Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
Monday Afternoon, March 7
2:00 PM to 4:45 PM
Room 207
Environment and Disease
Symposium Session: Human Variability in Susceptibility to
Environmental Toxicants
Chairperson(s): Holly Mortensen, U.S. EPA, Durham, NC, and
Susan Euling, U.S. EPA, Washington, D.C.
Sponsor:
Molecular Biology Specialty Section
Endorsed by:
Regulatory and Safety Evaluation Specialty Section
Risk Assessment Specialty Section
Defining the differing levels of susceptibility across human populations
in response to environmental chemicals can provide information to define
population risk factors and in turn, allow for risk levels to be based on the
most susceptible populations. Data from high-throughput/high content (HT/
HC) technologies, including 'omics, have been integral in the identification
and characterization of drug-target or disease loci and have the potential
to be informative for characterizing the effects and dose-response assessment
of chemical exposure and outcomes within genetically heterogeneous
populations. Many of the same 'omics technologies have been successfully
utilized to provide data that informs the mechanism of action for
environmental chemicals, including the identification of perturbed toxicity
pathways. In addition, large scale population genotyping studies, such as the
HapMap, can help to establish levels of variability at chemical-associated,
target loci across human populations, and in comparison to genome-wide
patterns. Individual genotype-phenotype combinations can then be verified
using in vitro methods, or extrapolation from animal models. This session
includes talks on some of the latest approaches to informing population
variability and the identification of susceptible populations through the use
of HT/HC data, particularly from genomics technologies. We will discuss
how 'omics data in combination with data from enhanced animal models,
publically available datasets and related computational tools can be used
to identify biomarkers, and subsequently define risk for genetically heterogeneous
populations, and how this variability translates to human risk and
progression of disease.
#819 2:00 HUMAN VARIABILITY IN SUSCEPTIBILITY
TO ENVIRONMENTAL TOXICANTS. ​H.
Mortensen. NCCT, U.S. EPA, Research Triangle
Park, NC.
2:00 INTRODUCTION. ​Holly Mortensen
#820 2:05 POPULATION-BASED DISCOVERY OF
TOXICOGENOMICS BIOMARKERS FOR
HEPATOTOXICITY. ​I. Rusyn. Environmental
Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC.
#821 2:37 EXPERIMENTALLY DEFINING TOXICITY
PATHWAYS USING IN VITRO HIGH-
CONTENT SCREENING OF EMBRYONIC
FIBROBLASTS FROM THE MOUSE
DIVERSITY PANEL. ​R. Thomas. Genomic
Biology and Bioinformatics, The Hamner Institutes
for Health Sciences, Research Triangle Park, NC.
#822 3:09 HERITABILITY IN DOSE RESPONSE -
PUTTING THE HORSE BEFORE THE CART. ​
A. Motsinger-Reif. Department of Statistics, North
Carolina State University, Raleigh, NC. Sponsor: H.
Mortensen.
Abstract #
#823 3:41 ASSOCIATION OF GENETIC
POLYMORPHISMS, MRNA EXPRESSION
OF P53 AND P21 WITH CHRONIC
BENZENE POISONING IN A CHINESE
OCCUPATIONAL POPULATION. ​N. Rothman.
Division of Cancer Epidemiology and Genetics,
National Cancer Institute, Bethesda, MD. Sponsor:
H. Mortensen.
#824 4:13 PERSONALIZED MEDICINE,
INDIVIDUALIZED DRUG THERAPY:
CAN THESE GOALS BE REALISTICALLY
ACHIEVED? ​D. W. Nebert. Departments of
Environmental Health & Pediatrics, Division of
Human Genetics, University Cincinnati Medical
Center, Cincinnati, OH.
Monday Afternoon, March 7
2:00 PM to 4:45 PM
Room 204
Symposium Session: Toxicological Considerations in the Gulf
of Mexico Oil Spill
Chairperson(s): Michael Madden, U.S. EPA, Chapel Hill, NC, and
Michael Ottlinger, U.S. EPA, Cincinnati, OH.
Sponsor:
Occupational Public Health Specialty Section
The Deepwater Horizon oil rig explosion on April 20, 2010 resulted in a
release of petroleum crude oil into Gulf of Mexico waters. The release,
41 miles offshore, was about 1 mile in Department Oil dispersants were
employed to change surface oil and underwater properties. Surface oil was
also combusted and physical barriers deployed. Oil was estimated to have
spread to an estimated 2500 square mile in the Gulf. On July 15, the well
head was capped reducing oil flow to a minimum. A number of exposure
uncertainties have arisen as a result of the spill related to the locations
the oil has dispersed to, including volatilization to the atmosphere; and
the dose of contaminant reaching wildlife, humans, and vegetation in the
affected areas, and physicochemical properties of the dispersant-treated
and aged oil. We will present findings related to understanding the migration
of the spill components, the habitats and organisms contaminated, and
the characteristics of altered crude. Routes of exposure for humans to oil
components will be presented in part based on data from other studied oil
spills. Knowledge of these currently unsure parameters will assist in understanding
the potential biological and health effects induced by the spill. The
major possible ecological effects will be described and compared to the
normal Gulf ecosystem dynamics. The choice of the specific oil dispersants
utilized will be discussed with an emphasis on the toxicity assays employed;
toxicity endpoints still not fully examined will be identified. The types and
likelihood of possible human adverse health effects, both acute and latent,
will be presented in light of what will be known of the exposure routes
and the conditions (e.g. heat). In order to comprehend possible effects in a
comprehensive manner in order to develop estimates of various risks, the
data sources available to perform such an assessment will be identified (e.g.,
estimates of contaminated seafood consumption). Finally, data deficiencies
needed for risk assessment will be described.
#825 2:00 TOXICOLOGICAL CONSIDERATIONS IN
THE GULF OF MEXICO OIL SPILL. ​M. C.
Madden. ORD, NHEERL, HSD, Clinical Research
Branch, U.S. EPA, Chapel Hill, NC.
#826 2:00 THE GULF OF MEXICO ECOSYSTEM:
CONSEQUENCES OF THE BP OIL SPILL. ​W.
Benson, S. Jordan, R. Greene, V. Engle, M. Hemmer
and M. Barron. Gulf Ecology Division, U.S. EPA,
Gulf Breeze, FL.
MONday
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