Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #449 Poster Board Number.....................................134 THE ALPHA MUPA MICE, A MODEL OF CALORIC RESTRICTION, ARE MORE SUSCEPTIBLE TO ACETAMINOPHEN HEPATOTOXICITY. Z. Fu 1 , Y. Zhang 1 , R. Miskin 2 and C. D. Klaassen 1 . 1 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS and 2 Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel. #450 Poster Board Number.....................................135 ACTIVATION OF CASPASES DURING ACETAMINOPHEN TOXICITY IS A STRAIN DEPENDENT PHENOMENON. H. Jaeschke, M. Koerner and C. D. Williams. University of Kansas Medical Center, Kansas City, KS. #451 Poster Board Number.....................................136 INHIBITION OF THE MITOCHONDRIAL MEMBRANE PERMEABILITY TRANSITION PORE PROTECTS AGAINST ACETAMINOPHEN-INDUCED MITOCHONDRIAL OXIDANT STRESS AND LIVER INJURY IN VIVO. A. Ramachandran 1 , M. Lebofsky 1 , C. Baines 2 , S. A. Weinman 1 , J. J. Lemasters 3 and H. Jaeschke 1 . 1 Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, 2 University of Missouri, Columbia, MO and 3 Medical University of South Carolina, Charleston, SC. #452 Poster Board Number.....................................137 ROLE OF THE NALP3 INFLAMMASOME IN NEUTROPHIL ACTIVATION AND CELL INJURY DURING ACETAMINOPHEN- INDUCED HEPATOTOXICITY. C. D. Williams 1 , P. J. Shaw 2 and H. Jaeschke 1 . 1 University of Kansas Medical Center, Kansas City, KS and 2 New York University, New York, NY. #453 Poster Board Number.....................................138 ACETAMINOPHEN HEPATOTOXICITY IN HUMANS: MITOCHONDRIAL INJURY AND DNA FRAGMENTATION IN OVERDOSE PATIENTS. M. R. McGill 1 , M. R. Sharpe 2 , C. Williams 1 , M. Taha 2 and H. Jaeschke 1 . 1 Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS and 2 Internal Medicine, University of Kansas Medical Center, Kansas City, KS. #454 Poster Board Number.....................................139 KAVA EXTRACT, AN HERBAL ALTERNATIVE FOR ANXIETY RELIEF, POTENTIATES ACETAMINOPHEN- INDUCED CYTOTOXICITY IN RAT HEPATIC CELLS. X. Yang and W. F. Salminen. Division of Systems Biology, U.S. FDA, NCTR, Jefferson, AR. #455 Poster Board Number.....................................140 HEPATIC ENDOTHELIAL CELLS REGULATE LIVER CELL REPAIR FOLLOWING ACETAMINOPHEN INTOXICATION. Y. Liu, C. R. Gardner, M. Francis, J. D. Laskin and D. L. Laskin. Pharmacology & Toxicology, Rutgers University, Piscataway, NJ. #456 Poster Board Number.....................................141 NEGATIVE REGULATION OF CLASSICAL MACROPHAGE ACTIVATION BY THE STK RECEPTOR DURING ACETAMINOPHEN- INDUCED HEPATOTOXICITY. C. R. Gardner 1 , Y. Liu 1 , P. A. Hankey 2 , J. D. Laskin 3 and D. L. Laskin 1 . 1 Rutgers University, Piscataway, NJ, 2 Pennsylvania State University, University Park, PA and 3 UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. #457 Poster Board Number.....................................142 ROLE OF MACROPHAGE-DERIVED GALECTIN-3 IN ACETAMINOPHEN- INDUCED HEPATOTOXICITY. A. Dragomir 1 , R. Sun 1 , J. D. Laskin 2 and D. L. Laskin 1 . 1 Pharmacology and Toxicology, Rutgers University, Piscataway, NJ and 2 Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ. #458 Poster Board Number.....................................143 TARGETING OF THIOREDOXIN REDUCTASE BY THE ACETAMINOPHEN METABOLITE N-ACETYL-P- BENZOQUINONE IMINE. Y. Jan 1 , D. E. Heck 2 , D. L. Laskin 3 , Y. Liu 3 , A. Dragomir 3 and J. D. Laskin 1 . 