Program - Society of Toxicology

50 th Anniversary Annual Meeting and ToxExpo
Program Description (Continued)
MONday
Abstract # Abstract #
#706 Poster Board Number.....................................708
DEVELOPMENT OF HUMAN GESTATION
AND LACTATION PBPK MODELS FOR
PERFLUOROOCTANOATE (PFOA) AND
PERFLUOROOCTANESULFONATE (PFOS). ​
A. E. Loccisano 1 , M. E. Andersen 1 , J. Butenhoff 2 and
H. J. Clewell 1 . 1 The Hamner Institutes for Health
Sciences, Research Triangle Park, NC and 2 3M
Corporation, St. Paul, MN.
#707 Poster Board Number.....................................709
LIFE-STAGE PBPK MODELS FOR
MULTIPLE ROUTES OF ETHANOL
EXPOSURE IN THE RAT. ​S. A. Martin 1,7 , J. L.
Campbell 2 , K. Choi 2 , H. J. Clewell 2 , H. El-Masri 3,7 ,
W. R. LeFew 3,7 , T. E. Beasley 1,7 , W. M. Oshiro 1,7 ,
L. L. Degn 1,7 , P. A. Evansky 4,7 , A. Ledbetter 4,7 , J.
Ford 5,7 , D. W. Herr 1,7 , W. K. Boyes 1,7 , P. J. Bushnell 1,7
and E. D. McLanahan 6,7 . 1 NB/TAD/NHEERL/ORD,
Research Triangle Park, NC, 2 The Hamner Institutes
for Health Sciences, Research Triangle Park, NC,
3
SBB/ISTD/NHEERL/ORD, Research Triangle
Park, NC, 4 ITFB/EPHD/NHEERL/ORD, Research
Triangle Park, NC, 5 ACRC/RCU/NHEERL/ORD,
Research Triangle Park, NC, 6 NCEA/ORD, Research
Triangle Park, NC and 7 U.S. EPA, Research Triangle
Park, NC.
#708 Poster Board Number.....................................710
ANALYSIS OF BISPHENOL A KINETICS
AND METABOLISM IN NEONATAL AND
ADULT MONKEYS AND RATS USING A
PBPK MODEL. ​J. Fisher, N. C. Twaddle, M.
Vanlandingham and D. R. Doerge. Biochemical
Toxicology Division, U.S. FDA NCTR, Jefferson,
AR.
#709 Poster Board Number.....................................711
PHYSIOLOGICALLY BASED
PHARMACOKINETIC MODELING
(PBPK) AS A TOOL TO PREDICT 2, 3, 7,
8-TETRACHLORODIBENZO-P-DIOXIN
(TCDD) PHARMACOKINETICS (PK)
DURING GESTATION AND LACTATION. ​C.
Emond 1,2 , M. J. Devito 3 , M. Warner 4 , B. Eskenazi 4 ,
P. Mocarelli 5 and L. S. Birnbaum 6 . 1 BioSimulation
Consulting Inc., Newark, DE, 2 University of
Montréal, Montréal, QC, Canada, 3 NIEHS & NTP,
Research Triangle Park, NC, 4 School of Public
Health, University of California, Berkeley, CA,
5
Department of Laboratory Medicine, University
of Milano-Bicocca, School of Medicine, Hospital
of Desio, Desio, Desio-Milano, Italy and 6 NCI &
NIEHS, Research Triangle Park, NC.
#710 Poster Board Number.....................................712
DEVELOPMENT OF PHYSIOLOGICALLY
BASED PHARMACOKINETIC (PBPK)
MODEL TO PREDICT TULATHROMYCIN
DISTRIBUTION IN GOATS. ​T. L. Leavens 1 ,
L. A. Tell 2 , K. A. Clothier 2 , R. W. Griffith 3 , R. E.
Baynes 1 and J. E. Riviere 1 . 1 Center for Chemical
Toxicology Research and Pharmacokinetics, North
Carolina State University, Raleigh, NC, 2 Department
of Medicine and Epidemiology, University of
California Davis, CA and 3 Department of Veterinary
Microbiology and Preventive Medicine, Iowa State
University, Ames, IA.
