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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # Tuesday Morning, March 8 9:00 AM to 12:30 PM Exhibit Hall Poster Session: ImmunoSafety Methods in Non-Rodents Chairperson(s): Melissa Rhodes, GlaxoSmithKline, Research Triangle Park, NC. Displayed: 9:00 AM–12:30 PM Author Attended: 11:00 AM–12:30 PM #1140 Poster Board Number.....................................522 VALIDATION OF AN IN VITRO SCREENING METHOD FOR THE INDUCTION OF DRUG CYTOKINE RELEASE IN CYNOMOLGUS MONKEY. M. S. Piché, S. Lavallée, S. Legris, R. Falvo, K. Eliacin and L. LeSauteur. Immunology, Charles River Preclinical Services, Montréal, QC, Canada. #1141 Poster Board Number.....................................523 EVALUATING THE SECONDARY IMMUNE RESPONSE TO KLH IN CYNOMOLGUS MACAQUES: AN EX VIVO APPROACH. S. H. Cole, P. Gorman, T. T. Kawabata, M. Collinge and S. Casinghino. Immunotoxicology, Pfizer Global R&D, Groton, CT. #1142 Poster Board Number.....................................524 DEVELOPMENT OF AN ASSAY TO MEASURE NATURAL KILLER CELL FUNCTION IN CYNOMOLGUS MACAQUES. S. Haskett, C. Donovan, C. Thiffeault, T. Kawabata and C. Kamperschroer. Pfizer, Groton, CT. #1143 Poster Board Number.....................................525 FLOW CYTOMETRY AND REPORTABLE COMBINATIONS: WHEN IS ENOUGH TRULY ENOUGH? A. R. Mcintyre, T. Salewsky, T. Warren, C. Cornwall, N. Pratt, R. Eyre and H. Tsusaki. SNBL USA, Ltd., Everett, WA. #1144 Poster Board Number.....................................526 QUALIFCATION OF FLOW CYTOMETRY IMMUNOPHENOTYPING FOR Preclinical APPLICATIONS IN NON-HUMAN PRIMATES. T. Salewsky, A. R. Mcintyre, T. Warren, A. Charzynska, N. Clark, R. Eyre and H. Tsusaki. SNBL USA, Ltd., Everett, WA. #1145 Poster Board Number.....................................527 DELAYED-TYPE HYPERSENSITIVITY (DTH) REACTION WITH TETANUS TOXOID (TTX) IN CYNOMOLGUS MONKEYS. Y. Takahashi, Y. Otsubo, K. Nagatomo, T. Nakamura, T. Sukamoto, K. Fukuzaki and R. Nagata. Shin Nippon Biomedical Laboratories (SNBL), Ltd., Kagoshima, Japan. #1146 Poster Board Number.....................................528 IMMUNOTOXICITY ASSESSMENT IN INFANT CYNOMOLGUS MONKEYS BY MEASUREMENT OF HUMORAL IMMUNITY (TDAR) TO KLH AND INNATE IMMUNITY (NATURAL KILLER (NK) CELL ACTIVITY). F. G. Burleson 1 , N. Makori 2 , N. Lalayeva 2 , G. R. Burleson 1 and H. Tsusaki 2 . 1 BRT-Burleson Research Technologies, Inc., Morrisville, NC and 2 SNBL, Everett, WA. #1147 Poster Board Number.....................................529 REPRODUCTIVE TOXICOLOGY AND INFANT IMMUNOPHENOTYPING: REFERENCE RANGES FOR T-CELL ASSESSMENT IN INFANTS. C. Cornwall, A. R. Mcintyre, T. Salewsky, T. Warren, N. Pratt, R. Eyre and H. Tsusaki. SNBL USA, Ltd., Everett, WA. #1148 Poster Board Number.....................................530 DEVELOPMENT OF AN ASSAY TO DETECT CMV AND LCV SPECIFIC T-CELLS TO EVALUATE IMMUNE STATUS IN CYNOMOLOGUS MONKEYS. P. A. Schneider, L. O’Donnell, T. T. Kawabata and C. Kamperschroer. Pfizer, Groton, CT. #1149 Poster Board Number.....................................531 VIRAL LOAD AND LYTIC GENE EXPRESSION ASSAYS TO DETECT REACTIVATION OF LCV IN CYNOMOLGUS MACAQUES. K. R. Tartaro 1 , S. W. Kumpf 2 , T. T. Kawabata 1 and C. Kamperschroer 1 . 1 Immunotoxicology, Pfizer, Groton, CT and 2 DART, Pfizer, Groton, CT. #1150 Poster Board Number.....................................532 IMMUNOGENICITY TESTING OF INFLIXIMAB (REMICADE®) AND ADALIMUMAB (HUMERA®) IN GOTTINGEN MINIPIGS®. G. J. van Mierlo 1 , A. H. Penninks 1 , J. Wolthoorn 1 , N. H. Cnubben 1 , L. Aarden 2 and D. Wouters 2 . 