Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Abstract # Abstract # MONday Monday Afternoon, March 7 4:45 PM to 5:45 PM E-mail Center, East Salon (Access on-site in the E-mail Center or via your Internet connection) 50th Anniversary Silent Auction Chairperson(s): Anne Loccisano, The Hamner Institutes for Health Sciences, Research Triangle Park, NC. In honor of the 50th Anniversary of SOT, the Postdoctoral Assembly is organizing the 50th Anniversary Silent Auction. Bid on vacation get-aways or purchase items of historical significance to SOT and toxicology (such as books, laboratory items, memorabilia, photographs) as well as other items of general interest. Bids for some items will close in the E-mail Center Monday, March 7, from 4:45 PM–5:45 PM. Join the excitement! Cash bar available. Bring your laptop or smart phone to join in the bidding. Bids for remaining items will close beginning at 10:00 AM Wednesday and conclude at 1:00 PM. All proceeds from the Silent Auction will go to the Endowment Priorities Fund. Monday Evening, March 7 5:30 PM to 7:30 PM Embassy Suites Capital Ballroom A Regional Chapter Joint Reception: National Capital Area/ NRC Committee on Toxicology Monday Evening, March 7 6:00 PM to 7:30 PM RFD Restaurant Regional Chapter Joint Reception: Mountain West/Southern California Monday Evening, March 7 6:00 PM to 8:00 PM Renaissance Grand Ballroom South Special Interest Group Meeting/Reception: American Association of Chinese in Toxicology Monday Evening, March 7 5:00 PM to 7:00 PM Fado Irish Pub Monday Evening Monday Evening, March 7 5:00 PM to 6:00 PM Renaissance Grand Ballroom South AACT Distinguished Chinese Toxicologist Lectureship: Oxidative Stress and Metal Carcinogenesis Regional Chapter Joint Reception: Gulf Coast/South Central Monday Evening, March 7 5:00 PM to 6:00 PM (Buses Depart CC from L Street beginning at 4:00 PM) Capital Hill, Russell Senate Building Specialty Section Meeting/Reception: Regulatory and Safety Evaluation—The Great Debate—Hazard Information Provides an Adequate Basis for Restricting Chemical Use Moderator: James Lamb Debaters: George Gray and Lorenz Rhomberg Honorary Host: Senator Johnny Isakson (R-GA) The reception and debate will take place on Capitol Hill in Suite 325, the Kennedy Caucus Room, of the Russell Senate Office Building. Space is limited and attendance is on a first come first served basis. Buses depart for the event beginning at 4:00 PM at the L Street entrance of the Convention Center. Guests must have valid photo identification. Please wear your SOT Annual Meeting badge to gain entrance. Monday Evening, March 7 6:00 PM to 7:30 PM Salon H Special Interest Group Meeting/Reception: Association of Scientists of Indian Origin in America Monday Evening, March 7 6:00 PM to 8:00 PM Embassy Suites Capital Ballroom B Special Interest Group Meeting/Reception: Toxicologists of African Origin Monday Evening, March 7 6:00 PM to 7:30 PM See room listings below. Specialty Section Meeting/Reception: Biotechnology (Room 140B), Cardiovascular Toxicology (Room 102), Molecular Biology (Room 159), Neurotoxicology (Salon G), Risk Assessment (Salon I), Stem Cells Inaugural (Room 149) Monday Evening, March 7 6:30 PM to 8:30 PM District Chophouse Restaurant Regional Chapter Reception: Northern California Monday Evening, March 7 6:30 PM to 8:30 PM Renaissance Meeting Room 10 Special Interest Group Meeting/Reception: Korean Toxicologists Association in America 192 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # Tuesday Morning, March 8 6:30 AM to 7:50 AM Room 144 Tuesday Morning Roundtable Session: Current Uses and Understanding of the Tissue Cross Reactivity Assay Chairperson(s): Jeanine Bussiere, Amgen, Inc., Thousand Oaks, CA, and Michael Leach, Pfizer, Andover, MA. Sponsor: Biotechnology Specialty Section Endorsed by: Toxicologic and Exploratory Pathology Specialty Section Tissue cross-reactivity (TCR) studies are screening assays conducted with monoclonal antibodies and related antibody-like biopharmaceuticals primarily to identify off-target binding, and secondarily to identify sites of on-target binding that were not previously identified. As presently utilized by the biopharmaceutical industry and regulatory agencies, TCR studies usually involve the ex vivo immunohistochemical (IHC) staining of a panel of frozen tissues from humans and animals. However, other methods of conducting TCR studies are possible. While ex vivo TCR studies have become routine in the development of antibody therapeutics, their value for the purpose of making safety assessment decisions by both industry and regulatory agencies has been questioned as experience with the assay has increased. Recently, an industry white paper was published to review the use of tissue cross-reactivity studies in the