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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Thursday Abstract # Abstract # #2540 Poster Board Number.....................................132 PREDICTION OF DRUG-INDUCED LIVER INJURY WITH HIGH SENSITIVITY AND SPECIFICITY WITH HIGH-CONTENT CELL-BASED IMAGING. R. N. Ghosh, S. J. Hong, B. A. Samson, K. Corkan, M. Pietila, C. Vasudevan and J. R. Haskins. Thermo Fisher Scientific, Pittsburgh, PA. #2541 Poster Board Number.....................................133 GENE EXPRESSION PROFILING OF AN IN VITRO HUMAN SKIN MODEL AFTER PSORALEN PLUS ULTRAVIOLET LIGHT- INDUCED PHOTOTOXICITY. L. F. Pratt 1 , G. L. DeGeorge 1 and M. Cunningham 2 . 1 MB Research Laboratories, Spinnerstown, PA and 2 Nanomics Biosciences, Inc., Cary, NC. #2542 Poster Board Number.....................................134 OXIDATIVE STRESS AND HYPOXIA AS FACTORS IN PHOTOTOXIC DAMAGE TO A RECONSTITUTED HUMAN SKIN MODEL: GENE EXPRESSION PROFILING EVIDENCE. M. Cunningham 2 , L. F. Pratt 1 and G. L. DeGeorge 1 . 1 MB Research Laboratories, Spinnerstown, PA and 2 Nanomics Biosciences, Inc., Cary, NC. Thursday Morning, March 10 8:30 AM to 12:00 NOON East Salon Poster Session: Alternatives to Animal Models in Toxicology Chairperson(s): Robert Landsiedel, BASF SE, Ludwigshafen am Rhein, Germany. Displayed: 8:30 AM–12:00 NOON Author Attended: 10:15 AM–12:00 NOON #2543 Poster Board Number.....................................137 A NEW IN VITRO MODEL FOR IDENTIFYING LIVER SPECIFIC TOXICITY (LST). J. M. McKim, B. Wallace, P. C. Wilga, C. Toole, H. Wagner, A. Swanson and K. Rutherford. CeeTox, Inc., Kalamazoo, MI. #2544 Poster Board Number.....................................138 DEVELOPING AN IN VITRO MODEL TO DETERMINE KIDNEY SPECIFIC TOXICITY (KST). J. F. Pregenzer 1 , K. Leach 2 , B. Feng 3 , B. Wallace 1 , D. Keller 1 , J. Willoughby 1 and J. M. McKim 1 . 1 CeeTox, Inc., Kalamazoo, MI, 2 Compound Safety Prediction, Pfizer Global Research and Development, Groton, CT and 3 Pharmacokinetics and Drug Metabolism, Pfizer Global Research and Development, Groton, CT. #2545 Poster Board Number.....................................139 IN VITRO ASSESSMENT OF EYE TOLERANCE USING THE SKINETHIC HCE TEST METHOD APPLIED TO INGREDIENTS USED IN COSMETICS. M. H. Grandidier, N. Alépée, S. Blond, J. Eilstein, D. Duché, J. Cotovio and J. R. Meunier. L’Oréal, Aulnay sous Bois, France. Sponsor: H. Toutain. #2546 Poster Board Number.....................................140 USING FUNDULUS HETEROCLITUS TO STUDY BENZO(A)PYRENE EFFECTS ON THE HYPOTHALAMUS-PITUITARY- GONAD (HPG) AXIS. F. T. Booc 1 , C. Thornton 1 , D. MacLatchy 2 , A. Lister 2 and K. L. Willett 1 . 1 Pharmacology, University of Mississippi, University, MS and 2 Biology, Wilfrid Laurier University, Waterloo, ON, Canada. #2547 Poster Board Number.....................................141 PORCINE ADRENAL CORTEX MICROSOMES AS IN VITRO ALTERNATIVE ASSAY FOR SCREENING ON SEX STEROIDOGENESIS TOXICITY. M. Roelofs 1,2 , M. van den Berg 1 , A. H. Piersma 2,1 and M. B. van Duursen 1 . 1 Endocrine Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands and 2 National Institute for Public Health and the Environment, Bilthoven, Netherlands. #2548 Poster Board Number.....................................142 EARLY DISRUPTION OF ANGIOGENESIS- RELATED GENES BY METHYL TERT-BUTYL ETHER (MTBE) LEADS TO VASCULAR SPECIFIC LESIONS IN THE ZEBRAFISH (DANIO RERIO). J. A. Bonventre, L. A. White and K. R. Cooper. Joint Graduate Program in Toxicology, Rutgers University/UMDNJ, Piscataway, NJ. #2549 Poster Board Number.....................................143 EFFECT OF TRIAZINES ON TESTOSTERONE BIOSYNTHESIS IN BLTK1 MURINE LEYDIG TUMOR CELLS. A. L. Forgacs 1 , Q. Ding 1 , I. T. Huhtaniemi 2 , N. A. Rahman 2 and T. R. Zacharewski 1 . 