1 Toxicology and Applied Pharmacology, TNO-Quality of Life, Zeist, Netherlands and 2 Sanquin Research, Amsterdam, Netherlands. Sponsor: R. Woutersen. #1151 Poster Board Number.....................................533 IMMUNOGENICITY TESTING OF KINERET® IN GOTTINGEN MINIPIGS®. A. H. Penninks 1 , J. Wolthoorn 2 , N. H. Cnubben 1 and G. J. van Mierlo 1 . 1 Toxicology and Applied Pharmacology, TNO-Quality of Life, Zeist, Netherlands and 2 Analytical Research, TNO Quality of Life, Zeist, Netherlands. Sponsor: R. Woutersen. #1152 Poster Board Number.....................................534 ASSESSMENT OF IMMUNE FUNCTION IN CELLS ISOLATED FROM BRONCHOALVELOAR LAVAGE (BAL) FLUID, OBTAINED IN-LIFE IN THE DOG. V. Leighton, A. Head, G. Hale and S. A. Kirk. Covance Laboratories Ltd., Harrogate, United Kingdom. Tuesday Morning, March 8 9:00 AM to 12:30 PM Exhibit Hall Poster Session: Stem Cell Toxicology Chairperson(s): Rakesh Ranjan, Bayer CropScience, Research Triangle Park, NC. Displayed: 9:00 AM–12:30 PM Author Attended: 9:00 AM–11:00 AM #1153 Poster Board Number.....................................601 TRANSIENT KNOCK DOWN OF CHK1 IN BONE MARROW HEMATOPOIETIC PROGENITORS IS LINKED TO BONE MARROW TOXICITY. B. Jessen and W. Hu. DSRD, Pfizer, San Diego, CA. 216 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1154 Poster Board Number.....................................602 RADIATION AND SENESCENCE: DECELERATION OF CELL-CYCLE IN PRIMITIVE HEMOPOIETIC PROGENITORS (CFU-S13) WAS ONLY SIGNIFICANT PARAMETER DURING AGING, WHICH WAS REACTIVELY ACCELERATED AFTER 2GY WHOLE-BODY IRRADIATION. Y. Hirabayashi 1 , I. Tsuboi 2 , K. Sekita 1 , J. Kanno 1 , Y. Kusunoki 3 and T. Inoue 1,2,3 . 1 NCBCR, NIHS, Tokyo, Japan, 2 School of Medicine, Nihon University, Tokyo, Japan and 3 RERF, Hiroshima, Japan. #1155 Poster Board Number.....................................603 CADMIUM-INDUCED TRANSFORMATION OF HUMAN STEM CELLS. E. Tokar and M. Waalkes. National Toxicology Program, NIEHS, Research Triangle Park, NC. #1156 Poster Board Number.....................................604 GROWTH HORMONE VS. PEGYLATED GH LIPOATROPHY IN HUMAN STEM CELL DERIVED ADIPOCYTES. P. M. Bartholomew 1 , C. Donahue 2 , M. Thiede 2 , S. Martin 3 and J. Vajdos 2 . 1 Drug Safety R&D, Pfizer Inc., Groton, CT, 2 Genetically Modified Models, Pfizer Inc., Groton, CT and 3 Pharm R&D, Pfizer Inc., Groton, CT. #1157 Poster Board Number.....................................605 DIOXIN, A POTENT LIGAND OF THE ARYL HYDROCARBON RECEPTOR, ALTERS MIGRATION OF MURINE HEMATOPOIETIC STEM CELLS. F. L. Casado-Pena, K. P. Singh and T. A. Gasiewicz. Environmental Medicine, University of Rochester, Rochester, NY. #1158 Poster Board Number.....................................606 ARYL HYDROCARBON RECEPTOR AGONIST DIOXIN PRODUCES ALTERATIONS IN EARLY HEMATOPOIESIS IN MOUSE FETAL LIVER. K. P. Singh, F. L. Casado and T. A. Gasiewicz. Environmental Medicine, University of Rochester Medical Center, Rochester, NY. #1159 Poster Board Number.....................................607 INVOLVEMENT OF AMPK IN SUNITINIB MEDIATED CARDIOTOXICITY IN HUMAN STEM CELL DERIVED CARDIOMYOCYTES. J. D. Cohen, S. Kameoka, J. Babiarz, T. Weiser, T. Singer and K. Kolaja. Nonclinical Safety, Hoffmann-La Roche, Nutley, NJ. #1160 Poster Board Number.....................................608 HYPOTHERMOSOL—DERISKING A VEHICLE. C. Potter 1 , K. Hedley 1 , M. Sharpe 1 , P. Cleall 1 , A. Raber 2 , W. Vant Hof 2 , R. Deans 2 and A. Mathew 3 . 