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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 204 Platform Session: Computational Approaches to Address DILI and Hepatoxicity Chairperson(s): Amy Wang, U.S. Environmental Protection Agency, Research Triangle Park, NC, and Raymond Kemper, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT. #934 9:00 THE FDA’S LIVER TOXICITY KNOWLEDGE BASE (LTKB) PROJECT. W. Tong 1 , M. Chen 1 , V. Vikrant 1 , Q. Shi 1 , M. Zhang 1 , L. Guo 2 , Z. Liu 1 , J. Zhang 1 and E. Bearden 1 . 1 Division of Systems Biology, U.S. FDA NCTR, Jefferson, AR and 2 Division of Biochemical Toxicology, U.S. FDA NCTR, Jefferson, AR. #935 9:21 VALIDATION OF CELLCIPHR CELLULAR SYSTEMS BIOLOGY (CSB) TECHNOLOGY. CELLCIPHR2— BUILDING ON EXPERIENCE OF IN VIVO RAT LIVER INJURY PREDICTION TO DEVELOP THE HUMAN DILI PREDICTION. S. Thomas 2 , J. Mein 2 , R. Annand 1 , P. Walker 2 , M. Jacewicz 1 , D. Steen 3 , C. Chesne 3 , J. Gilbert 1,2 and K. Tsaioun 1,2 . 1 Apredica, Watertown, MA, 2 Cyprotex, Macclesfield, United Kingdom and 3 Biopredic, Rennes, France. #936 9:42 INVESTIGATING THE ROLE OF MITOCHONDRIAL TOXICITY IN DRUG- INDUCED LIVER INJURY VIA CONGRUENT STRUCTURE-ACTIVITY RELATIONSHIPS. M. L. Patel 1 , L. Fisk 1 , N. Greene 2 and R. T. Naven 2 . 1 Lhasa Limited, Leeds, United Kingdom and 2 Worldwide Medicinal Chemistry, Pfizer Inc., Groton, CT. #937 10:03 QUANTITATIVE SIMULATION OF INTRACELLULAR SIGNALING CASCADES IN A VIRTUAL LIVER: ESTIMATING DOSE DEPENDENT CHANGES IN HEPATOCELLULAR PROLIFERATION AND APOPTOSIS. J. Jack 1 , M. Mennecozzi 2 , C. Haugh 1 , J. Wambaugh 1 and I. Shah 1 . 1 National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, NC and 2 Joint Research Centre, European Commission, Ispra, Italy. #938 10:24 PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING TO PREDICT PLASMA PHARMACOKINETICS FOR LIVER TRANSPORTER SUBSTRATES. H. A. Barton 1 , H. Jones 2 and Y. Lai 1 . 1 Pharmacokinetics, Pharmacodynamics, and Metabolism, Pfizer, Inc., Groton, CT and 2 Pharmacokinetics, Pharmacodynamics, and Metabolism, Pfizer, Inc., Sandwich, United Kingdom. #939 10:45 A NOVEL PREDICTIVE PLATFORM FOR DILI: A COMBINATION OF IN SILICO AND IN VITRO METHODS TO PREDICT TOXICITY MECHANISMS IN VIVO. S. Das, R. Kumar, S. Raghavan and K. Subramanian. Strand Life Sciences, Bangalore, India. #940 11:05 APPLICATIONS OF A COMPUTATIONAL MODEL FOR PREDICTING DRUG- INDUCED LIVER INJURY (DILI). B. A. Howell 1 , R. Kumar 3 , L. Wennerberg 3 , Y. Yang 2 , R. Ho 3 , A. Harrill 1 , C. L. Kurtz 1 , M. E. Andersen 2 , H. J. Clewell 2 , S. Q. Siler 3 and P. B. Watkins 1 . 1 Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, NC, 2 Chemical Safety Sciences, The Hamner Institutes, Research Triangle Park, NC and 3 Entelos, Inc., Foster City, CA. #941 11:25 DEVELOPMENT OF A PBPK/PD MODEL FOR ACETAMINOPHEN TOXICITY IN RATS. Y. Yang, B. Howell, M. Yoon, M. Andersen and H. J. Clewell. The Hamner Institutes for Health Sciences, Research Triangle Park, NC. Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 201 Epigenetic Mechanisms Platform Session: Epigenetic Mechanisms in Development and Disease Chairperson(s): Yanan Tian, Texas A&M University, College Station, TX, and Xiefan Fang, University of Mississippi, University, MS. #942 9:00 USING ZEBRAFISH TO STUDY BENZO(A) PYRENE-MEDIATED CHANGES IN DNA METHYLATION STATUS DURING DEVELOPMENT. X. Fang 1 , C. Thornton 1 , B. E. Scheffler 2 and K. L. Willett 1 . 