1 Michigan State University, East Lansing, MI and 2 University of Turku, Turku, Finland. #2550 Poster Board Number.....................................144 IMPROVEMENTS AND LIMITATIONS OF THE BOVINE CORNEAL OPACITY AND PERMEABILITY TEST (BCOP, OECD TEST GUIDELINE 437) IN ROUTINE TESTING FOR SEVERE OCULAR IRRITANTS. H. Raabe 3 , A. Schrage 1 , R. Curren 3 , K. Norman 3 , S. N. Kolle 2 , M. Rey-Moreno 2 , B. van Ravenzwaay 2 and R. Landsiedel 2 . 1 Product Safety, BASF SE, Ludwigshafen, Germany, 2 Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany and 3 Institute for In Vitro Sciences, Inc., Gaithersburg, MD. #2551 Poster Board Number.....................................145 ECVAM PREVALIDATION STUDY ON SKIN SENSITISATION ALTERNATIVES: UPDATE ON PROGRESS. A. Angers-Loustau 1 , D. Basketter 2 , P. Aeby 3 , S. Aiba 4 , N. Alépée 8 , T. Ashikaga 5 , T. Cole 1 , A. Compagnoni 1 , G. Gerberick 6 , S. Hoffmann 7 , J. Ovigne 8 , J. Richmond 9 , H. Sakaguchi 10 and S. Casati 1 . 1 European Commission (Joint Research Centre), Ispra, Italy, 2 DABMEB Consultancy Ltd., Sharnbrook, Bedfordshire, United Kingdom, 3 Colipa, Skin Tolerance Task Force, Brussels, Belgium, 4 Tohoku University Graduate School of Medicine, Sendai, Japan, 5 Shiseido Quality Assessment Center, Yokohama, Japan, 6 Procter & Gamble, Cincinnati, OH, 7 Seh Consulting & Services, Koln, Germany, 8 L’Oréal Research, Aulnay-sous-Bois, France, 9 Home Office, Dundee, United Kingdom and 10 Kao Corporation Safety Science Research Laboratories, Tochigi, Japan. 344 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #2552 Poster Board Number.....................................146 LEYDIG CELLS RESPONSES TO STIMULATION WITH LUTEINIZING HORMONE IN CULTURES FROM RATS OF DIFFERENT AGE. P. Balbuena, J. L. Campbell, R. Clewell and H. J. Clewell. The Hamner Institutes of Health Sciences, Research Triangle Park, NC. #2553 Poster Board Number.....................................147 AN ORGANOTYPIC MICROLIVER PLATFORM FOR HIGH-THROUGHPUT DRUG TESTING. S. Messner 1 , B. Machi 1 , S. Hammad 2 , J. M. Kelm 1 , J. G. Hengstler 2 and W. Moritz 1 . 1 InSphero AG, Zürich, Switzerland and 2 IfADo Dortmund, Technical University of Dortmund, Dortmund, Germany. Sponsor: C. Corton. #2554 Poster Board Number.....................................148 QUANTIFICATION OF UVA-INDUCED REACTIVE OXYGEN SPECIES IN PRIMARY HUMAN KERATINOCYTES TREATED WITH ANTIOXIDANTS. K. Norman, H. Inglis and G. Mun. Institute for In Vitro Sciences, Gaithersburg, MD. Sponsor: E. Dahl. #2555 Poster Board Number.....................................149 IN VITRO ASSESSMENT OF SKIN IRRITATION POTENTIAL OF SURFACTANT BASED FORMULATIONS USING 3-D SKIN RECONSTRUCTED TISSUES AND CYTOKINE EXPRESSION ANALYSIS. L. Gandolfi 1 , N. Tierney 1 , D. Johnson 1 , R. Walters 1 , M. Fevola 1 , E. Gunn 1 , K. Martin 1 , A. Kong 2 , A. Hilberer 2 , N. Barnes 2 , N. Wilt 2 , J. R. Nash 2 , H. Inglis 2 , H. Raabe 2 and G. Costin 2 . 1 Johnson & Johnson, Skillman, NJ and 2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD. #2556 Poster Board Number.....................................150 USE OF EPIDERM FULL THICKNESS (EFT) SKIN CULTURES AS AN IN VITRO MODEL FOR WOUND HEALING. P. Hayden2, M. Sachdeva 1 , P. P. Shah 1 , U. S. Desai 1 , R. Patlolla 1 and M. Klausner 2 . 