E. Feldstein 1 and T. M. McIntyre 1 . 1 Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH and 2 Pathobiology and Gastroenterology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. #760 Poster Board Number.....................................823 BODY ADIPOSITY AND DIETARY FATTY ACIDS INDUCE CYTOKINE EXPRESSION AND ACTIVATION OF TUMOR PROMOTING PATHWAYS IN THE RAT KIDNEY. A. Bort 1,2 , G. Ananthakrishnan 1 , D. Perez-Tilve 1 , D. R. Dietrich 2 , M. H. Tschöp 1 , P. T. Pfluger 1 and K. Stemmer 1,2 . 1 Department of Internal Medicine, University of Cincinnati, Cincinnati, OH and 2 Human and Environmental Toxicology, University of Konstanz, Konstanz, Germany. #761 Poster Board Number.....................................824 TRANSPORT OF MERCURIC SPECIES IN RABBIT RENAL BRUSH-BORDER MEMBRANE VESICLES. C. Bridges, L. Joshee and R. K. Zalups. Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA. #762 Poster Board Number.....................................825 KIDNEY PROXIMAL TUBULE-ON-A-CHIP FOR DRUG TRANSPORTER STUDIES AND NEPHROTOXICITY ASSESSMENT. K. Jang 1,2 , D. Huh 1,3 , G. A. Hamilton 1 , A. Bahinski 1 , K. Suh 2 and D. E. Ingber 1,3,4 . 1 Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 2 Interdisciplinary Program in Nano-Science and Technology, Seoul National University, Seoul, Republic of Korea, 3 Vascular Biology Program, Departments of Pathology and Surgery, Children’s Hospital, Boston, MA and 4 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA. #763 Poster Board Number.....................................826 ATTENUATION OF OCHRATOXIN A TOXICITY BY INHIBITION OF ORGANIC ANION TRANSPORT. A. Sarma and S. M. Ford. Toxicology Program, St. Johns University, Queens, NY. #764 Poster Board Number.....................................827 EXPRESSION OF THE ZINC/CADMIUM TRANSPORTER, SCL39A8 (ZIP8), IN NORMAL AND TRANSFORMED CELLS OF THE PROSTATE AND BLADDER, AND IN RENAL CORTICAL TISSUE AND DERIVED CELL CULTURE. A. Ajjimaporn, S. H. Garrett, S. Somji, X. Zhou, S. Satarug, M. Sens and D. A. Sens. Pathology, University of North Dakota, Grand Forks, ND. #765 Poster Board Number.....................................828 FIBRINOGEN IS SYNTHESIZED BY THE KIDNEY AND MODULATES TISSUE REPAIR FOLLOWING RENAL INJURY. A. Krishnamoorthy 1 , A. K. Ajay 1 , D. Hoffmann 1 , T. Kim 2 , S. Selvakumar 1 , V. Ramirez 1 , N. Bobadilla 3 , P. Park 2 and V. S. Vaidya 1 . 1 Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2 Center for Biomedical Informatics, Harvard Medical School, Boston, MA and 3 National Autonomous University of Mexico, Mexico City, Mexico. #766 Poster Board Number.....................................829 ETHANOL(ETOH)EXPOSURE IN VIVO POTENTIATES DICLOFENAC(DCLF)- INDUCED NEPHROTOXICITY BY DESTABILIZING GENOMIC INTEGRITY AND PRO- AND ANTIAPOPTOTIC GENES. S. D. Pravasi, S. N. Desai and S. D. Ray. Molecular Toxicology Labs, Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacology & Health Sciences, Brooklyn, NY. #767 Poster Board Number.....................................830 DIVERGENT ASSOCIATIONS OF BLOOD AND URINE CADMIUM LEVELS WITH KIDNEY FUNCTION. V. Weaver 1,2 , M. Tellez- Plaza 1 , A. Navas-Acien 1 , B. Jaar 1,2 , J. Fadrowski 2 , P. Muntner 4 , E. Silbergeld 1 and E. Guallar 1,2,3 . 