Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Morning, March 8 6:30 AM to 7:50 AM Room 147 Integration of Toxicological and Epidemiological Evidence to Understand Human Risk Informational Session: Emerging Science for Environmental Health Decisions: Tools, Strategies, and Evidence Chairperson(s): William Farland, Colorado State University, Fort Collins, CO, and John Balbus, NIEHS, Bethesda, MD. Sponsor: Risk Assessment Specialty Section Endorsed by: Association of Scientist of Indian Origin Special Interest Group Biological Modeling Specialty Section The last year was very productive for the National Research Council’s (NRC) Standing Committee on Emerging Science for Environmental Health Decisions, sponsored by the National Institutes of Environmental Health Science. A number of timely, topical sessions were held that included SOT members that were of special relevance to toxicology, risk assessment, and public health. These topics were designed to extend discussion contained in two 2007 NRC reports—Toxicity Testing in the 21st Century: A Vision and a Strategy and Application of Toxicogenomics Technologies to Predictive Toxicology and Risk Assessment. These sessions brought together government, industry, environmental groups, and the academic community to discuss emerging scientific concepts and advances and their potential implications for environmental health decisions. Specifically, these sessions have explored emerging tools and technologies for epigenetics, computational toxicology, stem cell models, and exposome research and their potential roles in identifying, quantifying, and mitigating environmental impacts on human health. In follow up to these dynamic sessions we will highlight many aspects of this important topic. Our panel of experts will address what was learned linking specifically to the common threads among the sessions, such as bioinformatics and expanding input information for systems approaches to toxicology. In closing, we’ll synthesize how to best integrate data across these emerging and evolving areas of research and explore potential next steps for using such data and insights in environmental health decisions and policy. #883 6:30 EMERGING SCIENCE FOR ENVIRONMENTAL HEALTH DECISIONS: TOOLS, STRATEGIES, AND EVIDENCE. W. H. Farland. Colorado State University, Fort Collins, CO. 6:30 WELCOME AND INTRODUCTION. William H. Farland 6:35 THE EPIGENETICS LINK. Helmut Zarbl 6:50 THE EXPOSOME: EXPLORING THE ENVIRONMENTAL ETIOLOGY OF HUMAN DISEASE. Elaine Cohen Hubal 7:05 STEM CELL MODELS AND ENVIRONMENTAL HEALTH. Tom Gasiewicz 7:20 INTEGRATING EMERGING SCIENCE: COMPUTATIONAL TOXICOLOGY. Ivan Rusyn 7:35 THE PATH TO INCORPORATING EMERGING SCIENCE IN ENVIRONMENTAL HEALTH DECISIONS. Linda Birnbaum Tuesday Morning, March 8 7:00 AM to 7:50 AM Room 201 Leading Edge in Basic Science Award Lecture: Roles of Keap1-Nrf2 in Environmental Response Lecturer: Masayuki Yamamoto, Tohoku University Graduate School of Medicine, Sendai, Japan. Studies of the erythroid gene expression identified the NF-E2 motif and CNC family of transcription factors. As the NF-E2 motif and antioxidant responsive element (ARE) share high-level sequence similarity, a CNC factor Nrf2 was identified as a key transcriptional activator interacting with ARE. Targeted disruption of the Nrf2 gene revealed that Nrf2 is essential for the coordinated induction of cellular defense enzymes. Keap1 was identified as a sensor for xenobiotic and oxidative stresses and a component of ubiquitin E3 ligase. The two-site substrate recognition model proposed for the Keap1-Nrf2 system describes the regulation of nuclear accumulation of Nrf2 by a Keap1-dependent mechanism. Both high-affinity ETGE and low-affinity DLG motifs of the Nrf2 Neh2 domain bind to two Keap1-DC domains of the Keap1 homodimer. This allows correct positioning of the ubiquitintarget lysines within Neh2 for efficient ubiquitination. Oxidative or electrophilic stress modifies multiple reactive cysteines of Keap1, and these modifications lead to alteration of the local conformation, resulting in the dissociation of either lower-affinity DLG motif or an E3 component Cul3 from Keap1. We recently found cancer-related mutations of the Keap1-Nrf2 system. These mutations are activating mutations of Nrf2 and concentrated in the Keap1-Nrf2 interface, strongly supporting the two-site recognition model. Tuesday Morning, March 8 7:00 AM to 8:30 AM Room 103 Regional Chapter Presidents and Officers Meeting If you will be a President or a Vice President of a Regional Chapter in 2011–2012, please make plans to attend the Regional Chapter Presidents and Officers meeting. The agenda for the meeting will include an overview of the SOT Long-Range Plan. SOT Headquarters support services and 50th Anniversary Celebration Events, SAC, and PDA Representatives recruitment and involvement, Regional Chapter funding, RC Communities on ToXchange, RC Governance Group, and discussion of face-to-face summer leadership meeting. Tuesday Morning, March 8 7:00 AM to 8:30 AM Room 142 Speciality Section Graduate Committee Meeting 194 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # Tuesday Morning, March 8 8:00 AM to 9:00 AM Grand Ballroom Keynote Plenary Lecture: Increasing the Prestige