Program - Society of Toxicology

Society of Toxicology 2011
Program Description (Continued)
Abstract #
#995 Poster Board Number.....................................222
EFFECTS OF DIETARY PHENOLICS
AND BOTANICAL EXTRACTS ON
HEPATOTOXICITY-RELATED ENDPOINTS
IN HUMAN AND RAT HEPATOMA CELLS
AND STATISTICAL MODELS FOR
PREDICTION OF HEPATOTOXICITY. ​Y.
Liu 2 , T. Flynn 1 , M. Ferguson 3 , E. Hoagland 1 and L.
Yu 2 . 1 Division of Toxicology, U.S. FDA, Laurel, MD,
2
Nutrition & Food Science, University of Maryland,
College Park, MD and 3 Division of Public Health &
Biostatistics, U.S. FDA, College Park, MD.
#996 Poster Board Number.....................................223
EXPANDED PREVALIDATION FOR THE
ISOLATED RABBIT EYE (IRE) ASSAY. ​F.
Guerriero 1 , C. Seaman 2 , A. Whittingham 3 , A. Else 3 ,
E. Adriaens 4 , R. Guest 3 and M. Olson 1 . 1 H, S&P,
GlaxoSmithKline, Research Triangle Park, NC, 2 H,
S&P, GlaxoSmithKline, Ware, United Kingdom,
3
Harlan Laboratories, Shardlow, United Kingdom
and 4 Adriaens Consulting, Aalter, Belgium.
#997 Poster Board Number.....................................224
CYTOTOXICITY AND GENOTOXICITY OF
PHENAZINE IN HUMAN CELL LINES. ​C.
F. McGuigan 1 , S. Gabos 2 and X. Li 1 . 1 Division of
Analytical & Environmental Toxicology, University
of Alberta, Edmonton, AB, Canada and 2 Alberta
Health and Wellness, Edmonton, AB, Canada.
Sponsor: R. Bull.
#998 Poster Board Number.....................................225
IN VITRO EXPOSURE OF
ORGANOTYPICAL 3D EPITHELIAL
TISSUES TO CIGARETTE SMOKE AS A
POTENTIAL ALTERNATIVE TO RODENT
INHALATION STUDIES. ​D. Weisensee, B.
Kurkowsky, M. Hebestreit and S. Wagner. Philip
Morris Research and Development, Philip Morris
Research Laboratories GmbH, Cologne, Germany.
Sponsor: E. Roemer.
#999 Poster Board Number.....................................226
EVALUATION OF MALE RAT ENDOCRINE
TOXICITY USING THE IN VITRO RAT
TESTICULAR CELL LINE R2C. ​R.
Kuk 1 , P. S. Giffen 2 , S. B. Laffan 1 and D. J.
Stanislaus 1 . 1 Reproductive Toxicology, Safety
Assessment, GlaxoSmithKline, King of Prussia,
PA and 2 SA Pathology, Preclinical Development,
GlaxoSmithKline, Ware, Hertfordshire, United
Kingdom.
#1000 Poster Board Number.....................................227
THE DEVELOPMENT OF AN IN VITRO
ASSAY TO PREDICT SKIN SENSITIZATION
BASED ON ROS PRODUCTION. ​K. Saito,
M. Miyazawa, Y. Nukada, H. Sakaguchi and N.
Nishiyama. Kao Corporation, Tochigi, Japan.
Sponsor: J. Avalos.
#1001 Poster Board Number.....................................228
A TIERED APPROACH COMBINING FOUR
IN VITRO ASSAYS FOR PREDICTING EYE
IRRITATION POTENTIAL OF CHEMICALS. ​
K. Hayashi 1 , T. Abo 1 , K. Ooshima 2 , T. Hayashi 2 , T.
Komano 2 , R. Fautz 3 , T. Simion 4 and H. Sakaguchi 1 .
1
Kao Corporation, Tochigi, Japan, 2 Kanebo
Cosmetics Inc., Kanagawa, Japan, 3 Kao Professional
Salon Services GmbH, Darmstadt, Germany and
4
Kao Brands Company, Cincinnati, OH.
