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50 th Anniversary Annual Meeting and ToxExpo Program Description (Continued) MONday Abstract # Abstract # #194 Poster Board Number.....................................336 TIME-COURSE OF IMPAIRED CORONARY ARTERIOLAR ENDOTHELIUM- DEPENDENT DILATION AFTER MULTI-WALLED CARBON NANOTUBE INHALATION. P. G. Stapleton 1,3 , V. C. Minarchick 1,3 , A. Cumpston 2 , W. McKinney 2 , B. T. Chen 2 , D. Frazer 2 , V. Castranova 2 and T. R. Nurkiewicz 1,3 . 1 Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, WV, 2 Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV and 3 Physiology and Pharmacology, West Virginia University, Morgantown, WV. #195 Poster Board Number.....................................337 PROLONGATION OF QT INTERVALS BY MOXIFLOXACIN TREATMENT IN 2 AND 8 WEEK OLD JUVENILE BEAGLE DOGS. M. Peschar 1 , N. Lourens 1 , K. Scase 1 , A. Zmarowski 1 , M. De Raaf 1 , E. Padgett 2 , B. Van Rozendaal 1 and H. Emmen 1 . 1 Toxicology, NOTOX B.V., DD‘s- Hertogenbosch, Netherlands and 2 Toxicology, WIL Research Laboratories LLC, Ashland, OH. #196 Poster Board Number.....................................338 REGULATION OF CARDIAC CARDIOTROPHIN-1 GENE EXPRESSION BY VALSARTAN AND SPIRONOLACTONE IN RAT, A POSSIBLE MECHANISM OF CARDIOPROTECTION. H. A. Al-Mazroua, N. M. Al-Rasheed and H. M. Korashy. Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Sponsor: A. El-Kadi. #197 Poster Board Number.....................................339 TCDD MISREGULATES CELL MIGRATION AND THE EXTRACELLULAR MATRIX IN THE REGENERATING ZEBRAFISH HEART. P. J. Hofsteen 1 , M. Kim 1 , D. Nesbit 1 , V. Mehta 2 , R. E. Peterson 1,2 and W. Heideman 1,2 . 1 School of Pharmacy, University of Wisconsin Madison, Madison, WI and 2 Molecular and Environmental Toxicology, University of Wisconsin, Madison, WI. #198 Poster Board Number.....................................340 TCDD EXPOSURE ALTERS THE GENE EXPRESSION RESPONSE TO HEART REGENERATION IN ADULT ZEBRAFISH (DANIO RERIO). M. Kim, R. E. Peterson and W. Heideman. Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin, Madison, WI. #199 Poster Board Number.....................................341 2, 3, 7, 8-TETRACHLORODIBENZO-P- DIOXIN INDUCES PRO-HYPERTENSIVE AND -ADIPOGENIC GENE EXPRESSION IN MESENTERIC ARTERIOLES PRIOR TO THE ONSET OF HYPERTENSION. M. K. Walker, J. A. Scott and J. R. Boberg. Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM. #200 Poster Board Number.....................................342 GLUCOCORTICOID INDUCED LEUCINE ZIPPER PREVENTS APOPTOSIS BY CARDIAC TOXINS. D. C. Aguilar, J. Strom, B. Xu and Q. Chen. Pharmacology, University of Arizona, Tucson, AZ. #201 Poster Board Number.....................................343 IS STRUCTURAL DAMAGE TO THE HEART ASSOCIATED WITH FUNCTIONAL CHANGES? L. Ewart, A. Hargreaves, T. Hammond, P. Lainee, J. Harleman and J. Valentin. AstraZeneca, Macclesfield, United Kingdom. #202 Poster Board Number.....................................344 USE OF NATRIURETIC PEPTIDES TO DETECT COMPOUND RELATED CHANGES IN BLOOD PRESSURE IN RODENTS. S. K. Engle, L. Huber, D. Sall, M. Uhlik and D. E. Watson. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN. #203 Poster Board Number.....................................345 THE C-TERMINUS OF THE CARDIAC ELECTRONEUTRAL SODIUM BICARBONATE COTRANSPORTER HHNBCN1 IS CYTOTOXIC. N. Magilnick, N. Abuladze, P. Ge, I. Atanasov and A. Pushkin. D. Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA. Sponsor: W. Dekant. #204 Poster Board Number.....................................346 USING SOD2 HETEROZYGOUS MOUSE MODEL TO STUDY THE MECHANISM OF DOXORUBICIN INDUCED CARDIAC TOXICITY. W. Hu, W. Collette, L. Liu, M. Hemkens, J. Heyen, S. Aquirre, L. Marroquin, B. Jessen and V. Torti. DSRD, Pfizer, San Diego, CA. #205 Poster Board Number.....................................347 INDUCTION OF CARDIOTOXICITY BY PERFLUOROOCTANOIC ACID IN AN AVIAN MODEL. Q. Jiang and J. DeWitt. East Carolina University, Greenville, NC. #206 Poster Board Number.....................................348 CHRONIC OVEREXPRESSION OF RECEPTOR TYROSINE KINASE ERBB2 INDUCES CELLULAR OXIDATIVE STRESS IN THE HEARTS OF MICE. F. Belmonte 1 , Y. Xu 1 , S. Polina 1 , C. Steenbergen 2 , S. Das 2 , X. Guo 1 , S. Pin 1 , D. Bedja 1 and K. Gabrielson 1 . 