Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # #2278 Poster Board Number.....................................422 TOXICOKINETICS OF CAPTAN BIOMARKERS IN ORALLY AND DERMALLY EXPOSED VOLUNTEERS. M. Bouchard 1 , A. Berthet 1,2 and D. Vernez 2 . 1 Department Environmental & Occupational Health, University of Montréal, Montréal, QC, Canada and 2 Institute for Work and Health, Lausanne, Switzerland. #2279 Poster Board Number.....................................423 IMPACT OF NON-LINEAR PHARMACOKINETICS AND METABOLISM OF CHLORPYRIFOS ON BIOLOGICAL RESPONSE IN THE RAT. M. Bartels 1 , M. S. Marty 1 , J. A. Hotchkiss 1 and D. R. Juberg 2 . 1 Toxicology, Dow Chemical, Midland, MI and 2 Toxicology, Dow AgroSciences, Indianapolis, IN. #2280 Poster Board Number.....................................424 COMPARISON OF THE EFFECT OF ASSAY CONDITIONS ON INTERPRETATION OF TIME-DEPENDENT INHIBITION OF CYTOCHROME P450 ENZYMES USING SINGLE POINT AND IC50 SHIFT ASSAYS. K. Fox 2 , R. Pearson 2 , P. Butler 2 , C. Dilworth 2 and K. Tsaioun 1,2 . 1 Apredica, Watertown, MA and 2 Cyprotex, Macclesfield, United Kingdom. #2281 Poster Board Number.....................................425 REACTIVITY OF BRO3- EXPLAINS POOR APPARENT ABSORPTION OF LOW ORAL DOSES F344 RATS. R. J. Bull 1 , N. Kolisetty 2 , Z. Guo 3 , J. W. Fisher 4 , J. A. Cotruvo 5 and B. S. Cummings 2 . 1 Washington State University, Richland, WA, 2 University of Georgia, Athens, GA, 3 Center for Water Technology Public Utility Board Singapore, Singapore, 4 U.S. FDA, Jefferson, AR ad 5 Joseph Cotruvo & Associates LLC, Washington, D.C. #2282 Poster Board Number.....................................426 GENETIC VARIATION IN ISOGENIC STRAINS OF LABORATORY MICE ALTERS DISPOSITION IN KIDNEYS AND LIVERS AFTER ACUTE EXPOSURE TO [14C] BENZENE. R. Kuester 1 , G. A. Knudsen 1 , M. L. Cunningham 2 and G. Sipes 1 . 1 Department of Pharmacology, University of Arizona, Tucson, AZ and 2 NTP NIEHS, Montréal, QC, Canada. #2283 Poster Board Number.....................................427 PYRIDAZINE REDUCES TRICHLOROACETIC ACID (TCA) BIOAVAILABILITY BY ENHANCING ITS URINARY ELIMINATION. J. Bruckner, S. Lee, C. A. White, S. Muralidhara and R. Govindaarajan. PBS, University of Georgia, Athens, GA. #2284 Poster Board Number.....................................428 DETERMINATION OF TACROLIMUS IN RAT WHOLE BLOOD USING DRIED BLOOD SPOT ANALYSES BY LC-MS/MS. M. Kim 1 , G. Ray 1 , Y. Liu 1 , R. Losson 2 and G. Bricker 2 . 1 KCAS, Shawnee, KS and 2 Xenometrics, Stilwell, KS. Sponsor: D. Dandekar. #2285 Poster Board Number.....................................429 A SENSITIVE LC-MS/MS ASSAY FOR DETERMINATION OF BENAZEPRIL AND BENAZEPRILAT IN DOG PLASMA. C. Chung, M. Luna, Y. Liu, G. Ray and D. Dadgar. KCAS, Shawnee, KS. Sponsor: D. Dandekar. Wednesday Afternoon, March 9 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Risk Assessment: Models and Approaches for Inhaled Agents Chairperson(s): Annie Jarabek, U.S. EPA, Research Triangle Park, NC, and Richard Corley, Pacific Northwest National Laboratory, Richland, WA. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #2286 Poster Board Number.....................................432 EVALUATION OF ADVERSE EFFECTS ON HUMAN LUNG FUNCTION CAUSED BY OZONE. R. L. Prueitt 1 and J. E. Goodman 2 . 