Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
#449 Poster Board Number.....................................134
THE ALPHA MUPA MICE, A MODEL OF
CALORIC RESTRICTION, ARE MORE
SUSCEPTIBLE TO ACETAMINOPHEN
HEPATOTOXICITY. ​Z. Fu 1 , Y. Zhang 1 , R. Miskin 2
and C. D. Klaassen 1 . 1 Department of Pharmacology,
Toxicology and Therapeutics, University of Kansas
Medical Center, Kansas City, KS and 2 Department
of Biological Chemistry, The Weizmann Institute of
Science, Rehovot, Israel.
#450 Poster Board Number.....................................135
ACTIVATION OF CASPASES DURING
ACETAMINOPHEN TOXICITY IS A STRAIN
DEPENDENT PHENOMENON. ​H. Jaeschke,
M. Koerner and C. D. Williams. University of Kansas
Medical Center, Kansas City, KS.
#451 Poster Board Number.....................................136
INHIBITION OF THE MITOCHONDRIAL
MEMBRANE PERMEABILITY
TRANSITION PORE PROTECTS
AGAINST ACETAMINOPHEN-INDUCED
MITOCHONDRIAL OXIDANT STRESS AND
LIVER INJURY IN VIVO. ​A. Ramachandran 1 ,
M. Lebofsky 1 , C. Baines 2 , S. A. Weinman 1 , J. J.
Lemasters 3 and H. Jaeschke 1 . 1 Pharmacology,
Toxicology & Therapeutics, University of Kansas
Medical Center, Kansas City, KS, 2 University of
Missouri, Columbia, MO and 3 Medical University of
South Carolina, Charleston, SC.
#452 Poster Board Number.....................................137
ROLE OF THE NALP3 INFLAMMASOME
IN NEUTROPHIL ACTIVATION AND CELL
INJURY DURING ACETAMINOPHEN-
INDUCED HEPATOTOXICITY. ​C. D.
Williams 1 , P. J. Shaw 2 and H. Jaeschke 1 . 1 University
of Kansas Medical Center, Kansas City, KS and
2
New York University, New York, NY.
#453 Poster Board Number.....................................138
ACETAMINOPHEN HEPATOTOXICITY
IN HUMANS: MITOCHONDRIAL
INJURY AND DNA FRAGMENTATION IN
OVERDOSE PATIENTS. ​M. R. McGill 1 , M. R.
Sharpe 2 , C. Williams 1 , M. Taha 2 and H. Jaeschke 1 .
1
Pharmacology, Toxicology, and Therapeutics,
University of Kansas Medical Center, Kansas City,
KS and 2 Internal Medicine, University of Kansas
Medical Center, Kansas City, KS.
#454 Poster Board Number.....................................139
KAVA EXTRACT, AN HERBAL
ALTERNATIVE FOR ANXIETY RELIEF,
POTENTIATES ACETAMINOPHEN-
INDUCED CYTOTOXICITY IN RAT
HEPATIC CELLS. ​X. Yang and W. F. Salminen.
Division of Systems Biology, U.S. FDA, NCTR,
Jefferson, AR.
#455 Poster Board Number.....................................140
HEPATIC ENDOTHELIAL CELLS
REGULATE LIVER CELL REPAIR
FOLLOWING ACETAMINOPHEN
INTOXICATION. ​Y. Liu, C. R. Gardner, M.
Francis, J. D. Laskin and D. L. Laskin. Pharmacology
& Toxicology, Rutgers University, Piscataway, NJ.
#456 Poster Board Number.....................................141
NEGATIVE REGULATION OF CLASSICAL
MACROPHAGE ACTIVATION BY THE STK
RECEPTOR DURING ACETAMINOPHEN-
INDUCED HEPATOTOXICITY. ​C. R.
Gardner 1 , Y. Liu 1 , P. A. Hankey 2 , J. D. Laskin 3 and
D. L. Laskin 1 . 1 Rutgers University, Piscataway, NJ,
2
Pennsylvania State University, University Park, PA
and 3 UMDNJ-Robert Wood Johnson Medical School,
Piscataway, NJ.
#457 Poster Board Number.....................................142
ROLE OF MACROPHAGE-DERIVED
GALECTIN-3 IN ACETAMINOPHEN-
INDUCED HEPATOTOXICITY. ​A. Dragomir 1 ,
R. Sun 1 , J. D. Laskin 2 and D. L. Laskin 1 .
1
Pharmacology and Toxicology, Rutgers University,
Piscataway, NJ and 2 Environmental and Occupational
Medicine, UMDNJ-Robert Wood Johnson Medical
School, Piscataway, NJ.
#458 Poster Board Number.....................................143
TARGETING OF THIOREDOXIN
REDUCTASE BY THE ACETAMINOPHEN
METABOLITE N-ACETYL-P-
BENZOQUINONE IMINE. ​Y. Jan 1 , D. E. Heck 2 ,
D. L. Laskin 3 , Y. Liu 3 , A. Dragomir 3 and J. D.
Laskin 1 . 1 Environmental & Occupational Medicine,
UMDNJ-Robert Wood Johnson Medical School,
Piscataway, NJ, 2 Environmental Health, New York
Medical College, Valhalla, NY and 3 Pharmacology &
Toxicology, Rutgers University, Piscataway, NJ.
#459 Poster Board Number.....................................144
TRIFLUOPERAZINE MEDIATED
HEPATOPROTECTION AND REDUCTION
OF HIF-1α IN ACETAMINOPHEN
MEDIATED TOXICITY IN MICE. ​S.
Chaudhuri 1 , S. S. McCullough 1 , A. Brown 1 ,
J. A. Hinson 2 and L. P. James 1,2 . 1 Pediatrics/
Clinical Pharmacology, Arkansas Childrens
Hospital Research Institute, Little Rock, AR and
2
Pharmacology and Toxicology, University of
Arkansas for Medical Sciences, Little Rock, AR.
#460 Poster Board Number.....................................145
SULFORAPHANE PREVENTS
ACETAMINOPHEN-INDUCED HEPATIC
INJURY IN MICE. ​R. Schmidt 1,2 , K. C. Falkner 2,3 ,
J. Beier 1,2 and G. Arteel 1,2 . 1 Pharmacology &
Toxicology, University of Louisville, Louisville, KY,
2
Alcohol Research Center, University of Louisville,
Louisville, KY and 3 Medicine, University of
Louisville, Louisville, KY. Sponsor: C. States.
#461 Poster Board Number.....................................146
ACETAMINOPHEN (APAP) AND
S-ADENOSYL-L-METHIONINE (SAME)
EFFECTS ON OXIDATIVE STRESS
ENZYMES: ATTENUATION BY SAME. ​J.
Brown, J. G. Ball, T. Ahmad and M. Valentovic.
Pharmacology, Physiology, and Toxicology, Marshall
University School of Medicine, Huntington, WV.
#462 Poster Board Number.....................................147
NERVE GROWTH FACTOR (NGF) IN
MOUSE LIVER HAS AN AUTOCRINE
ACTIVITY AND ITS TRANSCRIPTION IS
MODULATED BY BSO, ACETAMINOPHEN,
AND ARSENIC. ​C. Valdovinos and M. E.
Gonsebatt. Instituto de Investigaciones Biomedicas,
Universidad Nacional Autónoma de México, Mexico,
D.F., Mexico.
156
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