Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
Monday Afternoon, March 7
12:00 NOON to 1:20 PM
Salon G
(Ticket Required)
Monday Afternoon
In Vitro Toxicology Lecture and Luncheon for
Students: Full Speed into an Alternative
Future
Lecturer: Robert E. Chapin, Pfizer, Groton, CT.
Chairperson(s): Aaron Barchowsky, University of
Pittsburgh, Pittsburgh, PA.
Sponsor:
Colgate-Palmolive Company
The purpose of this lecture is to discuss the importance of animal research
to biomedical sciences and toxicology and the ethical obligations of
the scientific community to follow the “3R’s” of animal testing (refine,
reduce, replace) whenever it is feasible.
Graduate students, undergraduates, postdoctoral scholars, and
recipients of Colgate-Palmolive awards are among the guests at the
In Vitro Toxicology Lecture and Luncheon. The goal of the In Vitro
Toxicology Lecture series is to feature important research using
in vitro and alternative techniques to study basic mechanisms and to
illustrate how these test methods benefit animal welfare by refining and
reducing animal use. Students and postdocs can reserve a ticket for the
luncheon with a $10 deposit when they register for the SOT Annual
Meeting. Lunch is served at the beginning of the event and service
concludes before the talk/main program begins. Meal service may not be
available to guests who arrive after 12:30 PM.
The “Toxicity Testing in the 21st Century” vision promulgates an
in vitro approach to safety assessment based heavily on knowing the
pathways responding in a cell and then correctly relating that to an in
vivo exposure and response to predict the likely health outcome. But we
are now much like Galileo was with our Moon: seeing the goal is many,
many times easier than actually getting there. However, given that animal
models correctly predict only 40–70% of human responses, in vitro
models won’t actually have to do that well to be better than the current in
vivo models (i.e., the bar is low). Thus, for both animal-use issues and for
correct-predictivity issues, an in vitro future is a worthy and achievable
goal. Meanwhile, there is much trial and error (and error) (and error) to
pursue.
This talk will quickly reprise an in vitro testing vision, and then put it into
an industry perspective. It will soon become clear that we’re a long way
from where we want to be. After this stage-setting, the audience will be
asked to discuss and then present their answer to a set of related questions.
Monday Afternoon, March 7
12:00 NOON to 1:00 PM
Room 103
(See page 84 for more information)
Special Interest Group Presidents and Officers Meeting
If you will be a President or a Vice President of a Special Interest Group
in 2011–2012, please make plans to attend the Special Interest Groups
Presidents and Officers meeting. The agenda for the meeting will include
an overview of the SOT Strategic Plan, SOT Headquarters administrative
support information, ToXchange, a review of 2010–2011 activities and
plans for the future.
Abstract #
Monday Afternoon, March 7
12:00 NOON to 2:00 PM
Embassy Suites, Capital Ballroom B
Regional Chapter Meeting/Luncheon: Central States
Monday Afternoon, March 7
12:00 NOON to 1:00 PM
Room 149
Specialty Section Meeting/Luncheon: Toxicologic and
Exploratory Pathology
Monday Afternoon, March 7
12:10 PM to 1:30 PM
Room 144
Roundtable Session: Reforming the Toxic Substances Control
Act (TSCA): Challenges, Opportunities, and Timing
Chairperson(s): Thomas Lewandowski, Gradient, Seattle, WA, and
Stanley Barone, U.S. EPA, Washington, D.C.
Sponsor:
Regulatory and Safety Evaluation Specialty Section
Endorsed by:
Nanotoxicology Specialty Section
Risk Assessment Specialty Section
The Toxic Substances Control Act (TSCA) of 1976 significantly changed
the regulatory landscape for chemicals in the United States. It gave the
federal government greater powers to track the introduction of new chemicals
into the consumer marketplace, provided the U.S. EPA with limited
powers to require testing of new chemicals, and allowed for case-by-case
restriction of chemicals shown to be particularly hazardous. Yet the basic
provisions of TSCA are now 35 years old, and unlike most major environmental
laws passed in the 1970s, the TSCA legal framework remains
essentially unchanged. Achieving the goals of TSCA, namely to ensure that
adequate data are available to allow assessment of the effect of chemical
substances and mixtures on health and the environment has also proven
difficult. The regulatory apparatus has been unable to cope with the large
number of chemicals requiring evaluation, has focused on new rather than
existing chemicals, has largely ignored the potential interaction of chemicals
occurring in mixtures, and has generally failed to keep up with advances
in technology. While once a model regulation for other nations, the TSCA
framework has now been superseded by chemical safety regulations adopted
by other jurisdictions (e.g., REACH). Given the dramatic changes in chemical
technology, toxicology, and risk assessment that are expected to occur
in the near future, reform of TSCA is seen as a high priority by many stakeholders.
Issues that are likely to be addressed by reform of TSCA include
the distinct toxicology and exposure scenarios posed by nanotechnology, the
possibility of basing hazard identification for the large number of chemicals
requiring assessment on mechanistic and in vitro data rather than standard
animal tests, and consideration of special population groups (not only
children but also those with genetic susceptibilities or chronic health conditions).
Reform of TSCA has the potential to greatly affect the way chemical
risks are assessed in the U.S. and may therefore have a significant impact on
the daily lives of society members.
#417 12:10 REFORMING THE TOXIC SUBSTANCES
CONTROL ACT (TSCA): CHALLENGES,
OPPORTUNITIES, AND TIMING. ​T.
Lewandowski 1 and S. Barone 2 . 1 Gradient, Seattle, WA
and 2 U.S. EPA, Washington, D.C.
12:10 TSCA:TIME FOR A CHANGE. ​Thomas
Lewandowski
MONday
Poster Sessions
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Roundtable Sessions
Symposium Sessions
Thematic Sessions
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151