Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
Tuesday
Abstract # Abstract #
Tuesday Morning, March 8
9:00 AM to 11:45 AM
Room 204
Platform Session: Computational Approaches to Address
DILI and Hepatoxicity
Chairperson(s): Amy Wang, U.S. Environmental Protection Agency,
Research Triangle Park, NC, and Raymond Kemper, Boehringer
Ingelheim Pharmaceuticals, Ridgefield, CT.
#934 9:00 THE FDA’S LIVER TOXICITY
KNOWLEDGE BASE (LTKB) PROJECT. ​W.
Tong 1 , M. Chen 1 , V. Vikrant 1 , Q. Shi 1 , M. Zhang 1 , L.
Guo 2 , Z. Liu 1 , J. Zhang 1 and E. Bearden 1 . 1 Division
of Systems Biology, U.S. FDA NCTR, Jefferson, AR
and 2 Division of Biochemical Toxicology, U.S. FDA
NCTR, Jefferson, AR.
#935 9:21 VALIDATION OF CELLCIPHR
CELLULAR SYSTEMS BIOLOGY (CSB)
TECHNOLOGY. CELLCIPHR2—
BUILDING ON EXPERIENCE OF IN VIVO
RAT LIVER INJURY PREDICTION TO
DEVELOP THE HUMAN DILI PREDICTION. ​
S. Thomas 2 , J. Mein 2 , R. Annand 1 , P. Walker 2 , M.
Jacewicz 1 , D. Steen 3 , C. Chesne 3 , J. Gilbert 1,2 and K.
Tsaioun 1,2 . 1 Apredica, Watertown, MA, 2 Cyprotex,
Macclesfield, United Kingdom and 3 Biopredic,
Rennes, France.
#936 9:42 INVESTIGATING THE ROLE OF
MITOCHONDRIAL TOXICITY IN DRUG-
INDUCED LIVER INJURY VIA CONGRUENT
STRUCTURE-ACTIVITY RELATIONSHIPS. ​
M. L. Patel 1 , L. Fisk 1 , N. Greene 2 and R. T. Naven 2 .
1
Lhasa Limited, Leeds, United Kingdom and
2
Worldwide Medicinal Chemistry, Pfizer Inc.,
Groton, CT.
#937 10:03 QUANTITATIVE SIMULATION OF
INTRACELLULAR SIGNALING CASCADES
IN A VIRTUAL LIVER: ESTIMATING
DOSE DEPENDENT CHANGES IN
HEPATOCELLULAR PROLIFERATION
AND APOPTOSIS. ​J. Jack 1 , M. Mennecozzi 2 , C.
Haugh 1 , J. Wambaugh 1 and I. Shah 1 . 1 National Center
for Computational Toxicology, U.S. EPA, Research
Triangle Park, NC and 2 Joint Research Centre,
European Commission, Ispra, Italy.
#938 10:24 PHYSIOLOGICALLY BASED
PHARMACOKINETIC (PBPK)
MODELING TO PREDICT PLASMA
PHARMACOKINETICS FOR LIVER
TRANSPORTER SUBSTRATES. ​H. A.
Barton 1 , H. Jones 2 and Y. Lai 1 . 1 Pharmacokinetics,
Pharmacodynamics, and Metabolism, Pfizer,
Inc., Groton, CT and 2 Pharmacokinetics,
Pharmacodynamics, and Metabolism, Pfizer, Inc.,
Sandwich, United Kingdom.
#939 10:45 A NOVEL PREDICTIVE PLATFORM FOR
DILI: A COMBINATION OF IN SILICO
AND IN VITRO METHODS TO PREDICT
TOXICITY MECHANISMS IN VIVO. ​S. Das,
R. Kumar, S. Raghavan and K. Subramanian. Strand
Life Sciences, Bangalore, India.
#940 11:05 APPLICATIONS OF A COMPUTATIONAL
MODEL FOR PREDICTING DRUG-
INDUCED LIVER INJURY (DILI). ​B. A.
Howell 1 , R. Kumar 3 , L. Wennerberg 3 , Y. Yang 2 , R.
Ho 3 , A. Harrill 1 , C. L. Kurtz 1 , M. E. Andersen 2 , H. J.
Clewell 2 , S. Q. Siler 3 and P. B. Watkins 1 . 1 Drug Safety
Sciences, The Hamner Institutes, Research Triangle
Park, NC, 2 Chemical Safety Sciences, The Hamner
Institutes, Research Triangle Park, NC and 3 Entelos,
Inc., Foster City, CA.
#941 11:25 DEVELOPMENT OF A PBPK/PD MODEL
FOR ACETAMINOPHEN TOXICITY IN
RATS. ​Y. Yang, B. Howell, M. Yoon, M. Andersen
and H. J. Clewell. The Hamner Institutes for Health
Sciences, Research Triangle Park, NC.
Tuesday Morning, March 8
9:00 AM to 11:45 AM
Room 201
Epigenetic Mechanisms
Platform Session: Epigenetic Mechanisms in Development
and Disease
Chairperson(s): Yanan Tian, Texas A&M University, College Station, TX,
and Xiefan Fang, University of Mississippi, University, MS.
#942 9:00 USING ZEBRAFISH TO STUDY BENZO(A)
PYRENE-MEDIATED CHANGES IN
DNA METHYLATION STATUS DURING
DEVELOPMENT. ​X. Fang 1 , C. Thornton 1 , B.
E. Scheffler 2 and K. L. Willett 1 . 1 Department of
Pharmacology and Toxicology, the University of
Mississippi, University, MS and 2 Genomics and
Bioinformatics Research Unit, USDA Mid South
Area Genomics Laboratory, Stoneville, MS.
#943 9:19 GENOME-WIDE DNA METHYLATION
DIFFERENCES BETWEEN LATE-
ONSET ALZHEIMER’S DISEASE AND
COGNITIVELY NORMAL CONTROLS
IN THE HUMAN FRONTAL CORTEX. ​K.
Bakulski 1 , D. C. Dolinoy 1 , M. A. Sartor 1 , H. L.
Paulson 2 , A. P. Lieberman 2 , R. L. Albin 2 , H. Hu 1,2 and
L. S. Rozek 2 . 1 School of Public Health, University
of Michigan, Ann Arbor, MI and 2 Medical School,
University of Michigan, Ann Arbor, MI.
#944 9:38 EPIGENETIC CHANGES DURING
CO-CARCINOGENESIS OF N,
N-DIETHYLNITROSAMINE AND CARBON
TETRACHLORIDE IN MOUSE LIVER. ​K.
Kutanzi 1 , I. Koturbash 1 , T. Uehara 2 , O. Kosyk 2 ,
I. Pogribny 1 and I. Rusyn 2 . 1 National Center for
Toxicological Research, U.S. FDA, Jefferson, AR
and 2 Department of Environmental Sciences and
Engineering, University of North Carolina at Chapel
Hill, Chapel Hill, NC.
#945 9:57 AH RECEPTOR INHIBITS GENE
EXPRESSION OF DELETED IN LIVER
CANCER (DLC1) THROUGH REGULATION
OF MICRORNA IN MOUSE LIVER CELLS. ​
Y. Tian 1 , S. Ke 1 , M. Huang 2 , B. Zhou 1 and Z. Zhou 2 .
1
Program of Toxicology, Texas A&M University,
College Station, TX and 2 School of Public Health,
Fudan University, Shanghai, China.
200
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