1 Department of Pharmacology and Toxicology, the University of Mississippi, University, MS and 2 Genomics and Bioinformatics Research Unit, USDA Mid South Area Genomics Laboratory, Stoneville, MS. #943 9:19 GENOME-WIDE DNA METHYLATION DIFFERENCES BETWEEN LATE- ONSET ALZHEIMER’S DISEASE AND COGNITIVELY NORMAL CONTROLS IN THE HUMAN FRONTAL CORTEX. K. Bakulski 1 , D. C. Dolinoy 1 , M. A. Sartor 1 , H. L. Paulson 2 , A. P. Lieberman 2 , R. L. Albin 2 , H. Hu 1,2 and L. S. Rozek 2 . 1 School of Public Health, University of Michigan, Ann Arbor, MI and 2 Medical School, University of Michigan, Ann Arbor, MI. #944 9:38 EPIGENETIC CHANGES DURING CO-CARCINOGENESIS OF N, N-DIETHYLNITROSAMINE AND CARBON TETRACHLORIDE IN MOUSE LIVER. K. Kutanzi 1 , I. Koturbash 1 , T. Uehara 2 , O. Kosyk 2 , I. Pogribny 1 and I. Rusyn 2 . 1 National Center for Toxicological Research, U.S. FDA, Jefferson, AR and 2 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC. #945 9:57 AH RECEPTOR INHIBITS GENE EXPRESSION OF DELETED IN LIVER CANCER (DLC1) THROUGH REGULATION OF MICRORNA IN MOUSE LIVER CELLS. Y. Tian 1 , S. Ke 1 , M. Huang 2 , B. Zhou 1 and Z. Zhou 2 . 1 Program of Toxicology, Texas A&M University, College Station, TX and 2 School of Public Health, Fudan University, Shanghai, China. 200 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #946 10:15 INTER-STRAIN DIFFERENCES IN SUSCEPTIBILITY TO 1, 3-BUTADIENE- INDUCED DNA DAMAGE, EPIGENETIC AFFECTS, AND HEPATOTOXICITY. I. Pogribny 1 , K. Igor 1 , A. Scherhag 1 , J. Sorrentino 2 , S. Kennet 2 , W. Bodnar 2 , S. A. James 2 , B. A. Frederick 1 and R. Ivan 2 . 1 National Center for Toxicological Research, Jefferson, AR and 2 University of North Carolina, Chapel Hill, NC. #947 10:33 ALTERED DNA METHYLATION PATTERNS IN INDIVIDUALS WITH ARSENICOSIS. L. Smeester 1 , J. Rager 1 , L. Zhang 6 , X. Guan 3 , N. Smith 1 , G. Garcia-Vargas 4 , L. Del Razo 5 , Z. Drobna 2 , H. Kelkar 3 , G. Schroth 6 , M. Styblo 2 and R. Fry 1 . 1 Environmental Sciences and Engineering, Gillings School of Global Public Health University of North Carolina at Chapel Hill, Chapel Hill, NC, 2 Nutrition, Gillings School of Global Public Health University of North Carolina at Chapel Hill, Chapel Hill, NC, 3 Center for Bioinformatics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4 Faculty of Medicine, Juarez University of Durango State, Juarez, Mexico, 5 Department of Toxicology, Cinvestav-Ipn, Mexico City, Mexico and 6 Illumina, Inc., Hayward, CA. #948 10:51 HDAC INHIBITORS, ENTINOSTAT, AND VORINOSTAT SYNERGIZE WITH ADAPHOSTIN, A TYRPHOSTIN KINASE INHIBITOR, INCREASING OXIDATIVE STRESS AND APOPTOSIS IN LEUKEMIA CELLS. N. Rivera-Del Valle and J. Chandra. Pediatric Research, University of Texas M.D. AndersonCancer Center, Houston, TX. #949 11:09 AHR-MEDIATED IMMUNE REGULATION RESULTS FROM EPIGENETIC EFFECTS. P. Nagarkatti, N. P. Singh, U. Singh and M. Nagarkatti. Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC. #950 11:27 DNA METHYLATION AND HISTONE MODIFICATION CHANGES IN THE LIVERS OF C57BL/6J MICE EXPOSED TO 1, 3-BUTADIENE BY INHALATION. I. Koturbash 1 , A. Scherhag 1 , S. Jessica 2 , B. Wanda 2 , S. A. James 2 , B. A. Frederick 1 , P. Igor 1 and R. Ivan 2 . 