1 Gradient, Seattle, WA and 2 Gradient, Cambridge, MA. #2287 Poster Board Number.....................................433 MODELING NF-κB REDOX SENSITIVITY: APPLICATIONS TO OZONE-INDUCED LUNG INFLAMMATION. D. J. Miller and P. D. White. U.S. EPA, Washington, D.C. Sponsor: S. Vulimiri. #2288 Poster Board Number.....................................434 COMBINED CFD/PBPK MODELS FOR DETERMINING SITE-SPECIFIC UPTAKE AND TISSUE CONCENTRATIONS OF REACTIVE GASES IN THE RESPIRATORY TRACT OF RATS AND HUMANS. R. A. Corley 1 , S. Kabilan 1 , J. E. Carson 1 , R. Jacob 1 , K. R. Minard 1 , R. W. Glenny 2 , S. Pipavath 2 , M. Fanucchi 3 and D. R. Einstein 1 . 1 Pacific Northwest National Laboratory, Richland, WA, 2 University of Washington, Seattle, WA and 3 University of Alabama at Birmingham, Birmingham, AL. #2289 Poster Board Number.....................................435 MODELING VAPOR UPTAKE AND TISSUE DISPOSITION IN HUMAN LUNGS. M. Singal 1 , B. Asgharian 2 , O. T. Price 2 , J. S. Schroeter 3 and J. S. Kimbell 4 . 1 Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ, 2 Health Effects & Medical Response, Applied Research Associates, Raleigh, NC, 3 Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC and 4 Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC. #2290 Poster Board Number.....................................436 DOSIMETRY OF SOLUBLE, REACTIVE VAPORS IN THE UPPER RESPIRATORY TRACT OF THE SPRAGUE-DAWLEY RAT USING A COMPUTATIONAL FLUID DYNAMICS MODEL. J. Schroeter 1 , J. S. Kimbell 2 , B. Asgharian 3 and M. Singal 4 . 1 The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 2 Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3 Applied Research Associates, Inc., Raleigh, NC and 4 Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ. 318 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #2291 Poster Board Number.....................................437 MODELS FOR EVALUATION OF THERAPEUTIC INTERVENTION OF INTERNALLY DEPOSITED AMERICIUM. R. A. Guilmette 1 , W. M. Weber 1 , M. Doyle-Eisele 1 , G. Miller 2 , L. Bertelli 2 and J. D. McDonald 1 . 1 Lovelace Respiratory Research Institute, Albuquerque, NM and 2 Los Alamos National Laboratories, Los Alamos, NM. #2292 Poster Board Number.....................................438 MODELING FIBER INHALABILITY AND DEPOSITION IN THE HUMAN AND RAT RESPIRATORY TRACT. B. Asgharian 1 , O. T. Price 1 , S. H. Gavett 2 and A. M. Jarabek 2 . 1 Health Effects & Medical Response, Applied Research Associates, Raleigh, NC and 2 U.S. EPA, Research Triangle Park, NC. #2293 Poster Board Number.....................................439 TRANSLATION OF INHALED FIBER DOSE ACROSS SPECIES AND DIFFERENT EXPERIMENTAL DESIGNS: FIBER EQUIVALENT DIAMETER. O. Price 1 , B. Asgharian 1 , S. H. Gavett 2 and A. M. Jarabek 2 . 1 Applied Research Associates, Inc., Raleigh, NC and 2 U.S. EPA, Research Triangle Park, NC. #2294 Poster Board Number.....................................440 DEVELOPMENT OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR THE DISPOSITION OF PROPYL SERIES COMPOUNDS (PROPYL ACETATE, PROPANOL, PROPIONALDEHYDE, AND PROPIONIC ACID) IN RATS. L. M. Sweeney 1,2 and T. S. Poet 3 . 