#711 Poster Board Number.....................................713
APPLICATION OF A MULTIROUTE
HUMAN PBPK MODEL FOR
BROMODICHLOROMETHANE (BDCM). ​
E. M. Kenyon 1 , T. L. Leavens 2 , C. Eklund 1 and R.
A. Pegram 1 . 1 ORD/NHEERL/ISTD, U.S. EPA,
Durham, NC and 2 Center for Chemical Toxicology
Research and Pharmacokinetics, North Carolina State
University, Raleigh, NC.
#712 Poster Board Number.....................................714
A PHYSIOLOGICALLY BASED
PHARMACOKINETIC (PBPK) TOOL
KIT TO EVALUATE EXPOSURES TO
ENVIRONMENTAL POLLUTANTS. ​M.
Mumtaz 1 , P. Ruiz 1 , M. Ray 2 , J. Fisher 3 and S. Hays 4 .
1
Department of Toxicology and Environmental
Medicine, ATSDR, Atlanta, GA, 2 University of
South Carolina, Columbia, SC, 3 U.S. FDA, National
Center for Toxicological Research, Jefferson, AR and
4
Summit Toxicology Inc., Lyons, CO.
#713 Poster Board Number.....................................715
DERIVATION OF CHEMICAL-SPECIFIC
ADJUSTMENT FACTORS FOR HUMAN
VARIABILITY IN TOXICOKINETICS OF
ACETONE. ​G. Johanson and A. Mörk. Work
Environment Toxicology, Karolinska Institute,
Stockholm, Sweden.
#714 Poster Board Number.....................................716
PRIORITIZING TOXCAST CHEMICALS
ACROSS MULTIPLE SECTORS OF
TOXICITY USING TOXPI. ​D. Reif, M. Martin,
M. Holly, S. Gangwal, A. Wang, R. Judson, P.
Volarath, R. Kavlock and D. Dix. National Center for
Computational Toxicology, U.S. EPA, Durham, NC.
#715 Poster Board Number.....................................717
INTEGRATION OF HIGH-THROUGHPUT
SCREENING DATA WITH DOSIMETRY AND
HUMAN EXPOSURE IN THE TOXICITY
ASSESSMENT OF ENVIRONMENTAL
CHEMICALS. ​B. A. Wetmore 1 , J. F. Wambaugh 2 ,
D. M. Rotroff 2,3 , H. J. Clewell 1 , M. E. Andersen 1 ,
S. Ferguson 4 , D. J. Dix 2 and R. S. Thomas 1 .
1
The Hamner Institutes for Health Sciences,
Research Triangle Park, NC, 2 National Center for
Computational Toxicology, U.S. EPA, Research
Triangle Park, NC, 3 Department of Environmental
Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC and 4 Life
Technologies, Inc., Durham, NC.
#716 Poster Board Number.....................................718
A BIOLOGICALLY INFORMED
FRAMEWORK FOR THE ANALYSIS OF
THE PPAR SIGNALING PATHWAY USING A
BAYESIAN NETWORK. ​A. Beam 1,2 , W. John 1 , R.
Setzer 1 , K. Houck 1 , S. Imran 1 , D. Dix 1 and R. Judson 1 .
1
U.S. EPA/ORD/NCCT, Research Triangle Park,
NC and 2 Statistics, North Carolina State University,
Raleigh, NC.
#717 Poster Board Number.....................................719
MODELING REPRODUCTIVE TOXICITY
FOR CHEMICAL PRIORITIZATION INTO
AN INTEGRATED TESTING STRATEGY. ​
M. T. Martin, T. Knudsen, K. Houck, R. Judson, R.
Kavlock and D. Dix. NCCT, U.S. EPA, Research
Triangle Park, NC.
176
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