1 Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD and 2 Cardiovascular Pathology, Johns Hopkins University, Baltimore, MD. #207 Poster Board Number.....................................349 RECOVERY OF CYTOCHROME C OXIDASE ACTIVITY IS REQUIRED FOR DIETARY COPPER SUPPLEMENTATION- INDUCED REGRESSION OF CARDIAC HYPERTROPHY IN MICE. L. Zhan 1 , L. Hussain 1 , Y. Yao 1 , W. Feng 2 , K. Bourcy 1 , J. Eaton 2 , W. Johnson 3 , C. Moraes 4 and Y. Kang 1 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY, 2 Medicine, University of Louisville, Louisville, KY, 3 Human Nutrition Research Center, U.S. Department of Agriculture, Grand Forks, ND and 4 Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL. 132 Education-Career Development Sessions Exhibitor Hosted Sessions Featured Sessions Historical Highlights Informational Sessions Platform Sessions
Society of Toxicology 2011 Program Description (Continued) Abstract # #208 Poster Board Number.....................................350 THE INVOLVEMENT OF VIMENTIN IN THE CU INDUCED REGRESSION OF HYPERTROPHY IN HUMAN CARDIAC MYOCYTES. K. S. Bourcy 1 , W. Feng 2 and Y. Kang 1 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY and 2 Medicine, University of Louisville, Louisville, KY. #209 Poster Board Number.....................................351 DIRECT EFFECTS OF NRTIS ON MITOCHONDRIA CONTRIBUTE TO ENDOTHELIAL DYSFUNCTION. M. C. Glover, S. Xue, V. Y. Hebert, J. H. Zavecz and T. R. Hebert. Pharmacology, Toxicology, and Neuroscience, Lousiana State University Health Sciences Center, Shreveport, LA. #210 Poster Board Number.....................................352 ANG II INDUCED PKC/NOX ACTIVATION- ASSOCIATED NITROSATIVE DAMAGE PLAYS A CRITICAL ROLE IN CHRONIC ALCOHOL-CAUSED CARDIAC CELL DEATH AND CARDIOMYOPATHY. Y. Tan, Z. Zhou and L. Cai. Pediatrics/Medicine, University of Louisville, Louisville, KY. #211 Poster Board Number.....................................353 ASSESSMENT OF THE VARIATION IN TROPONIN I LEVELS IN THE DOG DURING THE PERIOD PRIOR TO TOXICOLOGICAL STUDY DOSING. C. J. Betts, T. Child, S. J. Bickerton, M. Moores, N. Derbyshire, H. T. Thomas, M. C. Jacobsen and S. Robinson. Safety Assessment, AstraZeneca, Macclesfield, Cheshire, United Kingdom. #212 Poster Board Number.....................................354 EGCG DECREASES POLYCHLORINATED BIPHENYL-INDUCED EXPRESSION OF CYP1A1 AND ENDOTHELIAL INFLAMMATORY PARAMETERS VIA INDUCTION OF ANTIOXIDANT ELEMENTS. B. Hennig 1 , S. Han 1 and M. Toborek 2 . 1 Animal and Food Sciences, University of Kentucky, Lexington, KY and 2 Department of Neurosurgery, University of Kentucky, Lexington, KY. #213 Poster Board Number.....................................355 QUANTITATIVE PROTEOMICS REVEALS RAPID CHANGES IN NA+/K+ ATPASE AND NCX1 LEVELS IN ADULT ZEBRAFISH HEART FOLLOWING TCDD EXPOSURE. K. Lanham 1 , J. Zhang 2 , R. Peterson 2 , W. Heideman 2 and L. Li 2 . 1 Biomolecular Chemistry, University of Wisconsin Madison, Madison, WI and 2 School of Pharmacy, University of Wisconsin Madison, Madison, WI. #214 Poster Board Number.....................................356 HSP90-BETA OVEREXPRESSION IN THE MOUSE HEART INDUCES HEART FAILURE. Y. Xu 1 , D. Bedja 1 , X. Guo 1 , M. Mei 1 , P. Sysa Shah 1 , S. Das 2 , C. Steenbergen 2 and K. Gabrielson 1 . 1 Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD and 2 Cardiac Pathology, Johns Hopkins University, Baltimore, MD. Abstract # #215 Poster Board Number.....................................357 HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES FOR ASSESSING DRUG-INDUCED CARDIAC ARRHYTHMIAS. B. Anson 1 , J. Ma 1 , L. Guo 2 , S. Fiene 1 , R. Adams 2 , T. Weiser 3 , T. Singer 3 and K. Kolaja 2 . 1 Cellular Dynamics International, Madison, WI, 2 Nonclinical Safety, F. Hoffman-La Roche, Nutley, NJ and 3 Pharmacology Research and Early Development, F. Hoffman-La Roche AG, Basel, Switzerland. #216 Poster Board Number.....................................358 ISIS 416858, AN ANTISENSE INHIBITOR OF FACTOR XI, IS WELL TOLERATED AND PRODUCES NO RISK OF BLEEDING IN THE CYNOMOLGUS MONKEY FOR UP TO 13 WEEKS OF TREATMENT. H. S. Younis 1 , J. Crosby 2 and S. P. Henry 1 . 