1 Naval Medical Research Unit-Dayton, Wright- Patterson Air Force Base, Wright-Patterson Air Force Base, OH, 2 Toxicology Excellence for Risk Assessment, Cincinnati, OH and 3 Battelle Pacific Northwest National Laboratory, Richand, WA. #2295 Poster Board Number.....................................441 USING MARGINS OF EXPOSURE AS A SEGREGATION TOOL FOR RISK ASSESSMENT OF TOBACCO SMOKE TOXICANTS. S. Fiebelkorn, F. H. Cunningham and C. Meredith. Group R&D, British American Tobacco, Southampton, United Kingdom. #2296 Poster Board Number.....................................442 USE OF CONTROL BANDING AND SENSORY IRRITATION (RD 50 ) DATA TO ASSESS OCCUPATIONAL EXPOSURE VALUES FOR N-PROPYL, N-BUTYL, AND N-PENTYL PROPIONATE. S. M. Krieger 1 , D. R. Geter 1 , T. J. Cawley 1 , M. Osterloh-Quiroz 2 and J. A. Hotchkiss 1 . 1 The Dow Chemical Company, Midland, MI and 2 Dow Europe GmbH, Horgen, Switzerland. #2297 Poster Board Number.....................................443 ASSESSING NON-CANCER HEALTH RISK FROM INHALED PCBS. G. M. Lehmann 1 and J. Schaum 2 . 1 ORD, U.S. EPA, Research Triangle Park, NC and 2 ORD, U.S. EPA, Washington, D.C. Abstract # #2298 Poster Board Number.....................................444 STRUCTURE-ACTIVITY MODELS FOR CHEMICAL INHALATION HEALTH GUIDANCE VALUES. C. J. Collar 1 , T. Miller 2 , R. M. Garrett 2 and E. Demchuk 1 . 1 Division of Toxicology and Environmental Medicine, ATSDR/ CDC, Atlanta, GA and 2 Department of Defense, Washington, D.C. Sponsor: B. Fowler. #2299 Poster Board Number.....................................445 THORACIC DAMPING AND THE RELATIONSHIP BETWEEN PENH OF THE THORACIC AIR-FLOW (I T ) AND TIDAL MIDEXPIRATORY FLOW (EF 50 ). D. G. Frazer, J. S. Reynolds, W. T. Goldsmith, W. G. McKinney, M. C. Jackson and A. A. Afshari. HELD, CDC / NIOSH, Morgantown, WV. Sponsor: A. Hubbs. #2300 Poster Board Number.....................................446 FRONT-LINE CELLS IN LUNG DISEASE: SUB-CELLULAR LOCALIZATION OF PROTEINS WHOSE STATES ARE DEPENDENT ON THAT OF CDKN2A. G. Acquaah-Mensah. Massachusetts College of Pharmacy & Health Sciences, Worcester, MA. #2301 Poster Board Number.....................................447 HOW MUCH FORMALDEHYDE EXISTS IN EXHALED BREATH? J. E. Whalan, D. DeVoney and S. V. Vulimiri. U.S. EPA, Washington, D.C. #2302 Poster Board Number.....................................448 DNA DAMAGE AND OXIDATIVE STRESS IN RATS INTRATRACHEALLY EXPOSED TO LOW-LEVEL COMBINED COBALT AND CHROMIUM. N. Yoshioka 1 , K. Hosoda 1 , H. Nakashima 2 , T. Michikawa 1 , M. Nakano 1 and K. Omae 1 . 1 Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan and 2 Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan. Wednesday Afternoon, March 9 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Mechanistic Assessment of Chemical Mixtures Chairperson(s): Rory B. Conolly, U.S. EPA, Research Triangle Park, NC. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #2303 Poster Board Number.....................................501 MODELING MIXTURES OF ENVIRONMENTAL ESTROGENS DETECTED IN U.S. SURFACE WATERS WITH AN IN VITRO ESTROGEN MEDIATED TRANSCRIPTIONAL ACTIVATION ASSAY (T47D-KBLUC). D. S. Bermudez 1,2 , L. Gray 2 and V. S. Wilson 2 . 1 Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC and 2 Reproductive Toxicology Branch, U.S. EPA, Research Triangle Park, NC. Wednesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 319
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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