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2 Johns Hopkins University School of Medicine, Baltimore, MD, 3 Centro Nacional de Investigaciones Cardiovasculares School of Medicine, Madrid, Spain and 4 University of Alabama, Birmingham, AL. #768 Poster Board Number.....................................831 PARADOXICAL ASSOCIATIONS OF URINE CADMIUM WITH SERUM CREATININE BUT NOT CYSTATIN-C-BASED eGFR. J. Fadrowski 1 , N. Kim 3 , B. Jaar 1,2 , J. Spector 4 , P. Parsons 5 , A. Steuerwald 5 , A. Todd 6 , D. Simon 7 , B. Lee 3 , B. Schwartz 1,2 and V. Weaver 1,2 . 1 Johns Hopkins University School of Medicine, Baltimore, MD, 2 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 3 SoonChunHyang University, Asan, Republic of Korea, 4 University of Washington, Seattle, WA, 5 New York State Department of Health, Albany, NY, 6 Mount Sinai School of Medicine, New York and 7 Biostatistical Consulting, Cincinnati, OH. #769 Poster Board Number.....................................832 TISSUE DEPOSIT AND TOXIC MECHANISM OF CADMIUM IN THE KIDNEY OF FE-DEPLETED RATS. J. Park 1 , D. Kim 1 , H. Bae 1 , T. Lee 2 and B. Choi 1 . 1 Preventive Medicine, Chung-Ang University, Seoul, Republic of Korea and 2 Pathology, Chung-Ang University, Seoul, Republic of Korea. 180 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #770 Poster Board Number.....................................833 CADMIUM CAUSES OVER- ACCUMULATION OF P53 THROUGH THE SUPPRESSION OF GENE EXPRESSION OF UBE2D FAMILY IN RAT PROXIMAL TUBULE CELLS. M. Tokumoto 1,2 , Y. Fujiwara 2 , T. Hasegawa 3 , Y. Seko 3 , H. Nagase 1 and M. Satoh 2 . 1 Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan, 2 Laboratory of Pharmaceutical Health Science, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan and 3 Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences, Fujiyoshida, Japan. #771 Poster Board Number.....................................834 CHANGES TO CONNEXIN EXPRESSION IN METALLOTHIONEIN-3 POSITIVE AND NEGATIVE HUMAN PROXIMAL TUBULE CELLS AFTER CADMIUM TREATMENT. L. C. Burgess, T. E. Bhobho, J. R. Murray and M. C. McCoy. Natural Sciences, Dickinson State University, Dickinson, ND. #772 Poster Board Number.....................................835 STATISTICAL ANALYSIS OF LONGITUDINAL GENE EXPRESSION PROFILES IN HUMAN PROXIMAL TUBULE CELLS EXPOSED TO CADMIUM. S. H. Garrett, K. Clarke, D. A. Sens, S. Somji, M. Sens and K. Zhang. Pathology, University of North Dakota, Grand Forks, ND. #773 Poster Board Number.....................................836 ASSOCIATIONS OF MULTIPLE METALS WITH KIDNEY OUTCOMES IN LEAD WORKERS. R. L. Shelley 1 , N. Kim 2 , P. J. Parsons 3 , J. Agnew 1 , A. J. Steuerwald 3 , B. G. Jaar 1 , B. Lee 2 , B. S. Schwartz 1 , G. Matanoski 1 , A. C. Todd 4 , D. Simon 5 and V. Weaver 1 . 