Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#1154 Poster Board Number.....................................602
RADIATION AND SENESCENCE:
DECELERATION OF CELL-CYCLE IN
PRIMITIVE HEMOPOIETIC PROGENITORS
(CFU-S13) WAS ONLY SIGNIFICANT
PARAMETER DURING AGING, WHICH
WAS REACTIVELY ACCELERATED AFTER
2GY WHOLE-BODY IRRADIATION. ​Y.
Hirabayashi 1 , I. Tsuboi 2 , K. Sekita 1 , J. Kanno 1 , Y.
Kusunoki 3 and T. Inoue 1,2,3 . 1 NCBCR, NIHS, Tokyo,
Japan, 2 School of Medicine, Nihon University,
Tokyo, Japan and 3 RERF, Hiroshima, Japan.
#1155 Poster Board Number.....................................603
CADMIUM-INDUCED TRANSFORMATION
OF HUMAN STEM CELLS. ​E. Tokar and M.
Waalkes. National Toxicology Program, NIEHS,
Research Triangle Park, NC.
#1156 Poster Board Number.....................................604
GROWTH HORMONE VS. PEGYLATED GH
LIPOATROPHY IN HUMAN STEM CELL
DERIVED ADIPOCYTES. ​P. M. Bartholomew 1 ,
C. Donahue 2 , M. Thiede 2 , S. Martin 3 and J. Vajdos 2 .
1
Drug Safety R&D, Pfizer Inc., Groton, CT,
2
Genetically Modified Models, Pfizer Inc., Groton,
CT and 3 Pharm R&D, Pfizer Inc., Groton, CT.
#1157 Poster Board Number.....................................605
DIOXIN, A POTENT LIGAND OF THE
ARYL HYDROCARBON RECEPTOR,
ALTERS MIGRATION OF MURINE
HEMATOPOIETIC STEM CELLS. ​F. L.
Casado-Pena, K. P. Singh and T. A. Gasiewicz.
Environmental Medicine, University of Rochester,
Rochester, NY.
#1158 Poster Board Number.....................................606
ARYL HYDROCARBON RECEPTOR
AGONIST DIOXIN PRODUCES
ALTERATIONS IN EARLY HEMATOPOIESIS
IN MOUSE FETAL LIVER. ​K. P. Singh, F.
L. Casado and T. A. Gasiewicz. Environmental
Medicine, University of Rochester Medical Center,
Rochester, NY.
#1159 Poster Board Number.....................................607
INVOLVEMENT OF AMPK IN SUNITINIB
MEDIATED CARDIOTOXICITY IN
HUMAN STEM CELL DERIVED
CARDIOMYOCYTES. ​J. D. Cohen, S. Kameoka,
J. Babiarz, T. Weiser, T. Singer and K. Kolaja.
Nonclinical Safety, Hoffmann-La Roche, Nutley, NJ.
#1160 Poster Board Number.....................................608
HYPOTHERMOSOL—DERISKING A
VEHICLE. ​C. Potter 1 , K. Hedley 1 , M. Sharpe 1 , P.
Cleall 1 , A. Raber 2 , W. Vant Hof 2 , R. Deans 2 and A.
Mathew 3 . 1 Pfizer, Sandwich, Kent, United Kingdom,
2
AtherSys, Cleveland, OH and 3 Biolife Solutions,
Bothell, WA.
#1161 Poster Board Number.....................................609
CARDIAC TROPONIN I AS A MARKER
OF CARDIOTOXICITY IN HUMAN-
INDUCED PLURIPOTENT STEM CELL
CARDIOMYOCYTES. ​R. Abrams 1 , M. Dunn 1 ,
D. Coluccio 1 , G. Hirkaler 1 , J. Babiarz 1 , R. Nicklaus 1 ,
W. Geng 1 , I. Mikaelian 1 , T. Singer 2 and K. Kolaja 1 .
1
Nonclinical Safety, Roche, Nutley, NJ and
2
Nonclinical Safety, Roche, Basel, Switzerland.
Abstract #
#1162 Poster Board Number.....................................610
IN VITRO TOXICITY OF (THIO)ARSENATES
FOR HUMAN UROTHELIAL CELLS
(UROTSA) AND HEPATOCYTES (HEPG2). ​S.
