Program - Society of Toxicology

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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # industries, many investigators currently use primary hepatocytes or transformed hepatocyte-derived cell lines in lieu of animal studies. These models have serious limitations including major differences in the expression of xenobiotic metabolizing enzymes compared to the intact liver. There is a clear need for the identification and characterization of biologically-relevant in vitro models that can recapitulate the functions, cell interactions, and responses to chemicals found in vivo. A number of exciting in vitro models of the liver have been recently developed which make them potentially better models for predicting responses in vivo than conventional cultures. We will characterize the use of a number of in vitro models of the liver including 2D and 3D co-cultures containing hepatocytes and other cell types. Our panel of experts have an extensive experience in the characterization and use of these models and will discuss applications of the models including toxicity screening, metabolic activation, mode-of-action determination using toxicogenomics and species extrapolation. This particular topic will be useful to those interested in high-throughput screening, hepatotoxicity, and mode-of-action research. #1311 12:00 LIVERS ON A PLATE: NEXT GENERATION HEPATOCYTE MODELS FOR HIGH- THROUGHPUT SCREENING AND MODE-OF-ACTION PREDICTION. C. Corton 1 , S. Khetani 4 , L. Griffith 3 , D. Applegate 2 and S. D. Hester 1 . 1 Integrated Systems Toxicology Division, U.S. EPA, Durham, NC, 2 RegeneMed, Inc., San Diego, CA, 3 MIT, Cambridge, MA and 4 HepreGen Corporation, Medford, MA. 12:00 INTRODUCTION. Chris Corton 12:05 IN VITRO TOXICOGENOMICS AND CHRONIC TOXICITY ASSESSMENT USING 3D LIVER CO-CULTURE. Dawn Applegate 12:25 PERFUSED MULTIWELL PLATE FOR 3D LIVER TISSUE ENGINEERING. Linda Griffith 12:45 APPLICATIONS OF MICROSCALE ANIMAL AND HUMAN IN VITRO LIVER MODELS IN TOXICOLOGY. Salman Khetani 1:05 HEPATOCYTE MODELS FOR PRIORITIZATION AND MODE-OF-ACTION PREDICTION OF ENVIRONMENTALLY- RELEVANT CHEMICALS. Susan Hester Tuesday Afternoon, March 8 12:15 PM to 1:05 PM Room 201 Distinguished Toxicology Scholar Award Lecture: Cloning and Functional Analysis of the Aryl Hydrocarbon Nuclear Translocator (ARNT) Lecturer: Oliver Hankinson, University of California, Los Angeles, CA. In 1991 we cloned ARNT, which we knew to be required for activity of the Aryl Hydrocarbon Receptor (AHR). We subsequently showed that ARNT is the obligate dimerization partner for AHR. ARNT represented a new class of transcription factor, the basic helix-loop-helix-Per-Arnt- Sim (bHLH-PAS) family. AHR, which was cloned the following year, also proved to be a bHLH-PAS protein. These observations were very surprising, since most investigators expected that AHR and its dimerization partner would be members of the nuclear receptor superfamily. Further studies by our group and others identified functional domains of these proteins, and lead to a broad understanding of their roles in transcriptional activation and chemical carcinogenesis. In 1995, Hypoxia Inducible Factor (HIF) was cloned, and shown to be a dimer of ARNT and another bHLH-PAS protein. Studies by us and others have shown that ARNT is directly involved in tumor growth, angiogenesis, wound healing, diabetes and stroke through its role as a component of HIF. Our recent studies have focused on defining the roles of coactivator and other facilitator proteins in the AHR/ARNT- and HIF-dependent induction of gene transcription. Such proteins may represent nodal points for