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2 SoonChunHyang University, Asan, Republic of Korea, 3 New York State Department of Health, Albany, NY, 4 Mount Sinai School of Medicine, New York, NY and 5 Biostatistical Consulting, Cincinnati, OH. #774 Poster Board Number.....................................837 GENDER DIFFERENCES IN THE MOLECULAR MECHANISMS OF BROMATE INDUCED NEPHROTOXICITY IN F344 RATS. N. Kolisetty 1 , D. A. Delker 2 , C. Nelson 2 , S. Muralidhara 1 , R. J. Bull 3 , O. Quinones 4 , G. Zhongxian 5 , S. Snyder 4 , J. Cotruvo 6 , J. W. Fisher 7 , C. Ong 8 and B. S. Cummings 1 . 1 University of Georgia, Athens, GA, 2 University of Utah, Salt Lake City, UT, 3 Mo Bull Consulting, Richland, WA, 4 Water Quality Research and Development, Henderson, NV, 5 Center for Advanced Water Technology, Singapore, Singapore, 6 Joseph Cotruvo & Assoc., LLC, Washington, D.C., 7 University of Georgia, Athens, GA and 8 National University of Singapore, Singapore, Singapore. Abstract # Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Novel Approaches to Preclinical Safety Assessment: Bridging the Gap between Discovery and the Clinic through Translational Toxicology Poster Session: Pharmaceutical Safety Assessment: Therapeutic Agents Chairperson(s): Anne Gilson, Forest Research Institute, Jersey City, NJ. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #775 Poster Board Number.....................................901 NKTR-181, A NOVEL POLYMER CONJUGATED OPIOID AGONIST, DEMONSTRATES REDUCED TOXICITY AND CNS SIDE EFFECTS RELATIVE TO OXYCODONE. E. Tonkin, S. Wong, A. Odinecs and T. D. Sweeney. Nektar Therapeutics, San Carlos, CA. #776 Poster Board Number.....................................902 RELATIVE TOXICITY ANALYSIS OF DL11F, A HER3, AND EGFR DUAL ACTION ANTIBODY, AND CETUXIMAB IN CYNOMOLGUS MONKEYS. R. Prell 1 , D. Danilenko 1 , C. Wang 1 , A. Kamath 1 , G. Schaefer 1 , P. Allen 2 , J. Roberts 2 and W. Halpern 1 . 1 Genentech, South San Francisco, CA and 2 Valley Biosystems, West Sacramento, CA. #777 Poster Board Number.....................................903 NONCLINICAL CARCINOGENICITY ASSESSMENT OF PRASUGREL. L. A. Buckley 2 , A. Sanbuissho 1 , J. J. Starling 2 , M. Knadler 2 and J. A. Jakubowski 2 . 1 Daiichi Sankyo Co., Ltd., Tokyo, Japan and 2 Eli Lilly & Co., Indianapolis, IN. #778 Poster Board Number.....................................904 OFF-TARGET PLATELET ACTIVATION IN MACAQUES BY A THERAPEUTIC MONOCLONAL ANTIBODY. M. J. Santostefano 1 , N. E. Everds 2 , H. M. Vargas 3 , M. Fort 4 , P. Narayanan 4 , D. Tran 2 , W. Pan 5 , J. Kirchner 6 , C. Vissinga 6 and G. S. Elliott 7 . 1 CBSS - Toxicology, Amgen, Seattle, WA, 2 CBSS - Pathology, Amgen, Seattle, WA, 3 CBSS - Investigative Toxicology, Amgen, Thousand Oaks, CA, 4 CBSS - Investigative Toxicology, Amgen, Seattle, WA, 5 Pharmacokinetics and Drug Metabolism, Amgen, Seattle, WA, 6 Inflammation Research, Amgen, Seattle, WA and 7 Clinical Pathology, Charles River Laboratories, Reno, NV. #779 Poster Board Number.....................................905 CINACALCET HCL: 6-MONTH ORAL TOXICITY STUDY IN JUVENILE BEAGLE DOGS. K. Black 1 , C. Dean 1 , N. Everds 1 , E. Lesage 2 and M. Loomis 1 . 1 Amgen Inc., Thousand Oaks, CA and 2 Charles River Laboratories Preclinical Services, Senneville, QC, Canada. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 181
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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