1 Pfizer, Sandwich, Kent, United Kingdom, 2 AtherSys, Cleveland, OH and 3 Biolife Solutions, Bothell, WA. #1161 Poster Board Number.....................................609 CARDIAC TROPONIN I AS A MARKER OF CARDIOTOXICITY IN HUMAN- INDUCED PLURIPOTENT STEM CELL CARDIOMYOCYTES. R. Abrams 1 , M. Dunn 1 , D. Coluccio 1 , G. Hirkaler 1 , J. Babiarz 1 , R. Nicklaus 1 , W. Geng 1 , I. Mikaelian 1 , T. Singer 2 and K. Kolaja 1 . 1 Nonclinical Safety, Roche, Nutley, NJ and 2 Nonclinical Safety, Roche, Basel, Switzerland. Abstract # #1162 Poster Board Number.....................................610 IN VITRO TOXICITY OF (THIO)ARSENATES FOR HUMAN UROTHELIAL CELLS (UROTSA) AND HEPATOCYTES (HEPG2). S. Rabieh 1 , R. Lohmayer 1 , S. Hinrichsen 1 , E. Dopp 2 and B. Planer–Friedrich 1 . 1 Environmental Geochemistry, University of Bayreuth, Bayreuth, Germany and 2 Institute of Hygiene and Occupational Medicine, University Hospital Essen, Essen, Germany. #1163 Poster Board Number.....................................611 THE MRNA AND MIRNA PROFILE OF HUMAN IPS-CELLS DIFFERENTIATING TO CARDIOMYOCYTES. J. Babiarz 1 , M. Ravone 2 , B. Anson 3 , C. Kendrick-Parker 3 , E. Nuywasir 3 , T. Weiser 2 , T. Singer 2 , E. Chiao 1 , U. Certa 2 and K. Kolaja 1 . 1 Nonclinical Safety, F. Hoffman-La Roche, Nutley, NJ, 2 Nonclinical Safety, F. Hoffman-La Roche, Basel, Switzerland and 3 Cellular Dynamics International, Madison, WI. #1164 Poster Board Number.....................................612 USE OF INDUCED PLURIPOTENT CELL-DERIVED CARDIOMYOCYTES TO PREDICT AND INVESTIGATE DRUG- INDUCED CARDIAC INJURY. S. Kameoka 1 , J. Babiarz 1 , B. Anson 3 , C. Kendrick-Parker 3 , E. Nuwaysir 3 , T. Weiser 2 , T. Singer 2 , E. Chiao 1 and K. Kolaja 1 . 1 Nonclinical Safety, F. Hoffman-La Roche, Nutley, NJ, 2 Nonclinical Safety, F. Hoffman-La Roche, Basel, Switzerland and 3 Cellular Dynamics International, Madison, WI. #1165 Poster Board Number.....................................613 FAST IMPEDANCE ANALYSIS IN HIPSC- DERIVED CARDIOMYOCYTES FOR EARLY IDENTIFICATION OF CARDIAC DRUG LIABILITY. L. Guo 1 , R. Abramas 1 , T. Singer 2 , T. Weiser 1,2 , J. Babiarz 1 , E. Chiao 1 and K. Kolaja 1 . 1 NCS Early & Investigative Safety, F. Hoffmann-La Roche, Inc., Nutley, NJ and 2 Nonclinical Safety, F. Hoffmann–La Roche Ltd., Basel, Switzerland. #1166 Poster Board Number.....................................614 VARDENAFIL INCREASES THE BEAT RATE OF HUMAN CARDIOMYOCYTES VIA POTENTIATION OF HCN4 CHANNEL CURRENTS. A. Bruening-Wright, Y. A. Kuryshev, J. W. Kramer, A. MacCormack, T. Yang, W. Pei and A. M. Brown. ChanTest Corp., Cleveland, OH. #1167 Poster Board Number.....................................615 GENERATION AND VALIDATION OF CELL BASED REPORTER SYSTEM TO MONITOR EPIGENETIC CHANGES IN HUMAN EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLS. I. Gurevich, W. Krueger and T. P. Rasmussen. Pharmaceutical Sciences, University of Connecticut, Storrs, CT. #1168 Poster Board Number.....................................616 DIFFERENTIAL PAH EFFECTS MEDIATED BY CYP1A1 AND CYP1B1 IN THE BONE MARROW SPECIFICALLY TARGET HEMATOPOIETIC PROGENITORS. M. L. Larsen 1 , A. U. N’Jai 3 , C. J. Czuprynski 3,2 and C. R. Jefcoate 1,2 . 1 Pharmacology, University of Wisconsin, Madison, WI, 2 Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI and 3 School of Veterinary Medicine, University of Wisconsin, Madison, WI. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 217
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Program
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 Abstract
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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Society of Toxicology 2011 SOT Affi
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