Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#128 Poster Board Number.....................................217
SEQUENCE TAGGING REVEALS
UNEXPECTED MODIFICATIONS IN
TOXICOPROTEOMICS. ​S. Dasari 1 , M. C.
Chambers 1 , D. C. Liebler 2 , F. P. Guengerich 2 and
D. L. Tabb 1,2 . 1 Biomedical Informatics, School of
Medicine, Vanderbilt University, Nashville, TN
and 2 Biochemistry, School of Medicine, Vanderbilt
University, Nashville, TN.
#129 Poster Board Number.....................................218
PROTEOMIC PROFILING OF DYNAMIC
CELLULAR RESPONSES TO SILICA
NANOPARTICLES USING STABLE ISOTOPE
AMINO ACID LABELING. ​B. Thrall 1 , B. Webb-
Robertson 2 , K. Burnham 3 , M. H. Littke 1 , N. J. Karin 3 ,
J. Jacobs 3 and K. M. Waters 2 . 1 Cell Biology &
Biochemistry, PNNL, Richland, WA, 2 Computational
Biology & Bioinformatics, PNNL, Richland, WA
and 3 Biological Separations & Mass Spectrometry
Groups, Pacific Northwest National Laboratory,
Richland, WA.
#130 Poster Board Number.....................................219
ENVIRONMENTAL CHEMICALS AND
HUMAN HEALTH: UNCOVERING THE
CONNECTIONS WITH CTD. ​C. Mattingly, C.
G. Murphy, C. A. Saraceni-Richards, S. Mockus,
M. C. Rosenstein, T. C. Wiegers, B. King and A. P.
Davis. Bioinformatics, MDI Biological Laboratory,
Salisbury Cove, ME.
#131 Poster Board Number.....................................220
GENERATING A GENE NETWORKS
ASSOCIATED WITH KOLA ACUMINATA-
BIZZY NUT INDUCE APOPTOSIS. ​R. Ledet
and W. G. Gray. Chemistry, Southern University
A&M College, Baton Rouge, LA.
#132 Poster Board Number.....................................221
VIRTUAL SCREENING OF DIFFERENTIAL
PROTEIN TARGETS FOR TROVAFLOXACIN
AND LEVOFLOXACIN. ​J. Olivero-Verbel,
C. Ortega-Zuñiga and M. Cabarcas-Montalvo.
Environmental and Computational Chemistry
Group, University of Cartagena, Cartagena, Bolivar,
Colombia.
#133 Poster Board Number.....................................222
THE MOUSE GENOME INFORMATICS
DATABASE: INTEGRATING INFORMATION
TO FACILITATE DISCOVERY. ​S. M. Bello, C.
L. Smith, H. Dene, D. L. Burkart, L. L. Washburn,
M. Tomczuk, A. Anagnostopoulos, B. Richards-
Smith, H. Onda, R. P. Babiuk, M. Knowlton, J.
Xu, J. A. Bubier and J. T. Eppig. Mouse Genome
Informatics, The Jackson Laboratory, Bar Harbor,
ME.
#134 Poster Board Number.....................................223
FINDING CLUSTERS OF CHEMICALS
AFFECTING SUB-NETWORKS OF THE
PROTEIN INTERACTOME. ​R. Thomas 1 ,
I. Gerlovina 1 , A. Hubbard 1 , M. North 2 and C.
Vulpe 2 . 1 Biostatistics, University of California,
Berkeley, Berkeley, CA and 2 Nutritional Science
and Toxicology, University of California, Berkeley,
Berkeley, CA.
Abstract #
#135 Poster Board Number.....................................224
A BIOINFORMATICS-BASED PIPELINE
FOR BIOMARKER DISCOVERY UTILIZING
BOTH IN VITRO AND IN VIVO DATA. ​
R. C. Grafström 1,2 , R. Ceder 1 , C. A. Staab 3 , J.
Höög 3 , H. Jörnvall 3 , M. Nees 2 , B. Fadeel and K.
Roberg 4 . 1 Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden, 2 Medical
Biotechnology, VTT Technical Research Centre of
Finland, Turku, Finland, 3 Department of Medical
Biochemistry and Biophysics, Karolinska Institutet,
Stockholm, Sweden and 4 Department of Clinical
and Experimental Medicine, Linköping University,
Linköping, Sweden.
#136 Poster Board Number.....................................225
CHARACTERIZATION OF A QSAR MODEL
FOR PHOSPHOLIPIDOSIS USING A
HIERARCHICAL SCAFFOLD TREE OF
SIGNIFICANT MOLECULAR FEATURES. ​
N. L. Kruhlak 1 , K. Cross 2 and A. M. Orogo 1,3 . 1 U.S.
FDA/CDER/OTR/DAPR, Silver Spring, MD,
2
Leadscope Inc., Columbus, OH and 3 GlobalNet
Services Inc., Rockville, MD. Sponsor: R. Benz.
#137 Poster Board Number.....................................226
IN SILICO PREDICTIVE MODEL FOR
DRUG-INDUCED PHOSPHOLIPIDOSIS
USING BIOEPISTEME SOFTWARE. ​S. S.
Choi, L. G. Valerio and N. Sadrieh. U.S. FDA, Silver
Spring, MD.
#138 Poster Board Number.....................................227
PREDICTION OF DRUG-INDUCED
LIVER INJURY IN HUMANS WITH
TOXICOGENOMICS. ​M. Zhang, Q. Shi, M.
Chen and W. Tong. NCTR, U.S. FDA, Jefferson, AR.
#139 Poster Board Number.....................................228
PREDICTIVE VALUE OF CHEMICAL AND
TOXICOGENOMIC DESCRIPTORS FOR
DRUG-INDUCED HEPATOTOXICITY. ​Y.
Low 1,5 , T. Uehara 1,2 , Y. Minowa 2 , H. Yamada 2 ,
Y. Ohno 3 , T. Urushidani 2,4 , A. Sedykh 5 , D.
Fourches 5 , H. Zhu 5 , I. Rusyn 1 and A. Tropsha 5 .
1
Environmental Sciences & Engineering, University
of North Carolina at Chapel Hill, Chapel Hill, NC,
2
Toxicogenomics Informatics Project, National
Institute of Biomedical Innovation, Osaka, Japan,
3
National Institute of Health Sciences, Tokyo, Japan,
4
Doshisha Women’s College of Liberal Arts, Kyoto,
Japan and 5 Eshelman School of Pharmacy, University
of North Carolina at Chapel Hill, Chapel Hill, NC.
#140 Poster Board Number.....................................229
CLASSIFICATION OF HUMAN
CYTOCHROME 3A4 LIGANDS BY MEANS
OF MOLECULAR DOCKING. ​Y. Tie 1 , B. T.
McPhail 1 , H. Hong 2 , R. D. Beger 2 , B. A. Fowler 1 and
E. Demchuk 1 . 1 Division Toxicology & Environmental
Medicine, ATSDR/CDC, Atlanta, GA and 2 Division
Systems Biology, NCTR/U.S. FDA, Jefferson, AR.
#141 Poster Board Number.....................................230
BUILDING STRUCTURE FEATURE-BASED
MODELS FOR PREDICTING ISOFORM-
SPECIFIC HUMAN CYTOCHROME P450
(HCYP 3A4, 2D6 AND 2C9) INHIBITION
ASSAY RESULTS IN TOXCAST. ​P. Volarath 1 , B.
Bienfait 2 , J. Gasteiger 2 , K. Houck 1 and A. Richard 1 .
1
NCCT, U.S. EPA, Research Triangle Park, NC and
2
Molecular Networks GmbH, Erlangen, Germany.
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