Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
Monday Morning, March 7
9:15 AM to 12:00 NOON
Room 145
Integration of Toxicological and Epidemiological Evidence
to Understand Human Risk
Workshop Session: New Approaches for Integrating
Toxicological and Epidemiological Data to Better Inform Risk
Assessment
Chairperson(s): Daland Juberg, Dow AgroSciences, Indianapolis, IN,
and Anna Lowit, U.S. EPA, Washington, D.C.
Sponsor:
Regulatory and Safety Evaluation Specialty Section
Endorsed by:
Occupational and Public Health Specialty Section
Risk Assessment Specialty Section
There is increasing scientific and regulatory interest in determining how
to better integrate animal toxicological data and epidemiological evidence
into the risk assessment process. This need stems from the growing body
of literature on environmental epidemiology and the frequent disparity
observed in human and animal data relative to reported outcomes. This
workshop will identify the expectations and limitations that are inherent in
animal and epidemiological studies and how existing and emerging tools,
technologies, and study designs may be better utilized for scientificallydefensible
and informed risk assessments. We will review the challenges
that exist with both data types (i.e., animal and epidemiologic) and identify
the types of tools and data that would allow improved integration of
epidemiology and experimental toxicology studies through exploration of a
common marker of dosimetry that would facilitate cross-comparison of data
sets. A perspective on study design and dosing regimes used in regulatory
studies will be presented as well as review of advancements that improve
our ability to compare animal data with known or modeled human exposures.
Epidemiology study design and the opportunities and limitations that
exist for simultaneously characterizing exposures and risks in humans will
be reviewed. Insight on some of the new tools and technologies that enable
a more refined analysis of biological plausibility and mode of action, both
critical when assessing animal and human data for use in risk assessment,
will be provided. Finally, advancements in exposure science within the
context of some U.S. EPA projects and research aimed at utilizing multiple
sources of information (i.e., exposure data, internal biomarkers, and PBPK
modeling) for improvements in our knowledge on chemical exposures to
humans will be discussed.
#47 9:15 NEW APPROACHES FOR
INTEGRATING TOXICOLOGICAL AND
EPIDEMIOLOGICAL DATA TO BETTER
INFORM RISK ASSESSMENT. ​D. R. Juberg.
Dow AgroSciences, Indianapolis, IN.
9:15 INTRODUCTION. ​Daland Juberg
#48 9:20 USING EPIDEMIOLOGY IN HUMAN
HEALTH RISK ASSESSMENT: RECENT
ADVANCES. ​A. Lowit. Office of Pesticide
Programs, U.S. EPA, Washington, D.C.
#49 9:46 NEW APPROACHES TO TOXICOLOGY
STUDY DESIGN: LINKING TESTING DOSE
RESPONSE AND DOSIMETRY TO HUMAN
EXPOSURE AND HEALTH OUTCOMES. ​J.
Bus. The Dow Chemical Company, Midland, MI.
#50 10:12 THE ROLE OF EPIDEMIOLOGIC
RESEARCH IN RISK ASSESSMENT: SOME
CHALLENGES AND OPPORTUNITIES. ​S.
A. Harris 1,2,3 . 1 Population Studies and Surveillance,
Cancer Care Ontario, Toronto, ON, Canada,
2
Occupational Cancer Research Centre, Toronto,
ON, Canada and 3 Dalla Lana School of Public
Health, Divisions of Epidemiology and Occupational
and Environmental Health, University of Toronto,
Toronto, ON, Canada. Sponsor: D. Juberg.
#51 10:38 NEW TOOLS AND APPROACHES TO LINK
TOXICOLOGICAL MODELS TO HUMAN
HEALTH EFFECTS. ​R. S. Thomas. The Hamner
Institutes for Health Sciences, Research Triangle
Park, NC.
#52 11:04 THE ITERATIVE ROLE OF EXPOSURE
SCIENCE IN RISK ASSESSMENT. ​R. Tornero-
Velez. U.S. EPA, Research Triangle Park, NC.
Sponsor: D. Juberg.
11:30 PANEL DISCUSSION/Q&A.
Monday Morning, March 7
9:15 AM to 12:00 NOON
Room 206
Platform Session: Nanotoxicology—Carbon Nanotubes and
Carbon Nanoparticles
Chairperson(s): Galya Orr, Pacific Northwest National Laboratory,
Richland, WA, and Harald Krug, EMPA—Materials and Technology, St.
Gallen, Switzerland.
#53 9:15 ACUTE PULMONARY RESPONSES TO
MWCNT INHALATION. ​M. G. Wolfarth 1 , W.
McKinney 1 , B. T. Chen 1 , V. Castranova 1,2 and D. W.
Porter 1,2 . 1 HELD/PPRB, NIOSH, Morgantown, WV
and 2 Physiology and Pharmacology, West Virginia
University, Morgantown, WV.
#54 9:34 BIODEGRADATION OF CARBON
NANOTUBES BY EOSINOPHIL
PEROXIDASE. ​A. A. Kapralov 1 , N. Yanamala 1 , W.
H. Feng 1 , B. Fadeel 2 , A. Star 3 , A. A. Shvedova 4 and V.
E. Kagan 1 . 1 Center for Free Radical and Antioxidant
Health, EOH, University of Pittsburgh, Pittsburgh,
PA, 2 Division of Biochemical Toxicology, Karolinska
Institutet, Stockholm, Sweden, 3 Department of
Chemistry, University of Pittsburgh, Pittsburgh, PA
and 4 Pathology and Physiology Research Branch,
NIOSH, Morgantown, WV.
#55 9:53 LONG, FIBROUS CARBON NANOTUBES
ACTIVATE THE NLRP3 INFLAMMASOME
IN HUMAN MACROPHAGES AND INDUCE
NEUTROPHILIA IN MICE LUNGS AFTER
INTRATRACHEAL ADMINISTRATION. ​J.
Palomäki, E. M. Rossi, K. Savolainen, S. Matikainen
and H. Alenius. Finnish Institute of Occupational
Health, Helsinki, Finland.
#56 10:12 PULMONARY FIBROTIC RESPONSE TO
SUB-CHRONIC MULTI-WALLED CARBON
NANOTUBE EXPOSURE. ​R. R. Mercer, A.
F. Hubbs, J. F. Scabilloni, L. Wang, L. A. Battelli,
V. Castranova and D. W. Porter. PPRB, NIOSH,
Morgantown, WV.
120
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