Abstract #
#1002 Poster Board Number.....................................229
TOWARDS ANIMAL-FREE TESTING
FOR SKIN SENSITIZATION: IN-HOUSE
VALIDATION OF FOUR METHODS: MUSST,
H-CLAT, KERATINOSENS, AND DPRA. ​C.
Bauch 1,2 , T. Eltze 1 , E. Fabian 1 , S. N. Kolle 1 , C.
Pachel 1,3 , T. R. Hernandez 1 , B. Wiench 1,4 , C. J.
Wruck 2 , R. Landsiedel 1 and B. van Ravenzwaay 1 .
1
Experimental Toxicology and Ecology, BASF
SE, Ludwigshafen, Germany, 2 Department of
Anatomy and Cell Biology, RWTH Aachen
University, Aachen, Germany, 3 Technical University
Kaiserslautern, Kaiserslautern, Germany and 4 Faculty
of Chemistry, Pharmaceutics, and Geosciences,
Johannes Gutenberg University Mainz, Mainz,
Germany. Sponsor: A. Van Cott.
#1003 Poster Board Number.....................................230
ASSESSMENT OF AIRWAY GENOTOXICITY
POTENTIAL USING THE EPIAIRWAY IN
VITRO HUMAN AIRWAY MODEL AND
THE COMET ASSAY. ​A. Armento, J. DeLuca,
Y. Kaluzhny, H. Kandarova, M. Klausner and P. J.
Hayden. MatTek Corp., Ashland, MA.
#1004 Poster Board Number.....................................231
APPLICATION OF PRECISION-CUT
LIVER SLICES FOR THE INVESTIGATION
OF XENOBIOTIC-INDUCED CELL
PROLIFERATION. ​E. Fabian 1 , F. Schuck 2,1 , C.
Jaeckh 1 , S. Groetters 1 , B. van Ravenzwaay 1 and R.
Landsiedel 1 . 1 Expermental Toxicology and Ecology,
BASF SE, Ludwigshafen, Germany and 2 Johannes
Gutenberg-University, Mainz, Germany.
#1005 Poster Board Number.....................................232
EVALUATION OF XENOBOTIC
METABOLISM IN HUMAN
RECONSTRUCTED SKIN MODELS FOR
GENOTOXICITY TESTING. ​C. Jaeckh 1 ,
V. Blatz 1 , E. Fabian 1 , K. Reisinger 2 , B. van
Ravenzwaay 1 , S. Trappe 3 and R. Landsiedel 1 .
1
BASF SE, Experimental Toxicology and Ecology,
Ludwigshafen, Germany, 2 Henkel AG and Co.,
KGaA, Duesseldorf, Germany and 3 Bundesinstitut
for Risikobewertung, Berlin, Germany.
#1006 Poster Board Number.....................................233
CUTANEOUS METABOLISM. ​J. Eilstein, G.
Léreaux, J. Meunier, J. Leclaire and D. Duché. Life
Sciences Research-Safety Research Department,
L’Oréal Advance Research, Aulnay-sous-Bois,
France. Sponsor: H. Toutain.
#1007 Poster Board Number.....................................234
ASSESSMENT OF COMBINATIONS
OF ANTIANDROGENIC COMPOUNDS
VINCLOZOLIN AND FLUTAMIDE IN A
YEAST BASED REPORTER ASSAY. ​S.
Kolle 1 , G. Krenrich 2 , B. van Ravenzwaay 1 and R.
Landsiedel 1 . 1 BASF SE, Experimental Toxicology
and Ecology, Ludwigshafen, Germany and 2 BASF
SE, GVC/S Scientific Computing, Ludwigshafen,
Germany. Sponsor: A. Doi.
#1008 Poster Board Number.....................................235
SCREENING FOR ENDOCRINE
DISRUPTORS IN PRODUCT
DEVELOPMENT: TIERED TESTING USING
IN VITRO AND IN VIVO ASSAYS. ​B. van
Ravenzwaay, S. Kolle, R. Buesen, H. Kamp and R.
Landsiedel. BASF SE, Experimental Toxicology and
Ecology, Ludwigshafen, Germany. Sponsor: A. Doi.
Tuesday
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