Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
Wednesday
Abstract # Abstract #
#1771 9:55 EPIGENETIC INTERACTION BETWEEN
PERINATAL PBDE EXPOSURE AND
MECP2308 MUTATION THROUGH X
CHROMOSOME INACTIVATION. ​J.
LaSalle 1 , R. O. Vallero 1 , M. Golub 3 , J. K. Suarez 1 ,
R. Woods 1 , T. Ta 4 , A. George 1 , P. J. Kostyniak 5 , I.
N. Pessah 2 and R. Berman 4 . 1 Microbiology and
Immunology, University of California Davis School
of Medicine, Davis, CA, 2 Molecular Biosciences,
University of California Davis School of Veterinary
Medicine, Davis, CA, 3 Environmental Toxicology,
University of California Davis School of Medicine,
Davis, CA, 4 Neurological Surgery, University of
California Davis School of Medicine, Davis, CA and
5
Toxicology Research, State University of New York,
Buffalo, NY.
#1772 10:35 PATHOGENESIS OF CIRCUIT
DEVELOPMENT IN THE AUTISMS:
EMERGENCE OF THE GENE-
ENVIRONMENT AND THE
DEVELOPMENTAL NEUROBIOLOGY
INTERFACE. ​P. Levitt. Zilkha Neurogenetic
Institute, Keck School of Medicine of University of
Southern California, Los Angeles, CA. Sponsor: I.
Pessah.
#1773 11:15 AUTISM AND THE ENVIRONMENT:
CHALLENGES AND OPPORTUNITIES FOR
ADVANCING THE SCIENCE. ​C. Lawler.
Division of Extramural Research and Training,
NIEHS, Research Triangle Park, NC. Sponsor: I.
Pessah.
11:30 PANEL DISCUSSION/Q&A.
Wednesday Morning, March 9
9:00 AM to 11:45 AM
Room 144
Environment and Disease
Symposium Session: Gene-Environment Disease Interactions
in Fish Models of Human Disease
Chairperson(s): Michael Carvan, University of Wisconsin Milwaukee,
Milwaukee, WI, and Seth Kullman, North Carolina Sate University,
Raleigh, NC.
Sponsor:
Molecular Biology Specialty Section
Endorsed by:
Mechanisms Specialty Section
Use of alternative species for toxicity testing is a fast growing field in toxicology
and provides many distinct advantages as an adjunct to mammalian
testing. Thus, we will hightlight the use of small aquarium fish as models
to investigate mechanistic toxicity in relation to environment and disease
etiology. It is clear that much insight into human health and safety can be
gained through research involving various aquatic species. Much effort has
been put into using fish species as translational models for detailed mechanistic
investigation in cancer, aging, tissue regeneration, genetic diseases
and disorders, and stem cell biology. These findings emphasize that most
cellular, molecular, and biochemical processes are well conserved across
vertebrate groups. The use of aquatic organisms as models in biomedical
research has a rich and extensive history. Their research value is widely
appreciated, comprising a taxonomically and environmentally diverse group,
providing researchers with opportunities to investigate a wide range of
systems and processes. New contributions to the toxicology literature reflect
in part the strategic use of available resources and chronicle the advantages
inherent when these models are coupled to modern experimental approaches
in human disease. We will effectively communicate the current state of
research with small aquarium fish models in mechanistic toxicology as it
relates to molecular approaches addressing gene-environment and environmental-disease
interactions. Focus areas will include ‘omic approaches, role
of gene duplicates and polymorphic sequences in toxicity, and association of
genetic and environment factors in disease susceptibility. In conclustion, we
will provide a forum for investigators to exchange scientific information and
encourage enhancement of the utility of aquatic models for studies of human
disease.
#1774 9:00 GENE-ENVIRONMENT DISEASE
INTERACTIONS IN FISH MODELS
OF HUMAN DISEASE. ​M. J. Carvan 1 , J.
Postlethwait 2 , M. Hahn 3 , S. Kullman 4 and J.
Bronstein 5 . 1 Great Lakes WATER Institute,
Milwaukee, WI, 2 University of Oregon, Eugene,
OR, 3 Woods Hole Oceanographic Institution, Woods
Hole, MA, 4 North Carolina State University, Raleigh,
NC and 5 University of California Los Angeles, Los
Angeles, CA.
9:00 INTRODUCTION. ​Seth Kullan
#1775 9:05 SOX9, TCDD, GAR, AND DUPLICATE GENE
EVOLUTION. ​J. H. Postlethwait, A. Amores and
Y. Yan. University of Oregon, Eugene, OR. Sponsor:
S. Kullman.
#1776 9:36 GENE-ENVIRONMENT INTERACTIONS
AND DIOXIN SENSITIVITY IN NATURAL
AND LABORATORY POPULATIONS
OF FISH. ​M. E. Hahn 1 , S. I. Karchner 1 , M.
J. Jenny 3,1 , D. G. Franks 1 , A. M. Reitzel 1 , A. R.
Timme-Laragy 1 , N. Aluru 1 , D. E. Nacci 2 and M. F.
Oleksiak 4 . 1 Biology, Woods Hole Oceanographic
Institute, Woods Hole, MA, 2 NHEERL, U.S. EPA,
Narragansett, RI, 3 Biological Sciences, University
Alabama, Tuscaloosa, AL and 4 RSMAS, University
of Miami, Miami, FL.
#1777 10:07 ALTERATION OF DEVELOPMENTAL
PROGRAMS REGULATING CARTILAGE
AND BONE FORMATION IN TCDD
TREATED MEDAKA. ​S. W. Kullman 1 , W. Dong 1
and D. E. HInton 2 . 1 Environmental and Molecular
Toxicology, North Carolina State University, Raleigh,
NC and 2 Nicholas School of the Environment, Duke
University, Durham, NC.
#1778 10:38 INFLUENCE OF HUMAN GENE VARIANTS
ON THE EFFECTS OF DEVELOPMENTAL
MEHG EXPOSURE. ​M. J. Carvan 1 , R. Klingler 1
and J. Topczewski 2 . 1 School of Freshwater
Sciences, Great Lakes WATER Institute, University
of Wisconsin Milwaukee, Milwaukee, WI and
2
Children’s Memorial Research Center, Northwestern
University, Chicago, IL.
#1779 11:09 INVESTIGATING ENVIRONMENTAL
AND GENETIC RISK FACTORS OF
PARKINSON’S DISEASE USING
ZEBRAFISH. ​J. Bronstein, A. Kotagiri, S.
Prabhudesai, S. Sinha, S. Li and G. Bitan. Neurology,
University of California Los Angeles School of
Medicine, Los Angeles, CA. Sponsor: M. Carvan.
11:40 CLOSING REMARKS/SUMMARY.
274
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