1 Preclinical Development, ISIS Pharmaceuticals, Carlsbad, CA and 2 Drug Discovery, ISIS Pharmaceuticals, Carlsbad, CA. #217 Poster Board Number.....................................359 BENZO[A]PYRENE AUGMENTS INFLAMMATORY AND PROTEOLYTIC CHANGES IN MOUSE MODEL OF ABDOMINAL AORTIC ANEURYSM. P. A. Prins 1 , P. R. Perati 1 , A. Ramesh 2 , Z. Guo 2 and U. K. Sampson 1 . 1 Cardiovascular Medicine, Vanderbilt University, Nashville, TN and 2 Meharry Medical College, Nashville, TN. #218 Poster Board Number.....................................360 ARYL HYDROCARBON RECEPTOR AGONIST - PCB 77 - INCREASES THE INCIDENCE AND SEVERITY OF ABDOMINAL AORTIC ANEURYSM. V. Arsenescu, R. Arsenescu and L. Cassis. GCNS, University of Kentucky, Lexington, KY. Sponsor: H. Swanson. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall Poster Session: Carcinogenesis I Chairperson(s): John Wisler, Amgen Inc., Thousand Oaks, CA. Displayed: 9:30 AM–12:30 PM Author Attended: 9:30 AM–11:00 AM #219 Poster Board Number.....................................401 NNK, A TOBACCO-SPECIFIC CARCINOGEN, INHIBITS THE EXPRESSION OF LYSYL OXIDASE: A TUMOR SUPPRESSOR GENE. Y. Zhao, S. Gao, J. Zhou, P. Toselli and W. Li. Biochemistry, Boston University School of Medicine, Boston, MA. #220 Poster Board Number.....................................402 GT-094, A NO-NSAID, INHIBITS COLON CANCER CELL GROWTH BY ACTIVATION OF A REACTIVE OXYGEN SPECIES (ROS)- MICRORNA-27A:ZBTB10-SPECIFICITY PROTEIN (SP) PATHWAY. S. Pathi 1 and S. Safe 1,2 . 1 Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX and 2 Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX. MONday Poster Sessions Regional Interest Session Roundtable Sessions Symposium Sessions Thematic Sessions Workshop Sessions 133
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50 th Anniversary Annual Meeting &
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Scientific Program Overview A page
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9:00 AM-12:30 PM POSTER SESSionS
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March 6-10, 2011 Walter E. Washingt
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Celebration Activities Historical H
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of the Society Regional Chapter Yea
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SOT Presidents 1961-2011 1966 1967
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The SOT Council Thanks and Recogniz
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of the Past 50 Years 2003 Michael D
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50 th Anniversary Annual Meeting an
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Toxicological Sciences The Official
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Society of Toxicology 2011 Walter E
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2011 SOT 50 th Anniversary Featured
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Society of Toxicology 2011 Washingt
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Society of Toxicology 2011 ToxExpo
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Society of Toxicology 2011 Exhibito
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Creating a Safer and Healthier Worl
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Society of Toxicology 2011 General
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SOT Job Bank YOUR RECRUITMENT AND E
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Society of Toxicology 2011 SOT 2011
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Society of Toxicology 2011 Author I
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Society of Toxicology 2011 2010-201
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Society of Toxicology 2011 Elected
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Society of Toxicology 2011 Endowmen
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