1 Environmental & Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 2 Environmental Health, New York Medical College, Valhalla, NY and 3 Pharmacology & Toxicology, Rutgers University, Piscataway, NJ. #459 Poster Board Number.....................................144 TRIFLUOPERAZINE MEDIATED HEPATOPROTECTION AND REDUCTION OF HIF-1α IN ACETAMINOPHEN MEDIATED TOXICITY IN MICE. S. Chaudhuri 1 , S. S. McCullough 1 , A. Brown 1 , J. A. Hinson 2 and L. P. James 1,2 . 1 Pediatrics/ Clinical Pharmacology, Arkansas Childrens Hospital Research Institute, Little Rock, AR and 2 Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR. #460 Poster Board Number.....................................145 SULFORAPHANE PREVENTS ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE. R. Schmidt 1,2 , K. C. Falkner 2,3 , J. Beier 1,2 and G. Arteel 1,2 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY, 2 Alcohol Research Center, University of Louisville, Louisville, KY and 3 Medicine, University of Louisville, Louisville, KY. Sponsor: C. States. #461 Poster Board Number.....................................146 ACETAMINOPHEN (APAP) AND S-ADENOSYL-L-METHIONINE (SAME) EFFECTS ON OXIDATIVE STRESS ENZYMES: ATTENUATION BY SAME. J. Brown, J. G. Ball, T. Ahmad and M. Valentovic. Pharmacology, Physiology, and Toxicology, Marshall University School of Medicine, Huntington, WV. #462 Poster Board Number.....................................147 NERVE GROWTH FACTOR (NGF) IN MOUSE LIVER HAS AN AUTOCRINE ACTIVITY AND ITS TRANSCRIPTION IS MODULATED BY BSO, ACETAMINOPHEN, AND ARSENIC. C. Valdovinos and M. E. Gonsebatt. Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico. 156 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #463 Poster Board Number.....................................148 URINE PROTEOMIC PROFILING FOR BIOMARKERS OF ACETAMINOPHEN- INDUCED ACUTE LIVER INJURY IN MICE AND HUMANS. R. P. van Swelm 1 , C. M. Laarakkers 2 , R. Masereeuw 1 and F. G. Russel 1 . 1 Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands and 2 Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. Sponsor: R. Pieters. Monday Afternoon, March 7 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Risk Assessment: Computational Approaches, Analyses, and Applications Chairperson(s): MaryJane Selgrade, ICF International, Durham, NC, and Lynne Haber, Toxicology Excellence for Risk Assessment (TERA), Cincinnati, OH. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #464 Poster Board Number.....................................207 DEVELOPMENT OF A MECHANISTIC SAR MODEL FOR THE DETECTION OF PHOTOTOXIC CHEMICALS AND USE IN AN INTEGRATED TESTING STRATEGY. S. Ringeissen 1 , L. Marrot 1 , R. R. Note 1 , A. Labarussiat 1 , S. Imbert 1 , M. Todorov 2 , O. Mekenyan 2 and J. Meunier 1 . 1 L’Oreal, Aulnay Sous Bois, France and 2 Laboratory of Mathematical Chemistry, Bourgas, Bulgaria. Sponsor: H. Toutain. #465 Poster Board Number.....................................208 QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP MODELING OF SKIN SENSITIZERS TESTED IN LOCAL LYMPH NODE ASSAY. D. Pu 1 , H. Zhu 1 , G. Zhao 1 , J. Strickland 2 , E. Salicru 2 and A. Tropsha 1 . 