Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
#221 Poster Board Number.....................................403
MOLECULAR MECHANISM OF ACTION
OF INSULIN SENSITIZING DRUG-
METFORMIN AS ANTICANCER AGENT IN
PANCREATIC CANCER. ​V. Vasanthakumari 1
and S. Safe 1,2 . 1 Veterinary Physiology &
Pharmacology, Texas A&M University, College
Station, TX and 2 Institute of Biosciences and
Technology, Houston, TX.
#222 Poster Board Number.....................................404
PHARMACOLOGICAL INHIBITION OF
THE TGFβ1 TYPE I RECEPTOR INDUCES
PREMALIGNANT KERATINOCYTE
TERMINAL DIFFERENTIATION. ​K. E.
Masiuk, L. Mordasky Markell, N. Blazanin and
A. B. Glick. Center for Molecular Toxicology and
Carcinogenesis, Penn State University, University
Park, PA.
#223 Poster Board Number.....................................405
PHENOBARBITAL-LIKE MODE OF
ACTION FOR LIVER TUMORS IN CD1
MICE AND F344 RATS EXPOSED TO A
NEW DEVELOPMENTAL COMPOUND
(X11422208). ​D. Geter 1 , L. H. Kan 1 , A. Wood 1 , M.
J. LeBaron 1 , B. B. Gollapudi 1 , J. Murray 1 , C. Terry 3 ,
R. Rasoulpour 1 , C. Elcombe 2 , A. Vardy 2 , J. Ross 2
and R. Billington 3 . 1 The Dow Chemical Company,
Midland, MI, 2 CXR BioSciences, Dundee, United
Kingdom and 3 Dow AgroSciences, Abingdon,
Oxfordshire, United Kingdom.
#224 Poster Board Number.....................................406
NON-HUMAN RELEVANCE OF A CAR-
MEDIATED TUMOR FORMATION IN
RATS INDUCED BY THE HERBICIDE
METAZACHLOR. ​C. Wiemann 1 , N. Honarvar 1 ,
M. Göttel 1 , S. Gröters 2 , E. Fabian 2 , B. van
Ravenzwaay 2 and I. Fegert 1 . 1 Regulatory Toxicology
Pesticides, BASF SE, Ludwigshafen, Germany and
2
Experimental Toxicology and Ecology, BASF SE,
Ludwigshafen, Germany. Sponsor: R. Landsiedel.
#225 Poster Board Number.....................................407
LIGAND-DEPENDANT ACTIVATION AND
DEACTIVATION OF NUCLEAR RECEPTOR
SUBFAMILY 4 MEMBERS IN PANCREATIC
CANCER CELLS. ​X. Li 1 and S. Safe 2,3 . 1 College
of Medicine, Texas A&M Health Science Center,
College Station, TX, 2 Veterinary Physiology and
Pharmacology, Texas A&M University, College
Station, TX and 3 Institute of Biosciences &
Technology, Texas A&M Health Science Center,
Houston, TX.
#226 Poster Board Number.....................................408
CANNABINOIDS INDUCE TYROSINE
PHOSPHATASES AND INHIBIT SP
TRANSCRIPTION FACTORS IN COLON
AND PROSTATE CANCER CELLS. ​S.
Sreevalsan 1 , N. Kaminski 3 and S. Safe 1,2 . 1 Veterinary
Physiology and Pharmacology, Texas A&M
University, College Station, TX, 2 Institute of
Biosciences and Technology, Texas A&M Health
Science Center, Houston, TX and 3 Center for
Integrative Toxicology, Michigan State University,
East Lansing, MI.
#227 Poster Board Number.....................................409
HOPS (Humulus lupulus) INHIBITS
ESTROGEN METABOLISM IN NON-
TUMORIGENIC HUMAN BREAST
EPITHELIAL CELLS (MCF-10A CELLS). ​L.
P. Hemachandra, R. P. Chandrasena, B. M. Dietz,
S. Chen, G. F. Pauli, N. R. Farnsworth, G. R.
Thatcher and J. L. Bolton. Medicinal Chemistry &
Pharmacognosy, University of Illinois at Chicago,
Chicago, IL.
#228 Poster Board Number.....................................410
ENDOCRINE TOXICANTS PROMOTE
RESISTANCE TO ANOIKIS AND
INVASIVENESS OF BREAST CANCER
CELLS IN VITRO. ​W. G. Foster and H. L.
Cameron. Obstetrics and Gynecology, McMaster
University, Hamilton, ON, Canada.
#229 Poster Board Number.....................................411
ENVIRONMENTAL CHEMICALS AND
BREAST CANCER: GEOGRAPHIC
ASSOCIATION BETWEEN LIVESTOCK
WASTE, CONTAMINATED SURFACE
WATER, AND BREAST CANCER
INCIDENCE IN THE SAN FRANCISCO BAY
AREA. ​H. Larson 1 , M. Mun 1 , W. Onyenwe 1 and D.
E. Johnson 1,2 . 1 Nutritional Sciences & Toxicology,
University of California, Berkeley, Berkeley, CA
and 2 California Breast Cancer & Chemicals Policy
Project, San Francisco, CA.
#230 Poster Board Number.....................................412
NOVEL P450 REDUCTASE KNOCKOUT
MOUSE MODELS FOR STUDYING
CHEMICAL CARCINOGENESIS IN THE
MAMMARY GLAND. ​Y. Yao 1 , S. Liu 1 , W. Yang 1 ,
B. Moorthy 2 , X. Ding 1 and J. Gu 1 . 1 Wadsworth
Center, New York State Department of Health, and
School of Public Health, State University of New
York at Albany, Albany, NY and 2 Baylor College of
Medicine, Houston, TX.
#231 Poster Board Number.....................................413
IDENTIFYING INHIBITION PATHWAYS
OF MAMMARY CANCER STEM CELLS BY
CHEMICAL GENETICS. ​D. Castro, J. Maurer
and R. Oshima. Tumor Development Program,
Sanford-Burnham Medical Research Institute, La
Jolla, CA.
#232 Poster Board Number.....................................414
SEVERE URINARY BLADDER
CYTOTOXICITY AND REGENERATIVE
HYPERPLASIA WITH DOSE
RESPONSE INDUCED BY ARSENITE
IN ARSENIC (+3 OXIDATION STATE)
METHYLTRANSFERASE KNOCKOUT
MICE. ​M. Yokohira 2,1 , L. L. Arnold 2 , K. L.
Pennington 2 , S. Suzuki 2 , S. Kakiuchi-Kiyota 2 , K.
Herbin-Davis 3 , D. J. Thomas 3 , K. Imaida 1 and S. M.
Cohen 2 . 1 Oncopathology, Kagawa University, Faculty
of Medicine, Kita-gun, Kagawa, Japan, 2 Pathology
and Microbiology, University of Nebraska Medical
Center, Omaha, NE and 3 Pharmacokinetics Branch,
Integrated Systems Toxicology Division, National
Health and Environmental Effects Research
Laboratory, U.S. EPA, Omaha, NE.
134
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