crosstalk between these pathways and other pathways of gene regulation. Tuesday Afternoon, March 8 12:30 NOON to 2:00 PM Renaissance Congressional A Regional Chapter Student Luncheon: Northeast Regional Chapter Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Medical Devices Chairperson(s): Lori Moilanen, 3M, St. Paul, MN. Displayed: 1:00 PM–4:30 PM Author Attended: 1:00 PM–2:45 PM #1312 Poster Board Number.....................................101 EVALUATION OF THE SENSITIVITY OF ENDPOINTS IN THE ISO 10993-11 SYSTEMIC TOXICITY STANDARD USING POSITIVE CONTROL COMPOUNDS. A. Freeman 1,2 , A. Komiyama 1 , J. Fazio 1,3 , S. Hamilla 1,4 , H. Dinesdurage 1 and R. P. Brown 1 . 1 U.S. FDA, Silver Spring, MD, 2 University of Maryland, College Park, MD, 3 Western New England College, Springfield, MA and 4 University of Connecticut, Storrs, CT. #1313 Poster Board Number.....................................102 RAPID TOXICITY SCREENING OF POLYMERIC MATERIALS USING THE MICROTOX ASSAY. P. Kulkarni, H. Dinesdurage and R. P. Brown. CDRH, U.S. FDA, Silver Spring, MD. 232 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #1314 Poster Board Number.....................................103 USE OF AN IN VITRO SCREEN FOR ASSESSING THE VAGINAL IRRITATION POTENTIAL OF INTIMATE CARE PRODUCTS. P. Clay 1 and N. Belot 2 . 1 SSL International, Manchester, United Kingdom and 2 Straticell, Gembloux, Belgium. Sponsor: D. Kent. #1315 Poster Board Number.....................................104 DETERMINATION OF BISPHENOL-A COMPOUNDS LEACHABLE FROM POLYCARBONATE- AND POLYSULFONE- BASED HEMODIALYZERS. J. Guo, S. Cho and H. D. Luu. Division of Chemistry and Materials Sciences, U.S. FDA, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD. #1316 Poster Board Number.....................................105 HUMAN BIOKINETIC MODEL OF NICKEL RELEASE FROM MEDICAL DEVICES. J. S. Tsuji 1 and K. T. Bogen 2 . 1 Exponent, Bellevue, WA and 2 Exponent, Oakland, CA. #1317 Poster Board Number.....................................106 PRECLINICAL SAFETY ASSESSMENT OF DESMA (CASRN 1101874-33-2) FOR USE IN PROLONGED SURFACE CONTACT DENTAL PRODUCTS. B. D. Bagley 1 , L. H. Moilanen 1 and K. Stefan 2 . 1 Medical Department, 3M, St. Paul, MN and 2 3M ESPE, Seefeld, Germany. #1318 Poster Board Number.....................................107 REPRODUCTIVE TOXICITY EVALUATION OF THE RESIN MONOMER TRIETHYLENE GLYCOL DIMETHACRYLATE (TEGDMA) IN MICE. L. H. Moilanen 1 , J. K. Dahms 3 and A. Hoberman 2 . 1 Medical Department, 3M, St. Paul, MN, 2 Charles River Laboratories, Horsham, PA and 3 3M ESPE, St. Paul, MN. #1319 Poster Board Number.....................................108 PRECLINICAL BIOCOMPATIBILITY ASSESSMENT OF A NEW NANO-FILLED FLOWABLE DENTAL COMPOSITE. E. F. Hope 1 , L. H. Moilanen 1 and A. Bogdan 2 . 1 Medical Department, 3M, St. Paul, MN and 2 3M ESPE, St. Paul, MN. #1320 Poster Board Number.....................................109 POLYPHENOL-ELUTING STENT COATING, A NOVEL APPROACH FOR THE PREVENTION OF RESTENOSIS WITH REDUCED SIDE EFFECTS. J. J. Kleinedler 1 , A. W. Orr 2 , V. Hebert 1 , A. Yurdagul 2 , J. D. Foley 3 and T. R. Dugas 1 . 1 Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, 2 Pathology, Louisiana State University Health Sciences Center, Shreveport, LA and 3 Biomaterials Research, Nanocopoeia, Inc., St. Paul, MN. #1321 Poster Board Number.....................................110 CYTOTOXICITY TESTING STRATEGY OF CONTACT LENS DISINFECTING SOLUTIONS. S. Kostrubsky, K. Bullard and J. Wegrzyn. Vistakon, Division of J&J Vision Care, Jacksonville, FL. Abstract # #1322 Poster Board Number.....................................111 TRANSLATIONAL IMAGING OF AN INJECTABLE POLY-L-LACTIC ACID DERMAL FILLER. N. J. Barlow 1 , D. Wilson 1 , R. Rimsky 1 , L. Wachsmuth 1 , T. Coulthard 2 and X. Ying 1 . 