1 Pharmacy, Florida A&M University, Tallahassee, FL and 2 MatTek Corporation, Ashland, MA. #2557 Poster Board Number.....................................151 IN VITRO BILIARY CLEARANCE OF PERFLUOROOCTANOATE IN SANDWICH- CULTURED HEPATOCYTES FROM RATS. D. Nabb, R. Mingoia and X. Han. DuPont Haskell Global Centers for Health & Environmental Sciences, Newark, DE. #2558 Poster Board Number.....................................152 IDENTIFICATION OF NOVEL BIOMARKERS OF FORMALDEHYDE TOXICITY IN HUMANS USING FUNCTIONAL TOXICOGENOMICS IN YEAST. M. North 1 , C. Romero 1,2 , A. Loguinov 1 , M. T. Smith 2 , L. Zhang 2 and C. D. Vulpe 1 . 1 Department of Nutritional Science & Toxicology, The University of California Berkeley, Berkeley, CA and 2 Division of Environmental Health Sciences, School of Public Health, The University of California Berkeley, Berkeley, CA. Abstract # #2559 Poster Board Number.....................................153 VALIDATION RESULTS AND METHODS FOR IMPROVING IN VITRO TIER 1 ENDOCRINE DISRUPTION SCREENING ASSAYS. C. Toole, D. P. Blakeman, N. Nichols, M. Clark, H. Wagner, B. Wallace and J. M. McKim. CeeTox, Inc., Kalamazoo, MI. #2560 Poster Board Number.....................................154 A NOVEL STRATEGY FOR IN VITRO ASSAY PLATFORM TO PREDICT SKIN SENSITIZING POTENTIAL OF BROAD RAW MATERIALS. M. Miyazawa 1 , Y. Nukada 1 , K. Saito 1 , H. Sakaguchi 1 , N. Nishiyama 1 and F. Gerberick 2 . 1 Kao Corporation, Tochigi, Japan and 2 Procter & Gamble Company, Cincinnati, OH. #2561 Poster Board Number.....................................155 GENE EXPRESSION ANALYSIS OF PRECISION-CUT HUMAN LIVER SLICES INDICATE STABLE EXPRESSION OF HEPATOXICITY RELATED GENES. M. G. Elferink 2 , P. Olinga 1 , E. M. van Leeuwen 3 , S. Bauerschmidt 3 , J. Polman 3 , W. G. Schoonen 4 , S. H. Heisterkamp 5,6 and G. M. Groothuis 2 . 1 Pharmaceutical Technology and Biopharmacy, Groningen Research Institute for Pharmacy, Groningen, Netherlands, 2 Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, Groningen, Netherlands, 3 Molecular Design and Informatics, MSD, Oss, Netherlands, 4 Toxicology &Drug Disposition, MSD, Oss, Netherlands, 5 Biostatistics and Research Decision Sciences, MSD, OSS, Netherlands and 6 Bioinformatics Centre, University of Groningen, Groningen, Netherlands. Sponsor: A. Vickers. #2562 Poster Board Number.....................................156 MEDIA SERUM LEVELS AND IN VITRO HEPATIC ABSORPTION OF LINDANE. E. L. Croom and R. A. Pegram. Office of Research and Development, National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC. #2563 Poster Board Number.....................................157 AN IN VITRO MODEL FOR THE STUDY OF BACTERIAL COLONIZATION OF HUMAN EXTRAPLACENTAL MEMBRANES: ROLE OF ANTIMICROBIAL PEPTIDES. E. Boldenow 1 , S. Jones 1 , C. Xi 1 , R. Lieberman 2 and R. Loch-Caruso 1 . 1 Environmental Health Sciences, University of Michigan, Ann Arbor, MI and 2 Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI. #2564 Poster Board Number.....................................158 EVALUATION OF AN ORAL CARE PRODUCT SAFETY SCREENING PROGRAM UTILIZING THE IN VITRO SKINETHIC HUMAN GINGIVAL EPITHELIUM (RHG) AND ORAL BUCCAL (RHO) MODELS. L. Wurzburger 1 , P. Kazmi 1 , T. Re 1 , A. Alonso 2 , B. Bertino 2 , N. Barnes 3 , A. de Brugerolle de Fraissinette 2 , A. Hilberer 3 , H. Raabe 3 , N. Wilt 3 and V. Srinivasan 1 . 1 L’Oreal USA Products, Clark, NJ, 2 SkinEthic Laboratories, Nice, France and 3 Institute for In Vitro Sciences, Inc., Gaithersburg, MD. Thursday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 345
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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