development of antibody-based biopharmaceuticals: history, experience, methodology, and future directions. In addition, a multinational pharmaceutical and biotechnology company survey was conducted to gain a better understanding of the use and value of the TCR assay in the development of biotherapeutic molecules. The information from this survey can be used to help understand the appropriate use and interpretation of this assay in a nonclinical drug development program. Our panel of experts will address the following issues of importance including how we got to where we are today; the technical aspects of the TCR assay and issues with interpretation; case studies and summary from white paper on use of TCR; industry survey results on use of the TCR assay; and, the new technologies for identifying off-target binding of monoclonal antibodies. #881 6:30 CURRENT USES AND UNDERSTANDING OF THE TISSUE CROSS REACTIVITY ASSAY. J. L. Bussiere 1 , J. Cavagnaro 5 , E. Galbreath 3 , T. Machlachlan 6 , N. Dybdal 4 and M. Leach 2 . 1 Toxicology, Amgen, Inc., Thousand Oaks, CA, 2 Drug Safety Research and Development, Pfizer, Andover, MA, 3 Toxicology, Lilly Research Laboratories, Indianapolis, IN, 4 Safety Assessment, Genentech, Inc., South San Francisco, CA, 5 AccessBio, Boyce, VA and 6 Pharmacology and Toxicology, Genzyme, Framingham, MA. 6:30 TCR: HOW WE GOT TO WHERE WE ARE TODAY. Joy Cavagnaro 6:45 TECHNICAL ASPECTS OF THE TCR ASSAY AND ISSUES WITH INTERPRETATION. Elizabeth Galbreath 7:00 CASE STUDIES AND SUMMARY FROM THE WHITE PAPER ON USE OF TCR. Tim MacLachlan 7:15 INDUSTRY SURVEY RESULTS ON USE OF THE TCR ASSAY. Jeanine L. Bussiere 7:30 PANEL DISCUSSION/Q&A. Abstract # Tuesday Morning, March 8 6:30 AM to 7:50 AM Room 143 Emerging Global Public Health Issues Roundtable Session: Risk and Risk Management of Potentially Toxic Compounds Formed by Cooking Food Chairperson(s): Steven Hermansky, ConAgra Foods, Inc., Omaha, NE, and Wu Li, Frito-Lay, Inc., Plano, TX. Sponsor: Food Safety Specialty Section Endorsed by: Regulatory and Safety Evaluation Specialty Section Risk Assessment Specialty Section The discovery of acrylamide in food in 2002 by Swedish researchers initiated an international effort to assess exposure and manage risk to the public. Millions of dollars and countless hours of resources have been dedicated to this effort around the world. The concept that cooking changes the chemistry of food is not new but the presence of acrylamide across a wide variety of foods brought a new perspective to food safety for the international regulatory community. This issue continues to develop as different research groups focus on multiple heat-formed chemicals and various aspects of toxicology of these naturally occurring compounds. From the recent completion of the European Union HEATOX (Heat-Generated Food Toxicants: Identification, Characterization, and Risk Minimization) project to the development of increasingly sensitive and refined analytical methods that are able to detect ever lower concentrations of compounds in foods, it is becoming increasingly clear that acrylamide only represents one compound of many. This revelation presents challenges to both the scientific and regulatory communities. Just as importantly, resources are more frequently stretched thin as scientific debates are played out in the mass media and the credibility of the scientific and regulatory process is challenged. We will discuss the challenges and opportunities presented by risk management of compounds formed in food during cooking. #882 6:30 RISK AND RISK MANAGEMENT OF POTENTIALLY TOXIC COMPOUNDS FORMED BY COOKING FOOD. S. J. Hermansky 1 , W. Li 8 , R. Lane 2 , N. Rachman 4 , S. Olin 5 , T. Troxell 3 , M. Bolger 6 and A. Tritscher 7 . 1 ConAgra Foods, Omaha, NE, 2 Pepsico, Valhalla, NY, 3 Exponent, Washington, D.C., 4 Grocery Manufacturer’s Association, Washington, D.C., 5 ILSI Research Foundation, Washington, D.C., 6 U.S. FDA Center for Food Safety and Nutrition, Washington, D.C., 7 World Health Organization, Geneva, Switzerland and 8 Frito Lay, Plano, TX. 6:30 INTRODUCTORY REMARKS AND SUMMARY OF NEW DATA. Steven J. Hermansky 6:35 THE POLITICS OF CHEMICAL FOOD SAFETY. Richard Lane 6:47 THE NEW FOOD LANDSCAPE: BALANCING THE BENEFITS WITH THE CHEMICAL RISKS OF COOKING. Nancy J. Rachman 6:59 EVALUATING THE TOXICOLOGY OF CHEMICALS IN FOOD: DO WE NEED A NEW PARADIGM? Steve S. Olin 7:11 ESTABLISHING A FUTURE RISK MANAGEMENT VISION FOR COOKING TOXINS. Terry Troxell 7:23 PANEL DISCUSSION. Mike Bolger and Angelika Tritscher Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 193
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Toxicological Sciences The Official
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 2010-201
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