Rabieh 1 , R. Lohmayer 1 , S. Hinrichsen 1 , E. Dopp 2 and
B. Planer–Friedrich 1 . 1 Environmental Geochemistry,
University of Bayreuth, Bayreuth, Germany and
2
Institute of Hygiene and Occupational Medicine,
University Hospital Essen, Essen, Germany.
#1163 Poster Board Number.....................................611
THE MRNA AND MIRNA PROFILE OF
HUMAN IPS-CELLS DIFFERENTIATING TO
CARDIOMYOCYTES. ​J. Babiarz 1 , M. Ravone 2 ,
B. Anson 3 , C. Kendrick-Parker 3 , E. Nuywasir 3 , T.
Weiser 2 , T. Singer 2 , E. Chiao 1 , U. Certa 2 and K.
Kolaja 1 . 1 Nonclinical Safety, F. Hoffman-La Roche,
Nutley, NJ, 2 Nonclinical Safety, F. Hoffman-La
Roche, Basel, Switzerland and 3 Cellular Dynamics
International, Madison, WI.
#1164 Poster Board Number.....................................612
USE OF INDUCED PLURIPOTENT
CELL-DERIVED CARDIOMYOCYTES
TO PREDICT AND INVESTIGATE DRUG-
INDUCED CARDIAC INJURY. ​S. Kameoka 1 ,
J. Babiarz 1 , B. Anson 3 , C. Kendrick-Parker 3 , E.
Nuwaysir 3 , T. Weiser 2 , T. Singer 2 , E. Chiao 1 and K.
Kolaja 1 . 1 Nonclinical Safety, F. Hoffman-La Roche,
Nutley, NJ, 2 Nonclinical Safety, F. Hoffman-La
Roche, Basel, Switzerland and 3 Cellular Dynamics
International, Madison, WI.
#1165 Poster Board Number.....................................613
FAST IMPEDANCE ANALYSIS IN HIPSC-
DERIVED CARDIOMYOCYTES FOR EARLY
IDENTIFICATION OF CARDIAC DRUG
LIABILITY. ​L. Guo 1 , R. Abramas 1 , T. Singer 2 ,
T. Weiser 1,2 , J. Babiarz 1 , E. Chiao 1 and K. Kolaja 1 .
1
NCS Early & Investigative Safety, F. Hoffmann-La
Roche, Inc., Nutley, NJ and 2 Nonclinical Safety, F.
Hoffmann–La Roche Ltd., Basel, Switzerland.
#1166 Poster Board Number.....................................614
VARDENAFIL INCREASES THE BEAT
RATE OF HUMAN CARDIOMYOCYTES
VIA POTENTIATION OF HCN4 CHANNEL
CURRENTS. ​A. Bruening-Wright, Y. A. Kuryshev,
J. W. Kramer, A. MacCormack, T. Yang, W. Pei and
A. M. Brown. ChanTest Corp., Cleveland, OH.
#1167 Poster Board Number.....................................615
GENERATION AND VALIDATION OF
CELL BASED REPORTER SYSTEM TO
MONITOR EPIGENETIC CHANGES IN
HUMAN EMBRYONIC AND INDUCED
PLURIPOTENT STEM CELLS. ​I. Gurevich,
W. Krueger and T. P. Rasmussen. Pharmaceutical
Sciences, University of Connecticut, Storrs, CT.
#1168 Poster Board Number.....................................616
DIFFERENTIAL PAH EFFECTS MEDIATED
BY CYP1A1 AND CYP1B1 IN THE BONE
MARROW SPECIFICALLY TARGET
HEMATOPOIETIC PROGENITORS. ​M. L.
Larsen 1 , A. U. N’Jai 3 , C. J. Czuprynski 3,2 and C. R.
Jefcoate 1,2 . 1 Pharmacology, University of Wisconsin,
Madison, WI, 2 Molecular and Environmental
Toxicology Center, University of Wisconsin,
Madison, WI and 3 School of Veterinary Medicine,
University of Wisconsin, Madison, WI.
Tuesday
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