of Regulatory Sciences Lecturer: Margaret Hamburg, U.S. FDA, Washington, D.C. Described as “an inspiring public health leader with broad experience in infectious disease, bioterrorism, and health policy” by HHS Secretary Kathleen Sebelius we are delighted to have Dr. Margaret A. Hamburg, the 21st U.S. FDA Commissioner present a keynote plenary lecture at the Society’s 50th Anniversary Annual Meeting. Dr. Hamburg is exceptionally qualified by her training and experience as a medical doctor, scientist, and public health executive. Dr. Hamburg graduated from Harvard Medical School, and completed her residency in internal medicine at what is now New York Presbyterian Hospital-Weill Cornell Medical Center, one of the top-ten hospitals in the nation. She conducted research on neuroscience at Rockefeller University in New York, studied neuropharmacology at the National Institute of Mental Health on the National Institutes of Health campus in Bethesda, Maryland, and later focused on AIDS research as Assistant Director of the National Institute of Allergy and Infectious Diseases. During her career she has been widely praised for her initiatives, decisive leadership, and significant public health measures. As a public health official she is credited with improving services for women and children, a needle-exchange program to reduce the spread of HIV (the AIDS virus), and the initiation the first public health bio-terrorism defense program in the nation. Her most celebrated achievement, however, was curbing the spread of tuberculosis in the 1990s. In 1994, Dr. Hamburg was elected to the membership in the Institute of Medicine, one of the youngest persons to be so honored. Three years later, at the request of President Clinton, she accepted the position of Assistant Secretary for Policy and Evaluation in the U.S. Department of Health and Human Services (HHS). Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 206 Global Air Quality and Human Health Symposium Session: Metabolic Basis of Respiratory Tract Chemical Toxicity Chairperson(s): Laura Van Winkle, University of California Davis, Davis, CA, and Xinxin Ding, New York State Department of Health, Albany, NY. Sponsor: Inhalation and Respiratory Specialty Section Endorsed by: Mechanisms Specialty Section Molecular Biology Specialty Section The respiratory tract, including both the lung and the nasal tissue, has substantial metabolic activity, which can influence the distribution and action of drugs and xenobiotics, either inhaled or ingested. The metabolic enzymes that are active in the respiratory tract include cytochrome P450 monooxygenases, esterases, oxidoreductases, and dehydrogenases. Their distribution and activity can vary greatly with anatomic location, by species, sex and history of prior exposure. Respiratory tract metabolic activity can either enhance, or inhibit, local and systemic chemical toxicity. While this basic principle has been understood and investigated for many years, recent new approaches have allowed more in-Department investigation of Abstract # the mechanisms of toxicity in the respiratory tract following exposure to bioactivated toxicants. Significant advances have been made, with the use of novel animal models, new detection methods, application of site-specific approaches to colocalize toxicity and metabolism, recombinant human enzymes, and modeling, which enhance our understanding of the contributions of xenobiotic metabolism in the respiratory tract to toxicity in humans. Several examples highlighting recent progress in this area will be presented. #884 9:00 METABOLIC BASIS OF RESPIRATORY TRACT CHEMICAL TOXICITY. L. S. Van Winkle 1 and X. Ding 2 . 1 Center for Health and the Environment/Veterinary Medicine, Anatomy, Physiology, and Cell Physiology, University of California Davis, Davis, CA and 2 Division of Environmental Health Sciences, Laboratory of Molecular Toxicology, Wadsworth Center, New York State Department of Health, Albany, NY. 9:00 INTRODUCTION. Laura Van Winkle #885 9:05 ROLE OF CYP2A AND CYP2F ENZYMES IN RESPIRATORY TRACT CHEMICAL TOXICITY – INSIGHTS FROM P450 KNOCKOUT AND HUMANIZED MOUSE MODELS. X. Ding 1,2 . 1 Laboratory of Molecular Toxicology, Wadsworth Center, New York State Department of Health, Albany, NY and 2 School of Public Health, State University of New York at Albany, Albany, NY. #886 9:36 METABOLISM OF INHALED GLUCOCORTICOIDS IN LUNG: SELECTIVE INACTIVATION OF CYP3A5. G. S. Yost. Deptartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT. #887 10:07 SEX DIFFERENCES IN METABOLISM AND TOXICITY IN THE LUNG. L. S. Van Winkle, K. Sutherland, D. Morin, P. Edwards and A. Buckpitt. University of California Davis, Davis, CA. #888 10:38 DEVELOPMENT OF ADDUCTED PEPTIDE BIOMARKERS TO ADDRESS THE CONSEQUENCES OF HUMAN EXPOSURE TO RODENT PULMONARY TOXICANTS. A. Buckpitt, N. Pham, D. Krawiec, D. Morin, W. Jewell and L. Van Winkle. University of California Davis, Davis, CA. #889 11:09 RESPIRATORY TRACT METABOLISM AND INHALATION DOSIMETRY OF VAPORS. J. B. Morris. Toxicology Program, University of Connecticut, Storrs, CT. 11:40 SUMMARY. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 195
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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