1 Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR and 2 University of North Carolina, Chapel Hill, NC. Tuesday Morning, March 8 9:00 AM to 11:45 AM Room 202B Platform Session: Gene Regulatory Mechanisms of Carcinogenesis Chairperson(s): David Castro, Sanford-Burnham Medical Research Institute, La Jolla, CA, and B. Bhaska Gollapudi, The Dow Chemical Company, Midland, MI. #951 9:00 PROPICONAZOLE ENHANCES CELL PROLIFERATION BY DYSREGULATION OF RAS FARNESYLATION AND THE MAPK PATHWAY. L. Murphy, T. Moore and S. Nesnow. U.S. EPA, Research Triangle Park, NC. Sponsor: S. Hester. Abstract # #952 9:21 ANALYSIS OF MOLECULAR, CELLULAR, AND BIOCHEMICAL CHANGES IN THE LIVER OF MALE B6C3F1 MICE TREATED WITH NITRAPYRIN—A NITROGEN STABILIZER. M. J. LeBaron 1 , M. R. Schisler 1 , H. L. Kan 1 , J. Thomas 1 , D. L. Eisenbrandt 2 and B. B. Gollapudi 1 . 1 The Dow Chemical Company, Midland, MI and 2 Dow AgroSciences, Indianapolis, IN. #953 9:42 THE FRY TUMOR SUPPRESSOR ENCODES AN INHIBITOR OF EPITHELIAL MESENCHYMAL TRANSITION. J. Graham 1 , X. Ren 2 and H. Zarbl 1 . 1 Toxicology, UMDNJ- RWJMS, Piscataway, NJ and 2 University of California, Berkeley, CA. #954 10:03 REDUCTION OF PTEN DOSE IMPAIRS DNA REPAIR AND PREDISPOSES TO UVB- INDUCED SKIN TUMORIGENESIS. Y. He 1 , M. Ming 1 , L. Feng 2 , C. Shea 1 , K. Soltani 1 , B. Zhao 2 , W. Han 1 , R. Smart 3 , C. Trempus 2 and J. Pritchard 2 . 1 Medicine/Dermatology, University of Chicago, Chicago, IL, 2 Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC and 3 Department of Environmental and Molecular ToxicologyGroup, North Carolina State University, Raleigh, NC. #955 10:24 TOLFENAMIC ACID INHIBITS GROWTH AND SURVIVAL OF MULTIPLE TUMORS AND DOWNREGULATES SPECIFICITY PROTEIN (SP) TRANSCRIPTION FACTORS. G. Chadalapaka 1 , I. Jutooru 1 , S. Sreevalsan 1 , S. Pathi 1 and H. Wilson 2 . 1 VTPP, Texas A&M University, College Station, TX and 2 Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX. #956 10:45 ROLE OF SPECIFICITY PROTEIN (SP) TRANSCRIPTION FACTORS IN REGULATION OF STAT3 IN PANCREATIC CANCER CELLS. I. D. Jutooru 1 , G. Chadalapaka 1 and S. H. Safe 1,2 . 1 Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX and 2 Institute of Biosciences & Technology, Houston, TX. #957 11:05 PEROXISOME PROLIFERATOR- ACTIVATED RECEPTOR (PPAR)γ IN MAMMARY SECRETORY EPITHELIAL CELLS STOPS DMBA-MEDIATED BREAST TUMOURIGENESIS. A. J. Apostoli 1 , N. Peterson 1 , R. Rubino 1 , S. SenGupta 1 , M. Schneider 1 and C. Nicol 1,2 . 1 Pathology & Molecular Medicine, Queen’s University, CRI, Kingston, ON, Canada and 2 Division of Cancer Biology & Genetics, Queen’s University, CRI, Kingston, ON, Canada. #958 11:25 MITOCHONDIAL UNCOUPLING PROTEIN 3 ANTAGONIZES TUMOR PROMOTION BY ALTERING CANONICAL KERATINOCYTE GROWTH AND DIFFERENTIATION SIGNALING PATHWAYS. S. M. Nowinski 1 , J. E. Rundhaug 2 , O. Rho 1 , J. Digiovanni 1 and E. M. Mills 1 . 1 Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX and 2 Science Park - Research Division, The University of Texas M.D. AndersonCancer Center, Smithville, TX. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 201
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 ToxExpo
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Creating a Safer and Healthier Worl
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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