1 University of North Carolina, Chapel Hill, NC and 2 ILS, Research Triangle Park, NC. #466 Poster Board Number.....................................209 3D ORGANOTYPIC EPIOCULAR EYE IRRITATION TEST (EIT) RESULTS – USE OF ALTERNATIVE TISSUE CULTURE INSERTS. M. Klausner, Y. Kaluzhny, P. J. Hayden, L. d’Argembeau-Thornton and H. Kandarova. MatTek Corp, Ashland, MA. #467 Poster Board Number.....................................210 GUIDING FORMULA DEVELOPMENT UTILIZING THE CLINICAL CUMULATIVE IRRITATION CLINICAL TESTING WHEN INGREDIENTS INTERFERE WITH IN VITRO IRRITATION ASSAY. D. Orak, P. Kazmi, V. Srinivasan and T. A. Re. Safety Evaluation, L’Oreal USA, Clark, NJ. Abstract # #468 Poster Board Number.....................................211 A WEIGHT OF EVIDENCE APPROACH TO IMPROVING SAR PREDICTION OF ALLERGIC CONTACT DERMATITIS. C. Seaman 1 , A. Quayson 2 , M. J. Olson 3 and F. Guerriero 4 . 1 HS&P, GlaxoSmithkline, Ware, Herts, United Kingdom, 2 School of Biosciences, University of Birmingham, Birmingham, West Midlands, United Kingdom, 3 HS&P, GlaxoSmithKline, Research Triangle Park, NC and 4 HS&P, GlaxoSmithKline, Philadelphia, PA. #469 Poster Board Number.....................................212 A MECHANISTIC RATIONALE FOR THE PREDICTION OF SKIN IRRITANCY EFFECTS IMPLEMENTED IN A WORKFLOW PROCESS. C. Yang 2 , S. Ringeissen 1 , J. F. Rathman 2,3 , B. Prunier 1 , R. Note 1 and J. Meunier 1 . 1 L’Oreal Recherche, Aulany-sous- Bois, 93600, France, 2 Altamira LLC, Columbus, OH and 3 The Ohio State University, Columbus, OH. #470 Poster Board Number.....................................213 DECISION TREES FOR EVALUATING SKIN AND RESPIRATORY SENSITIZING POTENTIAL OF CHEMICALS FOR REACH. M. Selgrade 1 , K. Sullivan 1 , R. Boyles 1 , E. Dederick 1 , T. Serex 2 and S. Loveless 2 . 1 ICF International, Fairfax, VA and 2 DuPont Haskell Global Centers for Health & Environmental Sciences, Newark, DE. #471 Poster Board Number.....................................214 DEVELOPMENT OF A MICROBIAL RISK ASSESSMENT GUIDELINE. Microbial Risk Assessment Guideline Workgroup. The Federal Interagency. USDA, U.S. EPA, DHHS and other Federal Agencies, Washington, D.C. Sponsor: A. Kadry. #472 Poster Board Number.....................................215 PRELIMINARY SENSITIVITY EVALUATION FOR CUMULATIVE IMPACTS ANALYSIS. G. V. Alexeeff, J. Faust, L. Meehan and L. Zeise. OEHHA, California/U.S. EPA, Oakland, CA. #473 Poster Board Number.....................................216 CATEGORICAL REGRESSION: STRENGTHS, WEAKNESSES, AND APPLICATIONS. L. T. Haber 1 , R. Danzeisen 2 and J. S. Gift 3 . 1 Toxicology Excellence for Risk Assessment (TERA), Cincinnati, OH, 2 International Copper Association, New York, NY and 3 U.S. EPA ORD NCEA, Research Triangle Park, NC. #474 Poster Board Number.....................................217 USE OF POWER LAW MODELING TO ESTIMATE LOW DOSE HUMAN RELATIVE POTENCIES OF DIOXIN- LIKE COMPOUNDS (DLCS). T. B. Starr 1 , E. A. Carlson 3 , C. H. Sutter 2 , T. R. Sutter 2 and J. B. Silkworth 3 . 1 TBS Associates, Raleigh, NC, 2 University of Memphis, Memphis, TN and 3 General Electric, Niskayuna, NY. #475 Poster Board Number.....................................218 NON-THRESHOLD BIOLOGICAL PROCESSES AND THE ASSUMPTION OF LOW-DOSE LINEARITY: CONSIDERATION OF RECEPTOR-MEDIATED EVENTS IN RISK ASSESSMENT. P. D. White, M. A. Spassova, R. P. Subramaniam and L. Kopylev. U.S. EPA, Washington, D.C. Sponsor: S. Vulimiri. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 157
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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SOT Presidents 1961-2011 1966 1967
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Toxicological Sciences The Official
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Society of Toxicology 2011 ToxExpo
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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