1 Disposition, Safety, and Animal Research, sanofi-aventis U.S., Inc., Bridgewater, NJ and 2 VisualSonics, Inc., Toronto, ON, Canada. #1323 Poster Board Number.....................................112 EVALUATION OF EXTRACTABLES/ LEACHABLES FROM IMPLANTED MEDICAL DEVICES. L. A. Haighton 1,2 , H. Fikree 2 , L. Sarkissian 2 and J. W. Card 2 . 1 Cantox Health Sciences International, Mississauga, ON, Canada and 2 Ashuren Health Sciences, Mississauga, ON, Canada. Tuesday Afternoon, March 8 1:00 PM to 4:30 PM Exhibit Hall Poster Session: Neurotoxicity of Pesticides Chairperson(s): Russell Carr, Mississippi State University, Mississippi State, MS, and Kimberly Jarema, U.S. EPA, Research Triangle Park, NC. Displayed: 1:00 PM–4:30 PM Author Attended: 2:45 PM–4:30 PM #1324 Poster Board Number.....................................114 AGE-RELATED DIFFERENCES IN CHOLINESTERASE (CHE) INHIBITION IN IMMATURE AND ADULT RATS AFTER ACUTE OR REPEATED EXPOSURES TO CHLORPYRIFOS (CPF) OR CPF-OXON (CPFO). M. S. Marty 1 , A. K. Andrus 1 , M. P. Bell 1 , J. K. Passage 1 , A. W. Perala 1 , K. A. Brzak 1 , S. N. Fishman 1 , M. J. Bartels 1 and D. R. Juberg 2 . 1 The Dow Chemical Company, Midland, MI and 2 Dow AgroSciences, Indianapolis, IN. #1325 Poster Board Number.....................................115 REPEATED DEVELOPMENTAL CHLORPYRIFOS EXPOSURE INCREASES ENDOCANNABINOID LEVELS IN THE BRAIN OF JUVENILE RATS. R. L. Carr, A. B. Ward and M. K. Ross. Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS. #1326 Poster Board Number.....................................116 PON1 STATUS MODULATES CEREBELLAR GENE EXPRESSION CHANGES ASSOCIATED WITH DEVELOPMENTAL EXPOSURE TO CHLORPYRIFOS OXON. T. B. Cole 1,2 , R. P. Beyer 2 , T. K. Bammler 2 , S. S. Park 1 , F. M. Farin 2 , L. G. Costa 2 and C. E. Furlong 1 . 1 Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, WA and 2 Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. #1327 Poster Board Number.....................................117 CHLORPYRIFOS AND CHLORPYRIFOS OXON ALTER RYANODINE RECEPTOR FUNCTION. Y. Niknam, A. Ghogha, P. Lein and I. Pessah. Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA. Tuesday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 233
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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Thank You to the following individu
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SOT Celebration Event Floor Plan Ba
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 2011 Awa
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Endowment Awardees for SOT’s 50 t
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Society of Toxicology 2011 SOT Endo
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 Recognit
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Society of Toxicology 2011 RC, SIG,
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Society of Toxicology 2011 Student
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Society of Toxicology 2011 Outreach
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Society of Toxicology 2011 Satellit
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Society of Toxicology 2011 Program
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 Abstract
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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Society of Toxicology 2011 SOT Affi
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Society of Toxicology 2011 Notes up
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